A5101768345- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Evolutionary Algorithms and Applications
- Amino Acid Enzymes and Metabolism
- Medical Imaging and Pathology Studies
- Neuroendocrine Tumor Research Advances
- Adrenal and Paraganglionic Tumors
- Cancer Immunotherapy and Biomarkers
- Metaheuristic Optimization Algorithms Research
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Glioma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Neuroblastoma Research and Treatments
- Immunotherapy and Immune Responses
- Pituitary Gland Disorders and Treatments
- Reinforcement Learning in Robotics
- Esophageal Cancer Research and Treatment
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
Gunma University
2016-2025
Gunma University Hospital
2011-2022
Toho University Medical Center Sakura Hospital
2013-2021
Toho University
2013-2021
Segawa Neurological Clinic for Children
2021
Universidade Federal do Rio Grande do Sul
2021
Tokushima University
2021
Massachusetts General Hospital
2021
GTx (United States)
2019-2020
Okayama Red Cross General Hospital
2013-2016
Based on negative correlation learning and evolutionary learning, this paper presents ensembles with (EENCL) to address the issues of automatic determination number individual neural networks (NNs) in an ensemble exploitation interaction between NN design combination. The idea EENCL is encourage different NNs learn parts or aspects training data so that can better entire data. cooperation specialization among are considered during design. This provides opportunity for interact each other...
The anti-programmed cell death-1 monoclonal antibody (mab), nivolumab has recently been approved for the treatment of unresectable or metastatic malignant melanoma and non-small-cell lung cancers in Japan. Ipilimumab, an anti-cytotoxic T lymphocyte antigen-4 mab that was earlier than Western countries, is known to frequently cause endocrine immune-related adverse events such as hypophysitis thyroid dysfunction. We herein report a patient with advanced who appeared develop consequence...
CD40 ligand (CD40L) is ectopically expressed on B cells in patients with systemic lupus erythematosus (SLE) and lupus-prone BXSB mice. To assess the role of ectopic CD40L expression development SLE, we have established transgenic mice expressing cells. Some 12- to 14-mo-old CD40L-transgenic spontaneously produced autoantibodies such as antinuclear Abs, anti-DNA antihistone Abs. Moreover, approximately half developed glomerulonephritis immune-complex deposition, whereas kidneys normal...
A new fucoganglioside, disialosyl Lea, has been found in the disialoganglioside fraction of human colonic adenocarcinoma. The ganglioside isolated from four other disialogangliosides by high-performance liquid chromatography followed preparative thin-layer chromatography. structure antigen was characterized its conversion to lactofucopentaosyl(II)ceramide (Lea-active ceramide pentasaccharide), methylation analysis, and high-mass range electron-impact as well field-desorption mass...
Lately, immune checkpoint proteins, such as programmed death 1 (PD-1) and its ligand-1 (PD-L1), have garnered attention a new target in oral squamous cell carcinoma (OSCC). Reportedly, fluoro-D-glucose (FDG)-uptake alteration by anti-PD-1 antibody treatment depicts the response patients with lung cancer. This study aims to elucidate correlations between tumour status, clinicopathological factors, 18F-FDG-uptake cold phenotypes low PD-L1 expression/low CD8+tumour-infiltrating lymphocytes...
Abstract Background Prurigo nodularis (PN), a chronic inflammatory skin condition, adversely affects the quality of life affected individuals. Current treatment options for PN in Japan are limited. Objectives To evaluate optimal dose, efficacy and safety long-term with nemolizumab patients Japan. Methods In 16-week double-blind phase II/III study, aged ≥ 13 years were randomly assigned (1 : 1 1) to 30-mg, 60-mg or placebo groups, concomitant topical corticosteroids, every 4 weeks. The...
Effective treatments for malignant neuroendocrine tumors are under development. While iodine-131 metaiodobenzylguanidine (131I-MIBG) radiotherapy has been used in the treatment of tumors, there few studies evaluating its therapeutic effects and safety a multicenter cohort. In current study, we sought to evaluate 131I-MIBG therapy conditions including pheochromocytoma paraganglioma within Forty-eight (37 11 paraganglioma) from four centers underwent clinical radiotherapy. The tumor responses...
Cholangiocellular carcinoma (CCC) has been reported to have a high glucose uptake; however, the mechanism of entry into these cells is still unclear. We investigated relationship between [ 18 F]‐2‐fluro‐2‐deoxy‐ d ‐glucose ( F‐FDG) uptake and expression facilitative transporters (Glut) hexokinase (HK) II, as well association different histological types CCC. The Glut (1–5) HK II was studied using immunohistochemistry 26 patients with CCC who underwent whole‐body F‐FDG positron emission...
L-[3-18F]-alpha-methyltyrosine (18F-FMT) is an amino-acid tracer for positron-emission tomography (PET). We have conducted a clinicopathologic study to elucidate the correlation of angiogenesis with 18F-FMT and 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) uptake in patients non-small cell lung cancer (NSCLC). Thirty-seven NSCLC were enrolled this study, two PET studies 18F-FDG performed. Uptake tracers was evaluated standardized value. Vascular endothelial growth factor (VEGF), CD31, CD34,...
Semantic labelling of acoustic scenes has recently emerged as active topic covering a wide range applications, e.g. surveillance and audio-based information retrieval. In this paper, we present an effective approach for scene classification through characterizing both background sound textures events. The work takes inspiration from the psychoacoustic definition scenes, that is, "skeleton (acoustic) events on bed (sound) texture". detail, firstly employ distinct models to exploit in...
Background/Aim: Programmed death-ligand 1 (PD-L1) expression in tumor cells is regulated by a close interrelation between and stromal within the microenvironment. Our aim was to evaluate clinical biological significance of PD-L1 oral squamous cell carcinoma (OSCC). Materials Methods: PD-L1, cluster differentiation (CD)4, CD8, forkhead box P3 (FOXP3) tissues obtained from 77 patients with OSCC evaluated immunohistochemical staining, then analyzed for associations factors. Results: Among...
We assessed the severity of amyloid-β accumulation and white matter lesions (WML) in brain, their association with cognitive decline, patients (n = 47) Alzheimer's disease (AD). The mean cortical standardized uptake value ratio (mcSUVR) was derived from amyloid positron emission tomography, while percentage WML area relative to brain parenchymal determined using magnetic resonance imaging. Cognitive decline positively correlated ( r 0.50, p 0.042) but not mcSUVR (Aβ accumulation). Managing...