A5073561843- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Lymphoma Diagnosis and Treatment
- HIV/AIDS oral health manifestations
- Non-Invasive Vital Sign Monitoring
- Chronic Lymphocytic Leukemia Research
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Chronic Myeloid Leukemia Treatments
- COVID-19 Clinical Research Studies
- Fungal Infections and Studies
- Heart Rate Variability and Autonomic Control
- Streptococcal Infections and Treatments
- SARS-CoV-2 detection and testing
- Blood Pressure and Hypertension Studies
- Pleural and Pulmonary Diseases
- Ultrasound in Clinical Applications
- Liver Disease Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Cardiovascular Syncope and Autonomic Disorders
- NF-κB Signaling Pathways
- Pharmacological Effects and Toxicity Studies
- Lung Cancer Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Allergic Rhinitis and Sensitization
University of Tokyo Health Sciences
2017-2024
The University of Tokyo
2015-2024
University of Tokyo Hospital
2009-2021
National Institute of Infectious Diseases
2015
Tokyo University of the Arts
2012
Japan Science and Technology Agency
2009-2010
Yamaguchi University
1996-1997
The mechanisms by which lipopolysaccharide (LPS) is recognized, and how such recognition leads to innate immune responses, are poorly understood. Stimulation with LPS induces the activation of a variety proteins, including mitogen-activated protein kinases (MAPKs) NF-κB. Activation tyrosine (PTKs) also necessary for number biological responses LPS. We used murine macrophage-like cell line, RAW264.7, demonstrate that Janus kinase (JAK)2 phosphorylated immediately after stimulation....
The beneficial effects of exercise on reducing the risk cardiovascular disease are established. However, potential interaction between genetic for type 2 diabetes and physical activity outcomes remains elusive. We aimed to investigate effect risk-physical in individuals with diabetes. Using UK Biobank cohort, we investigated three-point four-point major adverse events (MACE), 25 701 diabetic participants. used a polygenic score (PRS_T2D) as measure observed significant PRS_T2D (three-point...
The molecular mechanisms by which pathogen-associated patterns recognized TLR2, such as peptidoglycan (PGN), induce homotolerance are largely unknown. It was recently reported that IRAK-M negatively regulates TLR signaling. In this study, we elucidate the of tolerance induced PGN, with a focus on role IRAK-M. We demonstrate pretreatment macrophage RAW264.7 cells high concentration (30 μg/ml) PGN for 16 h effectively induces against following stimulation 30 μg/ml PGN; while low (1 does not....
Abstract Recurrent hotspot (p.Gly17Val) mutations in RHOA encoding a small GTPase, together with loss-of-function TET2 an epigenetic regulator, are genetic hallmarks of angioimmunoblastic T-cell lymphoma (AITL). Mice expressing the p.Gly17Val mutant on Tet2-null background succumbed to AITL-like lymphomas due deregulated receptor (TCR) signaling. Using these mice investigate therapeutics for AITL, we found that dasatinib, multikinase inhibitor prolonged their survival through inhibition...
Continuous monitoring of eating habits could be useful in preventing lifestyle diseases such as metabolic syndrome. Conventional methods consist self-reporting and calculating mastication frequency based on the myoelectric potential masseter muscle. Both these are significant burdens for user. We developed a non-invasive, wearable sensing system that can record over long period time daily life. Our is composed two bone conduction microphones placed ears send internal body sound data to...
This study aimed to compare the clinical characteristics and prognoses of central venous catheter-associated bloodstream infections (CVC-BSIs) with peripheral BSIs (PVC-BSIs).This retrospective observational was conducted between April 2011 March 2013 at a teaching hospital in Tokyo, Japan. Adult patients who developed CVC-BSIs PVC-BSIs more than 2 days after admission were included. Patients both excluded. Clinical obtained from medical records, 30-day all-cause mortality measured as...
Background: Epidemiologic studies provide broad-based evidence that males are at greater risk of severe periodontal diseases than females. Our recent findings further revealed male gender was an independent factor for gingival bleeding in late adolescents Japan. Gingival health status has been reported to be affected by oral hygiene behavior. However, difference this regard not yet clarified. Methods: We conducted a retrospective review mandatory medical questionnaires administered as part...
Abstract Several clinical trials have shown that the humoral response produced by anti-spike antibodies elicited coronavirus disease 2019 (COVID-19) vaccines gradually declines. The kinetics, durability and influence of epidemiological factors on cellular immunity not been fully elucidated. We analyzed immune responses BNT162b2 mRNA in 321 health care workers using whole blood interferon-gamma (IFN-γ) release assays. IFN-γ, induced CD4 + CD8 T cells stimulated with severe acute respiratory...
Adipose tissue is central to regulation of energy homeostasis. Adaptive thermogenesis, which relies on mitochondrial oxidative phosphorylation (Ox-Phos), dissipates counteract obesity. On the other hand, chronic inflammation in adipose linked type 2 diabetes and Here, we show that nuclear factor I-A (NFIA), a transcriptional regulator brown beige adipocytes, improves glucose homeostasis by upregulation Ox-Phos reciprocal downregulation inflammation. Mice with transgenic expression NFIA...
The purpose of this study is to demonstrate the use a deep learning model in quantitatively evaluating clinical findings typically subject uncertain evaluations by physicians, using binary test results based on routine protocols. A chest X-ray most commonly used diagnostic tool for detection wide range diseases and generally performed as part regular medical checkups. However, when it comes that can be classified within normal but are not considered disease-related, thresholds physicians’...
Continuous monitoring of blood pressure in daily life could improve early detection cardiovascular disorders, as well promoting healthcare. Conventional ambulatory (ABPM) equipment can measure at regular intervals for 24 hours, but is limited by long measuring time, low sampling rate, and constrained posture. In this paper, we demonstrate a new method continuous real-time measurement during activities. Our based on estimation from pulse wave velocity (PWV) calculation, which formula improved...
Angioimmunoblastic T-cell lymphoma (AITL) and peripheral lymphoma, not otherwise specified (PTCL-NOS) are subtypes of lymphoma. Due to low tumor cell content substantial reactive infiltration, these lymphomas sometimes mistaken for other types or even non-neoplastic diseases. In addition, a significant proportion PTCL-NOS cases reportedly exhibit features AITL (AITL-like PTCL-NOS). Thus disagreement is common in distinguishing between PTCL-NOS. Using whole-exome subsequent targeted...
Adverse reactions after vaccination with COVID-19 mRNA vaccines are common; however, the association between adverse and humoral responses is uncertain. To determine whether immune BNT162b2 vaccine administration were associated local systemic reactions, we conducted a prospective observational cohort study in single tertiary referral center. Healthcare workers who received first dose of recruited. SARS-CoV-2 anti-spike IgG antibody titers measured three weeks second information about was...
Though it is well known that periodontal diseases are associated with various systemic in adults, the associations late adolescents have not been adequately elucidated. We investigated association between gum bleeding (a major symptom of diseases) and common adolescents: allergic, respiratory, otorhinolaryngologic diseases.We conducted a retrospective review mandatory medical questionnaires administered as part legally required freshman checkup April 2017 2019 at University Tokyo. Among...
Flagellin, the structural component of bacterial flagella, is secreted by pathogenic and commensal bacteria, recognized Toll-like receptor (TLR) 5. Flagellin a common antigen present on most motile bacteria speculated to contribute activation CD4+ T cells in intestine. However, molecular mechanisms which flagellin regulate cell remains be determined. Using Jurkat or human primary cell, we showed that stimulation induced tyrosine phosphorylation TLR5 both mitogen-activated protein kinases...
Patients with primary spontaneous pneumothorax (PSP) usually complain of sudden-onset dyspnea and pleuritic chest pain. However, asymptomatic PSP has been incidentally detected on X-rays. In this study, we analyzed the incidence, characteristics, risk factors, prognosis during regular medical check-ups in university students. 101,709 X-rays were performed for students at University Tokyo between April 2011 March 2016. Among them, 43 cases (0.042%) detected. We calculated lung collapse rate...
Although pleural thickening is a common finding on routine chest X-rays, its radiological and clinical features remain poorly characterized.Our investigation of 28,727 X-rays obtained from annual health examinations confirmed that was the most abnormal finding.In cases (92.2%), involved apex lung, particularly right side; thus, it defined as pulmonary apical cap.Pleural more in males than females current smokers or ex-smokers never smokers.The prevalence increased with age, ranging 1.8%...