A5101465802- Microfluidic and Bio-sensing Technologies
- Robot Manipulation and Learning
- Blood properties and coagulation
- Erythrocyte Function and Pathophysiology
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Soft Robotics and Applications
- 3D Printing in Biomedical Research
- Robotic Mechanisms and Dynamics
- Advanced Combustion Engine Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Platelet Disorders and Treatments
- Cellular Mechanics and Interactions
- Ocular Surface and Contact Lens
- Modular Robots and Swarm Intelligence
- Advanced Sensor and Energy Harvesting Materials
- Robotic Path Planning Algorithms
- Cardiovascular Function and Risk Factors
- Combustion and flame dynamics
- Force Microscopy Techniques and Applications
- Teleoperation and Haptic Systems
- Analytical Chemistry and Sensors
- Lipid Membrane Structure and Behavior
- Antiplatelet Therapy and Cardiovascular Diseases
- Robotic Locomotion and Control
Osaka University
2012-2025
Yokohama City University
2021-2024
Mitsui Memorial Hospital
2024
University of Yamanashi Hospital
2017-2021
Meijo University
2020
The University of Tokyo
2006-2019
Tokyo Medical University
2018-2019
Chiba University
1995-2019
Tokyo Medical University Hospital
2019
Tokyo Medical and Dental University
2014-2017
Red blood cells (RBC) circulate the human body several hundred thousand times in their life span. Therefore, deformability is really important, especially when they pass through a local capillary whose diameter can be as narrow 3 μm. While there have been number of works discussing simulated such microchannel, far we examined literature, no work focusing on change shape after reciprocated mechanical stress has reported so far. One reasons that appropriate experimental systems to achieve...
Background Chronic heart failure (CHF) with preserved left ventricular (LV) ejection fraction (HFpEF) is observed in half of all patients CHF and carries the same poor prognosis as reduced LV (HFrEF). In contrast to HFrEF, there no established therapy for HFpEF. inflammation contributes cardiac fibrosis, a crucial factor HFpEF; however, inflammatory mechanisms mediators involved development HFpEF remain unclear. Therefore, we sought identify novel this process. Methods Results An analysis by...
We studied clinical features and pathologic findings in 52 consecutively autopsied patients with multiple myeloma our center between 1979 1998. Distant extraosseous involvement was found 33 (63.5%). Thirty-one (59.6%) were proven to have infection at autopsy, among which pneumonia most common site of infection. Amyloidosis shown 8 patients. Second malignancies observed 4 cases. The three major causes death hemorrhage, infection, renal failure, accounted for approximately 70% the Advances...
In this paper, a new category of the wheel-leg hybrid robot is presented. The proposed mechanism can compose large wheel diameter compared with previous to realize greater ability climb obstacles. A prototype model one Wheel-Leg module has been developed illustrate concept. Actual design and mode changing experiment test mechanical also Basic movement tests basic properties rotational fingertip are shown. configurations retractable considered well. integrated described.
We have developed a new hydrogel hemostat composed of hyaluronan (HA) conjugated with inorganic polyphosphate (PolyP). A hemostatic hydrogel, HAX-PolyP, was formed rapidly by mixing aldehyde-modified HA and hydrazide-modified PolyP (HA-PolyP). Although the gelation rate decreased increasing content, time below 5 min. In addition, swelling volume but degradation did not depend on content underwent complete through hydrolysis over 3 weeks in phosphate buffered saline. HAX-PolyP showed similar...
Patients with refractory cardiogenic shock (CS) necessitating peripheral veno-arterial extracorporeal membrane oxygenation (VA-ECMO) often require an intra-aortic balloon pump (IABP) or Impella for unloading; however, comparative effectiveness data are currently lacking.
Radioactive Cs isotopes (137Cs, t1/2 = 30.07 y and 134Cs, 2.062 y) occur in severely contaminated soils within a few km of the Fukushima Dai-ichi nuclear power plant at concentrations that range from 4×10^5 to 5×10^7 Bq/kg. In order understand mobility these soils, both bulk submicron-sized particles elutriated four surface have been investigated using variety analytical techniques, including powder X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), amount radioactivity...
The integrin alpha(IIb)beta(3) plays a critical role in mediating clot retraction by platelets which is important vivo consolidating thrombus formation. Actin-myosin interaction essential for retraction. In the present study, we demonstrate that structurally distinct Src kinase inhibitors, PP2 and PD173952, significantly reduced rate of retraction, but did not prevent it reaching completion. This effect was accompanied abolition alpha(IIb)beta(3)-dependent protein tyrosine phosphorylation,...
This paper discusses dynamic manipulation inspired by the handling mechanism of a pizza chef. The chef handles tool called ldquopizza peel,rdquo where plate is attached at tip bar, and he remotely manipulates on plate. We found that aggressively utilizes only two degrees freedom (DOFs) from remote location during manipulation: translation along bar rotation about bar. From viewpoint system, inertial loads for these specific DOFs are never affected length important production quick motions so...
This paper discusses an active shaping method for unknown rheological object by considering the characteristics of viscoelasticity. By utilizing a four-element model approximating dynamic object's deformation, we drive deformation decomposition into elastic response and plastic one. For object, then propose two-phase strategy controlling resultant deformation; in first phase viscoelastic parameters are estimated with avoiding over based on response; second desired is generated actively...
Abstract Large deformability of erythrocytes in microvasculature is a prerequisite to realize smooth circulation. We develop novel tool for the three-step “Catch-Load-Launch” manipulation human erythrocyte based on an ultra-high speed position control by microfluidic “robotic pump”. Quantification shape recovery as function loading time uncovered critical window transition between fast and slow recoveries. The comparison with under depletion adenosine triphosphate revealed that cytoskeletal...
An on-chip deformability checker is proposed to improve the velocity–deformation correlation for red blood cell (RBC) evaluation. RBC has been found related human diseases, and can be evaluated based on velocity through a microfluidic constriction as in conventional approaches. The between transit amount of deformation provides statistical information deformability. However, such correlations are usually only moderate, or even weak, practical evaluations due limited range deformation. To...
Abstract Shortage of autologous blood vessel sources and disadvantages synthetic grafts have increased interest in the development tissue-engineered vascular grafts. However, tunica media, which comprises layered elastic laminae, largely determines arterial elasticity, is difficult to synthesize. Here, we describe a method for fabrication with layer structure from cultured human SMCs by periodic exposure extremely high hydrostatic pressure (HP) during repeated cell seeding. Repeated slow...
Although the mouse heart failure (HF) model of hypertensive disease (HHD) is useful to investigate pathophysiology and new therapeutic targets for HHD, using simple experimental procedures stable phenotypes has not been established. This study aimed develop a novel HF HHD by combining salt loading uninephrectomy with ANG II infusion. Eight-week-old C57BL/6 male mice were treated infusion (AT), (AN), (AS), or infusion, uninephrectomy, (ANS). Systolic blood pressure was significantly elevated...