Sheqouia A. Nauta
A5018462586- Immune responses and vaccinations
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Lysosomal Storage Disorders Research
- Cerebrovascular and Carotid Artery Diseases
- Atherosclerosis and Cardiovascular Diseases
- Cellular transport and secretion
- Immune Cell Function and Interaction
- Sphingolipid Metabolism and Signaling
- Extracellular vesicles in disease
- Advanced Biosensing Techniques and Applications
Icahn School of Medicine at Mount Sinai
2020-2024
Macrophages play a central role in the pathogenesis of atherosclerosis. The inflammatory properties these cells are dictated by their metabolism, which mechanistic target rapamycin (mTOR) signaling pathway is key regulator. Using myeloid cell-specific nanobiologics apolipoprotein E-deficient (Apoe-/-) mice, we found that targeting mTOR and ribosomal protein S6 kinase-1 (S6K1) pathways rapidly diminished plaque macrophages' activity. By investigating transcriptome modifications, identified...
Abstract Regulating innate immunity is an emerging approach to improve cancer immunotherapy. Such regulation requires engaging myeloid cells by delivering immunomodulatory compounds hematopoietic organs, including the spleen. Here we present a polymersome-based nanocarrier with splenic avidity and propensity for red pulp cell uptake. We characterized in vivo behaviour of four chemically identical yet topologically different polymersomes positron emission tomography imaging innovative flow...
Immunotherapies controlling the adaptive immune system are firmly established, but regulating innate remains much less explored. The intrinsic interactions between nanoparticles and phagocytic myeloid cells make these materials especially suited for engaging system. However, developing nanotherapeutics is an elaborate process. Here, we demonstrate a modular approach that facilitates efficiently incorporating broad variety of drugs in nanobiologic platform. Using microfluidic formulation...