A5103228135- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Lignin and Wood Chemistry
- Ear Surgery and Otitis Media
- Sinusitis and nasal conditions
- Hepatitis B Virus Studies
- Analytical chemistry methods development
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nasal Surgery and Airway Studies
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Ear and Head Tumors
- Reproductive Biology and Fertility
- Diabetes Treatment and Management
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic function and diabetes
- Ovarian function and disorders
- Metabolism, Diabetes, and Cancer
- Liver physiology and pathology
- Head and Neck Anomalies
- Abdominal Surgery and Complications
Akita University
2011-2024
Hiroshima City Asa Citizens Hospital
2016-2024
University of Miyazaki
2013-2024
Sasebo City General Hospital
2022-2024
Hokuto Hospital
2012-2023
Suzuki (Japan)
2021
Weatherford College
2021
Miyazaki Prefectural Hospital
2016-2018
Ministry of Health Labour and Welfare
2018
Koga Hospital
2005-2018
To determine causes of interindividual variation in insulin requirements, we recruited 20 type 2 diabetic patients with stable glucose control and doses for >1 year on combination therapy bedtime NPH metformin. Insulin absorption (increase free total over 8 h after a subcutaneous dose regular insulin) actions intravenous (6-h 0.3 mU x kg(-1) min(-1) euglycemic clamp combined [3-3H]glucose) (glucose infusion rate required to maintain isoglycemia suppression fatty acids [FFAs]) insulin,...
Abstract We examined the epidemiological trends, including distribution of sex, age, and disease etiology, in HCC incident cases, over 24 years. Data 20,547 patients (1996–2019) were analyzed this prospective study. divided study period into four 6-yearly quarters. etiology was categorized as hepatitis B virus (HBV) infection, HBV + C (HCV) HCV both negative (non-BC). The cases per quarter 4311 (21.0%), 5505 (26.8%), 5776 (28.1%), 4955 (24.1%), sequentially. Overall, 14,020 (68.2%) male....
Several clinical studies have suggested a possible link between chronic hepatitis caused by C virus (HCV) and the development of diabetes mellitus. We investigated association liver fibrosis glucose intolerance in HCV-infected patients measuring insulin sensitivity beta-cell function.A total 83 were recruited into this study. evaluated function all fasting state (homeostasis model assessment resistance [HOMA-R] homeostasis [HOMA-beta]) after an oral load 75 g (whole-body index [WBISI]...
Objective Pancreatic cancer is one of the most malignant diseases worldwide. Interferon regulatory factor (IRF) 1 and IRF2 function as a tumor suppressor oncoprotein, respectively, in several types cancers. We investigated whether IRF1 are involved progression pancreatic cancer. Methods examined expressions specimens analyzed association with clinicopathologic features. evaluated biological effects using cell line. Results The expression levels were decreased increased, cells compared those...
Polyembryoma of ovary producing alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) was studied by indirect immunoperoxidase method for AFP HCG, electron microscopy. Clinically, this patient showed pseudoprecocious puberty caused elevated HCG which is synthesized trophoblastic cells in polyembryoma. She put under VAC (vincristine, actinomycin-D, cyclophosphamide) chemotherapy after operation shows no signs recurrence including reelevation serum at five months operation. Embryoid...
Local recurrence after radiofrequency ablation (RFA) is a major problem that needs to resolved increase the survival rate of hepatocellular carcinoma (HCC). CE-US with Sonazoid(®), second-generation contrast media, can detect smaller HCC lesions and detection ultrasonically unrecognized hypervascular was improved by CE-US. The aim present study evaluate role Sonazoid(®) in improving radicality reducing local RFA for HCC.A total 102 nodules treated at our hospital from January 2006 October...
The Japanese severity criteria for acute pancreatitis (AP), which consist of a prognostic factor score and contrast-enhanced computed tomography grade, have been widely used in Japan.This large multicenter retrospective study was conducted to validate the predictive value mortality complications severe AP patients comparison Acute Physiology Chronic Health Evaluation II (APACHE II) score.Data 1159 diagnosed with according were retrospectively collected 44 institutions.The area under curve...
Abstract Delirium is a critical challenge in the intensive care unit (ICU) or high (HCU) setting and associated with poor outcomes. There not much literature on how many patients this are assessed for delirium what tools used. This study investigated status of assessment ICU/HCU. We conducted multicenter prospective observational among 20 institutions. Data who were admitted to discharged from ICU/HCU during 1-month period collected each institution using survey sheet. The primary outcome...
Abstract Although aberrations of intracellular vesicle transport systems towards lysosomes including autophagy and endocytosis are involved in the onset progression acute pancreatitis, molecular mechanisms underlying such remain unclear. The pathways closely related, Rab7 plays crucial roles both. In this study, we analyzed function pancreatitis using pancreas-specific knockout (Rab7 Δpan ) mice. pancreatic acinar cells, maturation steps both endosomes autophagosomes were deteriorated,...
Proliferation, differentiation, and morphogenesis of the intestinal epithelium are tightly regulated by a number molecular pathways. Coordinated action intestine is achieved gastrointestinal hormones, most which exert these actions through G-protein-coupled receptors. We herein investigated role Gαq/11-mediated signaling in homeostasis.Intestinal tissues from control (Gnaqflox/floxGna11+/+ ), Int-Gq knock-out (KO) (VilCre+/-Gnaqflox/floxGna11+/+ G11 KO (Gnaqflox/floxGna11-/- Int-Gq/G11...
Objective Antimicrobial prophylaxis is not generally recommended for patients with severe acute pancreatitis (SAP) owing to the limited clinical benefits. Nonetheless, it frequently administered in actual practice given patients' critical condition and lack of solid evidence showing adverse effects antimicrobial prophylaxis. We evaluated herein an association between invasive pancreatic candidiasis as effect SAP. Methods This a retrospective cohort study all consecutive SAP who were admitted...
Background Cervical lymphadenopathy is a symptom that frequently seen among outpatients, and it important to differentiate malignant lesions from reactive lymphoid hyperplasia. Fine needle aspiration (FNA) cytology has been widely used for the diagnosis of cervical lymphadenopathy. However, some limitations diagnostic accuracy using conventional smear (CS) have pointed out. The value liquid‐based (LBC) with FNA specimens not yet fully proven. Methods Forty‐two patients who underwent CS 2007...
Objectives In patients with severe acute pancreatitis (SAP), early enteral nutrition (EN) is recommended by major clinical practice guidelines, but the exact timing for initiation of EN unknown. Methods We conducted a post hoc analysis database multicenter (44 institutions) retrospective study SAP in Japan. The were classified into 3 groups according to after diagnosis SAP: within 24 hours, between and 48 more than hours. primary outcome was in-hospital mortality. Results Of 1094 patients,...
A 56-year-old male visited our hospital for evaluation of an occipital mass.Contrast computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass liver.Magnetic resonance imaging bone metastasis thoracic vertebrae.Assays hepatitis B surface antigen core antibody were positive his liver condition was Child-Pugh grade A. Our diagnosis hepatocellular carcinoma (HCC) vertebrae metastases on chronic B. He treated radiation therapy transcatheter...
Abstract Background and Aims Mortality after sustained virological response (SVR) with interferon‐free direct‐acting antiviral (IFN‐free DAA) therapy is crucial for optimizing post‐SVR patient care, but it remains unclear, especially regarding non‐liver‐related mortality. Methods Consecutive patients from 14 institutions were stratified into three cohorts: A (without advanced fibrosis without prior HCC), B (with C (curative HCC treatment). We assessed mortality (per 1000 person‐years...