A5045224584- Face and Expression Recognition
- Neural Networks and Applications
- Liver Disease Diagnosis and Treatment
- Gene expression and cancer classification
- Image Retrieval and Classification Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Handwritten Text Recognition Techniques
- Spectroscopy and Chemometric Analyses
- RNA modifications and cancer
- Industrial Vision Systems and Defect Detection
- Traditional Chinese Medicine Studies
- Bioinformatics and Genomic Networks
- Medical Image Segmentation Techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Gastric Cancer Management and Outcomes
- Image and Object Detection Techniques
- Image Processing and 3D Reconstruction
- Infrastructure Maintenance and Monitoring
- Radiomics and Machine Learning in Medical Imaging
- Dental Radiography and Imaging
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- AI in cancer detection
- Fuzzy Logic and Control Systems
- Hepatitis B Virus Studies
Yamaguchi University
2015-2024
Yamaguchi University Hospital
2022
Kawasaki Medical School
2022
Niigata University
2021
Kitasato University
2012
National Institute of Technology, Ube College
2012
Sanyo (Japan)
2010
Hyogo Prefectural Awaji Medical Center
1999-2002
Committee on Publication Ethics
2000
Hyogo Prefectural Police
2000
Recently, interest in automatic crack detection on concrete structure images for non-destructive inspection has been increasing. In general, there are various noises such as irregularly illuminated conditions, shading, blemishes and divots the images. These lead to difficulties detection. This paper presents two p re-processings order remove First, slight variations like conditions shading removed from by subtraction pre-processing with smoothed image. Secondly, a line filter based Hessian...
We developed a new, easy, and objective method to detect gastric cancer using hyperspectral imaging (HSI) technology combining spectroscopy A total of 16 gastroduodenal tumors removed by endoscopic resection or surgery from 14 patients at Yamaguchi University Hospital, Japan, were recorded camera (HSC) equipped with HSI Corrected spectral reflectance was obtained 10 samples normal mucosa for each case The cases divided into eight training (160 samples) test established diagnostic algorithm...
An increased level of glycolysis, an intracellular hallmark neoplasms, enables cancer cells to survive under various conditions. To elucidate the role glycolysis in progression hepatocellular carcinoma (HCC), we investigated associations between expression patterns 14 glycolysis-related genes and clinicopathologic factors 60 HCCs by using pooled transcriptome data. We then evaluated therapeutic efficacy knockdown ENO1, which is encoded a gene, HCC cells. Among genes, levels 8 (GPI, ALDOA,...
Abstract The current study was conducted to identify robust methylation markers and their combinations that may prove useful for the diagnosis of early hepatocellular carcinoma (HCC). To achieve this, we performed in silico CpG mapping, direct sequencing pyrosequencing after bisulfite treatment, quantitative methylation‐specific PCR (MSP) HCC non‐HCC liver tissues. In filtering group (25 HCCs), our analysis showed that, among 12 genes listed by 7 ( RASSF1A , CCND2 SPINT2 RUNX3 GSTP1 APC CFTR...
A bootstrap technique for nearest neighbor classifier design is proposed. Our primary interest in designing a small training sample size situations. Conventional bootstrapping techniques the samples with replacement. On other hand, our generates by locally combining original samples. The designed on and tested test independent of performance proposed demonstrated three artificial data sets one real set. Experimental results show that outperforms conventional k-NN classifiers as well edited...
SUMMARY The global incidence of nonalcoholic steatohepatitis (NASH) is increasing and current mammalian models NASH are imperfect. We have developed a model in the ricefish medaka (Oryzias latipes), which based on feeding fish high-fat diet (HFD). Medaka that fed HFD (HFD-medaka) exhibited hyperlipidemia hyperglycemia, histological examination liver revealed ballooning degeneration. expression lipogenic genes (SREBP-1c, FAS ACC1) was increased, whereas lipolytic (PPARA CPT1) decreased. With...
Hyperspectral imaging (HSI) is a new technology that obtains spectroscopic information and renders it in image form. This study examined the difference spectral reflectance (SR) of gastric tumors normal mucosa recorded with hyperspectral camera equipped HSI attempted to determine specific wavelength useful for diagnosis cancer. A total 104 removed by endoscopic submucosal dissection from 96 patients at Yamaguchi University Hospital were using camera. We determined optimal cut-off value...
Application of machine vision is expected for efficiency and objectivity inspection in various fields. Automation visual asphalt pavement surface images also expected, but it difficult because unexpected objects, non-uniform illumination irregularities the surface. Many conventional approaches are based on state-of-the-arts. However, there a problem that application conditions these limited. In this article, we proposed new method state-of-the-art learning crack detection from images. The...
Abstract The outcome of patients with hepatocellular carcinoma (HCC) remains poor because the high frequency intrahepatic recurrence (IHR), particularly early IHR within 1 year hepatectomy. To search for genes involved in IHR, we performed DNA microarray analysis a training set 33 HCCs and selected 46 linked to from approximately 6,000 by means supervised learning method. Gene selection was validated false discovery rate 0.37%. included many immune response‐related genes, which were all...
Many clinical trials of peptide vaccines have been conducted. However, these provided benefits in only a small fraction patients. The purpose the present study was to explore microRNAs (miRNAs) as novel predictive biomarkers for efficacy vaccine treatment against colorectal cancer. First, we carried out microarray analysis pretreatment cancer tissues phase I study, which alone were given. Candidate miRNAs selected by comparison better prognosis group with poorer group. Next, conducted II...
Constipation is characterized by a variety of bowel symptoms such as difficulty passing stool, hard and feeling incomplete evacuation. The multifactorial causes constipation limit the clinical efficacy current conventional treatments that use single drug acts through only one pathway. To complement shortcomings Western medical model provide complete holistic approach, herbal medicines capable targeting multiple organs cellular sites may be used. In Japan, many herbs combinations have...
We previously reported the effectiveness of product tumor number and size (NxS factor) for prognosis hepatocellular carcinoma (HCC) in patients following hepatectomy. The present study aimed to propose a new score based on NxS factor predict HCC recurrence A total 406 who underwent hepatectomy at Osaka University Graduate School Medicine were retrospectively analyzed develop score. Among clinicopathological factors, including factor, marker subset that achieved best performance prediction...
Cancer stem cells ( CSC s) are thought to play important roles in cancer malignancy. Previously, we successfully induced sphere stem‐like CSLC from several cell lines and observed the property of chemoresistance. In present study, examined metastatic potential these s. Sphere were a human hepatoma line SK ‐ HEP ‐1) unique medium containing neural survival factor‐1. Splenic injection into immune‐deficient mice was used assess hematogenous liver metastasis. Transcriptomic strand‐specific RNA...
Abstract Although the physiological actions of many herbs are gradually being elucidated at molecular level, it remains unclear how individual components contribute to their biological activities. In present study, antiproliferative activity Coptidis rhizoma , a medicinal herb, and major component berberine was investigated in 8 human pancreatic cancer cell lines. Gene expression patterns associated with sensitivities each agent were analyzed oligonucleotide arrays that comprised...