A5072137820- Diabetes Treatment and Management
- Pharmacology and Obesity Treatment
- Diabetes Management and Research
- Nerve injury and regeneration
- Medication Adherence and Compliance
- Mesenchymal stem cell research
- Diabetes and associated disorders
- Diabetes Management and Education
- Patient Satisfaction in Healthcare
- Pharmaceutical Practices and Patient Outcomes
- Mobile Health and mHealth Applications
- Pharmacy and Medical Practices
- Healthcare Policy and Management
- Wound Healing and Treatments
- Pancreatic function and diabetes
- Adenosine and Purinergic Signaling
- Chronic Kidney Disease and Diabetes
- Healthcare Operations and Scheduling Optimization
- Adrenal Hormones and Disorders
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Nutrition, Health and Food Behavior
- Blood Pressure and Hypertension Studies
- Advanced Glycation End Products research
- Obesity, Physical Activity, Diet
Toyota Central Research and Development Laboratories (Japan)
2018-2020
Japanese Society for Dialysis Therapy
2017
Aichi Gakuin University
2015
Nagoya University
2008-2014
Ichinomiya Municipal City Hospital
2009
OBJECTIVE—Mesenchymal stem cells (MSCs) have been reported to secrete various cytokines that exhibit angiogenic and neurosupportive effects. This study was conducted investigate the effects of MSC transplantation on diabetic polyneuropathy (DPN) in rats. RESEARCH DESIGN AND METHODS—MSCs were isolated from bone marrow adult rats transplanted into hind limb skeletal muscles with an 8-week duration streptozotocin (STZ)-induced diabetes or age-matched normal by unilateral intramuscular...
Abstract Introduction Dental pulp stem cells (DPSCs) are mesenchymal located in dental and thought to be a potential source for cell therapy since DPSCs can easily obtained from teeth extracted orthodontic reasons. Obtained cryopreserved until necessary thawed expanded when needed. The aim of this study is evaluate the therapeutic DPSC transplantation diabetic polyneuropathy. Methods isolated incisors Sprague–Dawley rats were partly frozen −80 °C freezer 6 months. Cultured transplanted into...
Abstract Aim Periodontal disease is highly prevalent and severe in diabetic patients, considered one of the complications. To elucidate how periodontitis progresses diabetes, we examined an animal model rats. Materials Methods Two weeks after induction diabetes by streptozotocin, surgical nylon thread was ligated around cervical portion unilateral maxillary second molar to induce periodontitis. Periodontitis evaluated 2 ligation gingival blood flow, m RNA expressions, Western blot analysis,...
Objective and Methods An SGLT2 inhibitor (ipragliflozin, dapagliflozin, luseogliflozin, tofogliflozin, or canagliflozin) was administered to 132 outpatients with type 2 diabetes mellitus without other antidiabetic drugs for 6 months evaluate its efficacy, the incidence of adverse events, influence on renal function.
To measure the burden of pharmacotherapy on patients with type 2 diabetes mellitus (T2DM), we developed Diabetes Treatment Burden Questionnaire (DTBQ), a patient-administered questionnaire composed 18 questions, and evaluated its reproducibility validity. We enrolled 240 T2DM under over 20 years age at seven institutes in Japan. Their physicians filled out report forms patient backgrounds, answered both DTBQ Satisfaction (DTSQ). For evaluation reproducibility, 48 subjects completed 2nd home...
Abstract Aims/Introduction We investigated the effect of FreeStyle Libre TM on glycemic control in Japanese type 2 diabetes patients treated with basal–bolus insulin therapy. Materials and Methods This prospective, 90‐day single‐arm study enrolled 94 adults insulin. A 14‐day masked baseline phase was followed by an 11‐week treatment during which participants used device to monitor glucose levels. The primary end‐point time spent hypoglycemia (<70 mg/dL) for versus end (days 76–90)....
Recent studies have shown that cell transplantation therapies, such as endothelial precursor cells, bone marrow-derived mononuclear cells (BM-MNCs) and mesenchymal stem are effective on diabetic polyneuropathy through ameliorating impaired nerve blood flow in rats. Here, we investigated the effects of BM-MNCs using derived from adult (16-week-old) (AD), non-diabetic (AN) or young (8-week-old) (YN) rats.BM-MNCs AD AN were isolated after an 8-week diabetes duration. The characterized cytometry...
The Internet of Things (IoT) allows collecting vast amounts health-relevant data such as daily activity, body weight (BW), and blood pressure (BP) automatically. use IoT devices to monitor diabetic patients has been studied, but could not evaluate IoT-dependent effects because health were measured in control groups. This multicenter, open-label, randomized, parallel group study will compare the impact intensive guidance using conventional medical on glucose control. It be conducted...
Objective We investigated the efficacy, safety, and patient satisfaction of once-weekly DPP-4 inhibitors (DPP-4Is). Methods Either two DPP-4Is, trelagliptin or omarigliptin, was administered alone in combination with other antidiabetic drugs 80 outpatients type 2 diabetes mellitus for 3 months. The HbA1c, glycoalbumin (GA), body weight, Diabetes Treatment Satisfaction Questionnaire (DTSQ) scores were evaluated. Results Patients switching from daily DPP-4Is (n=29) showed no significant...
Preference for quality of life is important in deciding the treatment strategy patients with type 2 diabetes mellitus. This study aimed to assess effect omarigliptin on patients' psychological attitudes and responses compared daily dipeptidyl peptidase-4 inhibitors (DPP4is) by measuring burden pharmacotherapy using Diabetic Treatment Burden Questionnaire (DTBQ). Patients mellitus who were taking DPP-4is enrolled randomized a group that switched or continued DPP4is monitored 12 weeks. The...
We studied influences of perceptions patients’ wait times and communication behaviors healthcare professionals on treatment satisfaction the intention to drop out in diabetes outpatients. A questionnaire was sent 888 outpatients with or impaired glucose tolerance who visited our clinic April 2016. also measured time spent clinics. Totally, 759 patients responded questionnaire; 717 valid responses were obtained for statistical analyses. In group out,” many replied that they felt “the from...
This study aimed to investigate the effectiveness at 1 and 3 months of using a smaller rice bowl for diet therapy among Japanese men with type 2 diabetes.A parallel-group randomized controlled trial was conducted medical clinic in Japan. The participants were diabetes mellitus, aged 20-80 years, glycosylated hemoglobin <8.5%, who ate one or more times per day home. intervention group (36 men) received small from which eat usual therapy, control (38 only therapy.The changes weight body mass...
A combination drug comprising teneligliptin (Ten) and canagliflozin (Can) became commercially available in Japan September 2017. No studies reported the effect of this on variations blood glucose levels through continuous monitoring with Free Style Libre Pro (Libre Pro). This study prospectively examined effects patients treated either Ten or Can. The subjects were 15 outpatients diabetes HbA1c ranging from 6.5% to 15% who had been 20 mg (10 patients) Can 100 (5 patients). Doses antidiabetes...
No studies have reported changes in self-care behavior, and it remains unclear whether Free Style Libre (Libre) differs from conventional blood glucose self-monitoring devices this regard. Therefore, we instructed diabetes patients using (SMBG) to use the prospectively examined effect of new device on behavior patient treatment satisfaction. The subjects comprised 41 outpatients with who were SMBG devices. randomly assigned group A, which for ≥2 weeks (n = 21), or B, continued 20). All...
Effects of SGLT2 inhibitors (SGLT2i) on renal functions were examined in patients with type 2 diabetes followed by our clinic. Subjects 395 outpatients treated SGLT2i (ipragliflozin 135; empagliflozin 101; canagliflozin 83; dapagliflozin 76; age 51.6 ± 11.3 years; duration 7.21 6.8 BMI 28.6 4.5). Changes eGFR at 1 year before and years after the administration versus baseline retrospectively analyzed groups divided eGFR; eGFR&lt;90 ml/min/1.73m2 group eGFR≧90 group. The changes urinary...
Aims: Efficacy of a GLP-1 receptor agonist, dulaglutide, on renal functions in type 2 diabetic patients under the real-world clinical practice Japan was retrospectively examined. Subjects: 154 with diabetes treated dulaglutide (0.75 mg once weekly) our clinic (mean administration period 540.7 ± 332 days; mean age 58.1 years; duration 10.5 years). Methods: Dulaglutide added to conventional antidiabetes drugs. The dose sulfonylurea reduced by 50-67% and all DPP-4 inhibitors were discontinued....
This study focuses on Japanese type 2 diabetes outpatients with a rice intake higher than the recommended limit. We studied use of smaller-than-conventional bowls in daily life and conducted prospective to assess its impacts adherence recommendations, weight, HbA1c value, DDRQOL scores for 3 months. selected 72 male participants whose current larger guidelines, at home are size. Study were randomly divided into two groups. The intervention group (IG) consisted 36 who asked designated bowl...