A5079445792- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Lipoproteins and Cardiovascular Health
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Systemic Lupus Erythematosus Research
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- COVID-19 diagnosis using AI
- Rheumatoid Arthritis Research and Therapies
- Venous Thromboembolism Diagnosis and Management
- Clostridium difficile and Clostridium perfringens research
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 and healthcare impacts
- Advanced MRI Techniques and Applications
- Cancer, Lipids, and Metabolism
- Autoimmune and Inflammatory Disorders Research
- MRI in cancer diagnosis
- Gastrointestinal motility and disorders
- Nosocomial Infections in ICU
- Ultrasound in Clinical Applications
- Nutritional Studies and Diet
- Pneumonia and Respiratory Infections
University of Amsterdam
2013-2022
Amsterdam University Medical Centers
2020-2022
Institute for Atherosclerosis Research
2020
Amsterdam UMC Location University of Amsterdam
2013-2018
University Medical Center Utrecht
2012
Coronavirus disease 2019 (COVID-19) can lead to systemic coagulation activation and thrombotic complications.To investigate the incidence of objectively confirmed venous thromboembolism (VTE) in hospitalized patients with COVID-19.Single-center cohort study 198 COVID-19.Seventy-five (38%) were admitted intensive care unit (ICU). At time data collection, 16 (8%) still 19% had died. During a median follow-up 7 days (IQR, 3-13), 39 (20%) diagnosed VTE whom 25 (13%) symptomatic VTE, despite...
Intestinal microbiota have been found to be linked cardiovascular disease via conversion of the dietary compounds choline and carnitine atherogenic metabolite TMAO (trimethylamine-N-oxide). Specifically, a vegan diet was associated with decreased plasma levels nearly absent production on challenge. We performed double-blind randomized controlled pilot study in which 20 male metabolic syndrome patients were single lean vegan-donor or autologous fecal transplantation. At baseline 2 weeks...
Purpose To prospectively compare the diagnostic accuracy of controlled attenuation parameter (CAP) obtained with transient elastography and proton density fat fraction (PDFF) magnetic resonance (MR) spectroscopy results liver biopsy in a cohort adult patients suspected having nonalcoholic fatty disease (NAFLD). Materials Methods The institutional review board approved this study. Informed consent was from all patients. authors evaluated 55 NAFLD (40 men, 15 women). Patients had median age...
Individuals with nonalcoholic fatty liver disease (NAFLD) have an altered gut microbiota composition. Moreover, hepatic DNA methylation may be in the state of NAFLD. Using a fecal transplantation (FMT) intervention, we aimed to investigate whether change composition relates assessed plasma metabolite profiles by FMT relate changes methylation. Twenty-one individuals NAFLD underwent three 8-weekly vegan allogenic donor (n = 10) or autologous 11) FMTs. We obtained from paired biopsies study...
Reverse cholesterol transport (RCT) contributes to the anti-atherogenic effects of HDL. Patients with orphan disease, familial hypoalphalipoproteinemia (FHA), are characterized by decreased tissue removal and an increased atherogenic burden. We performed open-label uncontrolled proof-of-concept study evaluate effect infusions a human apoA-I-containing HDL-mimetic particle (CER-001) on RCT arterial vessel wall in FHA. Subjects received 20 CER-001 (8 mg/kg) during 6 months. Efficacy was...
Background and aimsInfusion of high-density lipoprotein (HDL) mimetics aimed at reducing atherosclerotic burden has led to equivocal results, which may relate in part the inability HDL adequately reach lesions humans. This study evaluated delivery recombinant human apolipoprotein A-I (apoA-I) containing mimetic CER-001 carotid plaques patients.MethodsCER-001 was radiolabeled with long-lived positron emitter zirconium-89 (89Zr) enable emission tomography computed (PET/CT) imaging. Eight...
Coronavirus disease 2019 (COVID-19) can lead to systemic coagulation activation and thrombotic complications. We investigated the incidence of objectively confirmed venous thromboembolism (VTE) in 198 hospitalized patients with COVID-19 a single-center cohort study. Seventy-four (37%) were admitted intensive care unit (ICU). At time data collection, 58 (29%) still 14% had died. During median follow-up 5 days (IQR, 3-9), 33 (17%) diagnosed VTE whom 22 (11%) symptomatic VTE, despite routine...
Background Clinicians need to rapidly and reliably diagnose coronavirus disease 2019 (COVID-19) for proper risk stratification, isolation strategies, treatment decisions. Purpose To assess the real-life performance of radiologist emergency department chest CT interpretation diagnosing COVID-19 during acute phase pandemic, using Reporting Data System (CO-RADS). Materials Methods This retrospective multicenter study included consecutive patients who presented departments in six medical centers...
To (a) study the optimal timing and dosing for ultrasmall superparamagnetic iron oxide particle (USPIO)-enhanced magnetic resonance (MR) imaging of liver in nonalcoholic fatty disease, (b) evaluate whether hepatic USPIO uptake is decreased steatohepatitis (NASH), (c) diagnostic accuracy USPIO-enhanced MR to distinguish between NASH simple steatosis.This prospective was approved by local institutional review board, informed consent obtained from all patients. Quantitative R2* performed at...
Background and aimsInflammation in atherosclerotic plaques is an important determinant of plaque vulnerability, can be detected non-invasively using ultra-small superparamagnetic iron-oxide (USPIO) enhanced MRI. The aims the current study were: 1) to determine whether ferumoxytol used for USPIO-MRI plaques, 2) establish a protocol quantitative carotid artery ferumoxytol, 3) relation between USPIO uptake burden 18F-fluorodeoxyglucose (FDG) (measured by 18F-FDG PET/CT scan) plaques.MethodsIn 9...
Purpose A novel three‐dimensional (3D) T 1 and 2 mapping protocol for the carotid artery is presented. Methods 3D black‐blood imaging sequence was adapted allowing using multiple flip angles echo time (TE) preparation times. B performed to correct spatially varying deviations from nominal angle. The optimized simulations phantom experiments. In vivo scans were on six healthy volunteers in two sessions, a patient with advanced atherosclerosis. Compensation motion achieved by registration of...
Increasing numbers of patients (up to 40 %) with rheumatoid arthritis (RA) achieve remission, yet it remains be elucidated whether this also normalizes their cardiovascular risk. Short-term treatment TNF inhibitors lowers arterial wall inflammation, but not levels healthy controls. We investigated RA in long-term remission are characterized by normalized inflammatory activity the and if is dependent on type medication used (TNF-inhibitor versus nonbiological disease-modifying antirheumatic...
The quantification of vessel wall morphology and plaque burden requires segmentation, which is generally performed by manual delineations. purpose our work to develop evaluate a new 3D model-based approach for carotid artery segmentation from dual-sequence MRI.The proposed method segments the lumen outer surfaces including bifurcation region fitting subdivision surface constructed hierarchical-tree model image data. In particular, hybrid combines deformable with boundary classification was...
Purpose To study the interscan reproducibility of manual versus automated segmentation carotid artery plaque components, and agreement between both methods, in high lower quality MRI scans. Methods 24 patients with 30–70% stenosis were planned for 3T MRI, followed by a rescan within 1 month. A multicontrast protocol (T1w,T2w, PDw TOF sequences) was used. After co-registration delineation lumen outer wall, components (lipid-rich necrotic cores (LRNC) calcifications) performed manually...
Introduction: Clinicians have been struggling with the optimal diagnostic approach of patients suspected COVID-19. We evaluated added value chest CT over RT-PCR alone. Methods: Consecutive adult COVID-19 presenting to emergency department (Academic Medical Center, Amsterdam University Centers, Netherlands) from March 16th April were retrospectively included if they required hospital admission and underwent testing for SARS-CoV-2 infection. The CO-RADS classification was used assess...