A5049907166- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Blood Pressure and Hypertension Studies
- Potassium and Related Disorders
- Muscle and Compartmental Disorders
- Renal Transplantation Outcomes and Treatments
- Angiogenesis and VEGF in Cancer
- Iron Metabolism and Disorders
- Magnesium in Health and Disease
- Renal and Vascular Pathologies
- Central Venous Catheters and Hemodialysis
- Peripheral Artery Disease Management
- Nutrition and Health in Aging
- Diabetes Treatment and Management
- Neurological and metabolic disorders
- Electrolyte and hormonal disorders
- Pharmacological Effects and Toxicity Studies
- Acute Kidney Injury Research
- Vitamin D Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Lymphatic System and Diseases
- Liver Disease Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
Kyushu University
2016-2025
Harvard University
2015-2025
Brigham and Women's Hospital
2015-2025
Kyushu University Hospital
2018-2024
Kitakyushu City Hospital Organization
2024
Kyushu Hospital
2024
National Kyushu Medical Center
2023
Nara Medical University Hospital
2023
Center for Excellence in Education
2018-2022
St. Luke's International University
2021
Chronic kidney disease (CKD) increases cardiovascular risk. Underlying mechanisms, however, remain obscure. The uremic toxin indoxyl sulfate is an independent risk factor in CKD. We explored the potential impact of on proinflammatory activation macrophages and its underlying mechanisms.We examined vitro effects clinically relevant concentrations responses roles organic anion transporters transporting polypeptides (OATPs). A systems approach, involving unbiased global proteomics,...
Hyperphosphatemia contributes to increased cardiovascular mortality through vascular calcification (VC) in patients with chronic kidney disease (CKD). Malnutrition and inflammation are also closely linked an risk of death CKD. However, the effects P i overload on malnutrition remain be elucidated. The aim present study was investigate dietary loading interactions among inflammation, malnutrition, VC We used control rats fed normal diets adenine-induced CKD different concentrations ranging...
Blood urea nitrogen (BUN) is one of the substances that affects calculated serum osmolality (cSosm). A previous study demonstrated BUN and cSosm were independently associated with development chronic kidney disease (CKD) in patients preserved function. In advanced CKD stages, there a concomitant increase levels. However, it remains unclear whether or levels are related to renal outcomes moderate severe dysfunction. The aim this was clarify level progression CKD. prospective study, we...
Several studies have shown that the neutrophil/lymphocyte ratio (NLR) is a marker reflects state of systemic inflammation. A high NLR was reported to be associated with cardiovascular events and mortality. However, little known about association between kidney disease progression in patients chronic (CKD). Therefore, aim present study determine whether renal outcomes CKD patients.This prospective observational included 350 consecutive stage 1-4 treated June 2009 November 2016. Data were...
Abstract The geriatric nutritional risk index (GNRI) and creatinine (Cr) are indexes often used as surrogates in patients receiving hemodialysis. However, few studies have directly compared the clinical characteristics of these two indexes. We investigated 3,536 hemodialysis enrolled Japan DOPPS phases 4 5. primary outcome was all-cause mortality main exposures were GNRI Cr index. confirmed association between estimated by a multivariable-adjusted Cox proportional hazards model. During...
Randomized controlled trials have shown kidney-protective effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors, and clinical practice databases suggested that these translate to practice. However, long-term efficacy, as well whether the presence or absence proteinuria rate estimated glomerular filtration rates (eGFR) decline prior SGLT2 inhibitor initiation modify treatment efficacy among type diabetes mellitus (T2DM) chronic kidney disease (CKD) patients, is unknown.Using Japan...
Background: Activated macrophages contribute to the pathogenesis of vascular disease. Vein graft failure is a major clinical problem with limited therapeutic options. PCSK9 (proprotein convertase subtilisin/kexin 9) increases low-density lipoprotein (LDL)-cholesterol levels via LDL receptor (LDLR) degradation. The role in macrophage activation and vein largely unknown, especially through LDLR-independent mechanisms. This study aimed explore novel mechanism disease induced by circulating an...
Background and hypothesis: Multimorbidity, defined as the presence of two or more chronic conditions, is associated with poor outcomes increased cardiovascular risk in general population. However, effect multimorbidity on patients kidney disease (CKD), a group already at high for disease, not well understood. Methods: We analysed data from 4420 non-dialysis CKD enrolled Fukuoka Kidney Registry Study. identified 23 comorbidities, including cardiometabolic non-cardiometabolic conditions. The...
Renal fibrosis is the final common pathway of chronic kidney diseases. Lymphatic vessel (LV) proliferation found in human renal diseases and other fibrotic diseases, suggesting that lymphangiogenesis associated with progression or suppression However, purpose LV not completely understood. We investigated effect vascular endothelial growth factor (VEGF)-C on lymphangiogenesis, inflammation, mouse using unilateral ureteral obstruction (UUO) model. In UUO mice, significant LVs was accompanied...
Abstract It is widely accepted that angiogenesis required for tumor progression. Vascular endothelial growth factor (VEGF) a key molecule angiogenesis; however, its expressional regulation not well understood during all stages of tumorigenesis. Using cell lines and surgical specimens human non–small lung cancers (NSCLCs), we here show platelet-derived factor-AA (PDGF-AA) an essential autocrine regulator VEGF expression. To directly assess the expression PDGF-AA–dependent roles in...
Chronic kidney disease (CKD) is frequently associated with uremic encephalopathy and cognitive impairment. Recent studies have demonstrated that cerebral oxidative stress contributes to dysfunction. Although has been reported increase in the rat brain, relationship between increased impairment uremia unclear. In present study, effects of tempol (TMP), an antioxidant drug, were investigated mice. CKD was induced male C57BL/6 mice (n = 8) by left nephrectomy 2/3 electrocoagulation right renal...
Evidence suggests that cardiac remodeling, including left ventricular hypertrophy and myocardial fibrosis, develops with progression of kidney disease. Few studies have examined pathology across a range estimated glomerular filtration rates (eGFRs), which was the objective this investigation.Population-based cross-sectional study deceased patients undergoing autopsy.334 694 consecutive autopsy available tissue, prior health examination within 6 years without diagnosis heart disease.eGFR.The...
Abstract Kidney metabolism may be greatly altered in chronic kidney disease. Here we report that arginine is the most unilateral ureteral obstruction (UUO)-induced fibrosis of kidneys metabolomic analysis. Spermidine increased metabolite arginine. In human glomerulonephritis, amount spermidine shown by immunostaining associated with fibrosis. proximal tubule cells, induces nuclear factor erythroid 2-related 2 (Nrf2). Subsequently, fibrotic signals, such as transforming growth β1 secretion,...
Objective— Monocyte chemoattractant protein-1 (MCP-1) is a C-C chemokine that known as an inflammatory/arteriogenic factor. Angiogenesis contributes to the inflammatory process; however, molecular and cellular mechanisms of links among pathway, arteriogenesis, angiogenesis have not been well elucidated. Methods Results— Using murine models fibroblast growth factor-2 (FGF-2)–mediated therapeutic neovascularization, we here show FGF-2 targets nonendothelial mesenchymal cells (NEMCs) enhancing...
Objective— Despite its large clinical impact, the underlying mechanisms for vein graft failure remain obscure and no effective therapeutic solutions are available. We tested hypothesis that Notch signaling promotes disease. Approach Results— used 2 biotherapeutics Delta-like ligand 4 (Dll4), a ligand: (1) blocking antibody (2) macrophage- or endothelial cell (EC)–targeted small-interfering RNA. Dll4 administration 28 days inhibited lesion development in low-density lipoprotein (LDL)...
HT1 (HIGH LEAF TEMPERATURE 1) is the first component associated with changes in stomatal aperture response to CO2 be isolated by forward genetic screening. The gene encodes a protein kinase expressed mainly guard cells. loss-of-function ht1-1 and ht1-2 mutants Arabidopsis thaliana have CO2-hypersensitive closure concomitant reductions their activities vitro. In addition these mutants, this study we isolate or obtaine five new ht1 alleles (ht1-3, ht1-4, ht1-5, ht1-6, ht1-7). Among only ht1-3...