A5028649129- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Immune Cell Function and Interaction
- Immune cells in cancer
- Burn Injury Management and Outcomes
- Wound Healing and Treatments
- Immune responses and vaccinations
- Respiratory Support and Mechanisms
- Thermal Regulation in Medicine
- Prostate Cancer Treatment and Research
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Cardiac Arrest and Resuscitation
- Tissue Engineering and Regenerative Medicine
- Anesthesia and Pain Management
- S100 Proteins and Annexins
- Antimicrobial Peptides and Activities
- Pancreatitis Pathology and Treatment
- COVID-19 Impact on Reproduction
- Adrenal Hormones and Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Nitric Oxide and Endothelin Effects
East Tennessee State University
2019-2025
Vanderbilt University Medical Center
2016-2025
Vanderbilt University
2013-2025
Shriners Hospitals for Children - Galveston
2003-2018
Medical University of South Carolina
2017
The University of Texas Medical Branch at Galveston
2005-2014
Bipar
2008-2010
Central Texas Veterans Health Care System
2010
Shriners Hospitals for Children
2002-2009
National Institute of General Medical Sciences
2008
A defining pathophysiologic feature of sepsis is profound apoptosis-induced death and depletion CD4+ CD8+ T cells. Interleukin-7 (IL-7) an antiapoptotic common γ-chain cytokine that essential for lymphocyte proliferation survival. Clinical trials IL-7 in over 390 oncologic lymphopenic patients showed was safe, invariably increased counts, improved immunity.We conducted a prospective, randomized, double-blind, placebo-controlled trial recombinant human (CYT107) with septic shock severe...
Preoperative anxiety and emergence delirium in children continue to be common even with midazolam premedication. Midazolam is unpleasant tasting a flavored vehicle as result, patient acceptance sometimes poor. As an alternative, we evaluated dexmedetomidine administered intranasally. Dexmedetomidine alpha-2 adrenergic agonist tasteless, odorless, painless when by this route. Alpha-2 agonists produce sedation, facilitate parental separation, improve conditions for induction of general...
Interleukin (IL)-18 is an important effector of innate and adaptive immunity, but its expression must also be tightly regulated because it can potentiate lethal systemic inflammation death. Healthy septic human neonates demonstrate elevated serum concentrations IL-18 compared with adults. Thus, we determined the contribution to lethality mechanism in a murine model neonatal sepsis. We find that IL-18-null mice are highly protected from polymicrobial sepsis, whereas replenishing increased...
Bacterial infections are a common and deadly threat to vulnerable patients. Alternative strategies fight infection needed. β-Glucan, an immunomodulator derived from the fungal cell wall, provokes resistance by inducing trained immunity, phenomenon that persists for weeks months. Given durability of it is unclear which leukocyte populations sustain this effect. Macrophages have life span surpasses duration immunity. Thus, we sought define contribution differentiated macrophages Our results...
Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies protect patients with weak immune responses urgently needed. Employing trained immunity, whereby innate leukocytes undergo reprogramming upon exposure a microbial product and respond more robustly subsequent infection, is promising approach. Previously, we demonstrated that the TLR4 agonist monophosphoryl lipid A (MPLA) induces immunity confers broad resistance infection. signals through...
ABSTRACT Gamma interferon (IFN-γ) is an important mediator of endotoxin (lipopolysaccharide [LPS])-induced immune responses. However, the specific cell types that produce IFN-γ in response to LPS and cellular factors regulate LPS-induced production have not been fully determined. The present studies were undertaken characterize populations after challenge spleens mice determine regulatory modulate IFN-γ. Our show levels splenic mRNA protein peak at 6 8 h, respectively, systemic challenge....
No AccessJournal of Urology1 Jan 1990Differential Cytokeratin Expression in Normal, Hyperplastic and Malignant Epithelial Cells From Human Prostate Edward R. Sherwood, Lori A. Berg, Nancy J. Mitchell, John E. McNeal, James M. Kozlowski, Chung Lee SherwoodEdward Sherwood More articles by this author , BergLori Berg MitchellNancy Mitchell McNealJohn McNeal KozlowskiJames Kozlowski LeeChung View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39903-2AboutPDF ToolsAdd to...
ABSTRACT Monophosphoryl lipid A (MPLA) is a Toll-like receptor 4 (TLR4) agonist that currently used as vaccine adjuvant in humans. In this study, we evaluated the effect of MPLA treatment on innate immune response to systemic bacterial infections mice. Mice treated with after burn injury showed improved survival and less local dissemination bacteria model Pseudomonas aeruginosa wound infection. Prophylactic significantly enhanced clearance at site infection reduced despite causing...
IL-15 is currently undergoing clinical trials to assess its efficacy for treatment of advanced cancers. The combination with soluble IL-15Rα generates a complex termed superagonist (IL-15 SA) that possesses greater biological activity than alone. SA considered an attractive antitumor and antiviral agent because ability selectively expand NK memory CD8(+) T (mCD8(+) T) lymphocytes. However, the adverse consequences have not been defined. In this study, effect on physiologic immunologic...
The goal of the current study was to investigate effect aging on development endothelial dysfunction in a murine model sepsis, and compare it with genetic deficiency isoform nitric oxide synthase (eNOS).Cecal ligation puncture (CLP) used induce sepsis mice. Survival rates were monitored plasma indices organ function measured. Ex vivo studies included measurement vascular thoracic aortic rings, assessment oxidative stress/cellular injury various organs mitochondrial isolated liver...