A5113564437- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Neuropeptides and Animal Physiology
- Sexual Differentiation and Disorders
- Nitric Oxide and Endothelin Effects
- Adrenal Hormones and Disorders
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Pituitary Gland Disorders and Treatments
- Receptor Mechanisms and Signaling
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Metabolism, Diabetes, and Cancer
- Stress Responses and Cortisol
- Gastrointestinal disorders and treatments
- Adipose Tissue and Metabolism
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Liver Disease and Transplantation
- Acute Myeloid Leukemia Research
- Liver physiology and pathology
- Diabetes Treatment and Management
Kyushu University
2005-2025
SK Group (Japan)
2025
Seiwa Hospital
2014-2020
Fukuoka Hospital
2017-2020
Fukuoka Prefectural University
2008-2012
Japan Science and Technology Agency
2000-2004
Science and Technology Corporation (United States)
2003-2004
National Hospital Organization Kyushu Cancer Center
1988-2004
Fukuoka City Hospital
2002
National Kyushu Medical Center
2002
Abstract In previous studies, we have shown that murine CD4+CD25+ regulatory T cells produce high levels of TGF-β1 in a cell surface and/or secreted form, and blockade such by anti-TGF-β curtails the ability these to suppress CD25− proliferation B Ig production vitro suppressor assays. further support for role suppression cells, show this study another TGF-β1-blocking molecule, recombinant latency-associated peptide (rLAP), also reverses mouse as well their human counterparts, CD4+CD25high...
Adipose differentiation-related protein (ADRP) is a lipid droplet-associated that expressed early during adipose differentiation. The present study was undertaken to reveal the role of ADRP in In murine fibroblasts infected with green fluorescent (GFP)-ADRP fusion expression adenovirus vector, confocal microscopic analysis showed number and size droplets apparently increased comparing those control cells. Overexpressed GFP-ADRP were mainly located at surface appeared be “ring-shaped.”...
Atrazine is a potent endocrine disruptor that increases aromatase expression in some human cancer cell lines. The mechanism involves the inhibition of phosphodiesterase and subsequent elevation cAMP.
Androgen receptor (AR) null male mice (ARL−/Y) revealed late-onset obesity, which was confirmed by computed tomography–based body composition analysis. ARL−/Y were euphagic compared with the wild-type (ARX/Y) controls, but they also less dynamic and consumed oxygen. Transcript profiling indicated that had lower transcripts for thermogenetic uncoupling protein 1, subsequently found to be ligand-dependently activated AR. We enhanced secretion of adiponectin, is insulin sensitizing, from...
Ghrelin, an acylated brain and gut peptide, is primarily produced by endocrine cells of the gastric mucosa for secretion into circulation. The major active form ghrelin a 28-amino-acid peptide containing n-octanoyl modification at serine that essential activity. Studies have identified multiple physiological functions ghrelin, including GH release, appetite stimulation, metabolic fuel preference. Until now, there has not been any report detailing mechanism acyl modification. Here we...
Obesity is associated with insulin resistance and some reproductive abnormalities. Circulating FFAs are often elevated in obese subjects also closely linked to resistance. In this study, we demonstrated that saturated FFAs, such as palmitic acid stearic acid, markedly suppressed the granulosa cell survival a time- dose-dependent manner. Polyunsaturated FFA, arachidonic had no effect on survival, even at supraphysiological concentrations. The suppressive of was caused by apoptosis, evidenced...
OBJECTIVE To identify novel type 2 diabetes gene variants and confirm previously identified ones, a three-staged genome-wide association study was performed in the Japanese population. RESEARCH DESIGN AND METHODS In stage 1 scan, we genotyped 519 case 503 control subjects with 482,625 single nucleotide polymorphism (SNP) markers; panel comprising 1,110 1,014 subjects, assessed 1,456 SNPs (P < 0.0025, 1); additionally to direct genotyping, 964 healthy formed silico panel. Along...
Oxidative stress may contribute to the pathogenesis of diabetic nephropathy. However, detailed molecular mechanism remains uncertain. Here, we report oxidative mitochondrial DNA (mtDNA) damage and accumulation mtDNA with a 4,834-bp deletion in kidney streptozotocin-induced rats. At 8 weeks after onset diabetes, levels 8-hydroxy-2′-deoxyguanosine (8-OHdG), which is marker damage, were significantly increased from rats but not nuclear DNA, suggesting predominant mtDNA. Semiquantitative...
Abstract Natural killer (NK) cell lymphomas/leukemias are highly aggressive lymphoid malignancies, but little is known about their genomic alterations, and thus there an urgent need for identification analysis of NK lymphomas/leukemias. Recently, we developed our own array‐based comparative hybridization (array CGH) with average resolution 1.3 Mb. We performed array CGH 27 NK‐cell lymphoma/leukemia cases that were classified into two disease groups based on the World Health Organization...
We have investigated the effect of glucose on release endothelin‐1‐like immunoreactivity (ET‐l‐LI) from cultured bovine aortic endothelial cells. Elevation concentrations in media 5.5 to 11.1 or 22.2 mM significantly stimulated ET‐1‐LI An aldose reductase inhibitor did not affect high glucose‐induced release, These findings suggest possibility that hyperglycemia diabetic patients enhances at local site vascular endothelium. which might be involved developments complications and atherosclerosis.
To examine the effect of age on secretion and action human atrial natriuretic polypeptide (hANP), we compared plasma cGMP concentrations in 19 normal young (24–28 yr old) 31 elderly (64–91 men. The mean basal hANP level was 25 ± 5 (±sem) pg/ml men 120 22 (P < 0.01). molecular size an aged man similar to that ahANP. responses iv infusion 500 ml 0.15 M NaCl also compared. Mean increased significantly both groups, response exaggerated However, increases during loading were groups. We conclude...
Whether brachial-ankle pulse wave velocity (baPWV), a noninvasive marker for arterial stiffness, is useful predictive maker cardiovascular events in subjects with diabetes not established. In the present cohort study, we evaluated benefit of baPWV prediction morbidity and mortality diabetes.A total 4,272 outpatients were enrolled Kyushu Prevention Study Atherosclerosis. Of these, 3,628 subjects, excluding those an ankle-brachial index <0.9, prospectively followed 3.2 ± 2.2 years. The at...
Androgen-insensitivity syndromes in 46,XY fetuses result various degrees of impairment genital virilization.1 These are caused by mutations the androgen receptor gene that decreased binding to receptor.2–9 As a consequence, transcriptional activity androgen–androgen-receptor complex is reduced, and therefore, virilization reduced. The receptor, like other steroid hormone receptors, has two major transactivation domains10 — activation function 1 (AF-1) N-terminal region11–13 2 (AF-2)...
Recently, intraductal papillary-mucinous tumor (IPMT) of the pancreas has increasingly been recognized. However, differential diagnosis between benign and malignant IPMT is often difficult using conventional imaging modalities. The purpose this study was to retrospectively investigate value endoscopic ultrasonography (EUS) for differentiating from IPMT.A total 51 patients with were preoperatively examined by EUS. endosonograhic findings compared histopathological resected specimens.In main...
Hyperglycemia and diabetes have been shown to increase diacylglycerol (DAG) level activate protein kinase C (PKC) activity in the vascular tissues, possibly altering function. We characterized effects of D-α-tocopherol (vitamin E) on PKC activities DAG levels rat aortic smooth muscle cells (ASMCs) cultured with elevated glucose as well tissues obtained from control diabetic rats. In ASMCs, specific membraneous fraction total were increased by 31 ± 4% (P &lt; 0.05) 50 7% 0.05),...