A5030455874- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac and Coronary Surgery Techniques
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Aortic aneurysm repair treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Effects of Exercise
- Cardiovascular Health and Disease Prevention
- Mechanical Circulatory Support Devices
- Health Systems, Economic Evaluations, Quality of Life
- Peripheral Artery Disease Management
- Advanced X-ray and CT Imaging
- Diabetes Treatment and Management
- Hemodynamic Monitoring and Therapy
- Radiation Dose and Imaging
- Atrial Fibrillation Management and Outcomes
- Intensive Care Unit Cognitive Disorders
- Adipokines, Inflammation, and Metabolic Diseases
University Medical Center Utrecht
2016-2025
Utrecht University
2013-2025
Hypertension Institute
2024
SMART Reading
2024
Heidelberg University
2012-2017
University Hospital Heidelberg
2012-2017
Institute of Cardiology
2016-2017
Erasmus MC
2015-2016
Isala
2001-2015
University Medical Center
2014-2015
Coronary artery disease (CAD) is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive. This can be modified lifestyle adjustments, pharmacological therapies, and invasive interventions designed to achieve stabilization regression. The have long, stable periods but also become unstable at any time, typically due an acute atherothrombotic event caused rupture erosion. However, chronic, most often...
Background The use of cardiopulmonary bypass during coronary artery surgery (CABG) has been associated with substantial morbidity. recent introduction cardiac stabilizers facilitates CABG without (off-pump CABG), but it is unknown whether outcome after off-pump similar to that for the on-pump procedure. Methods and Results In a multicenter trial, 281 patients (mean age 61 years, SD 9 years) were randomly assigned or CABG. In-hospital results quality life 1 month are presented. Cardiac was...
The performance of coronary bypass surgery without cardiopulmonary ("off pump") may reduce perioperative morbidity and costs, but it is uncertain whether the outcome similar to that involving use ("on pump").In a multicenter, randomized trial, we randomly assigned 139 patients with predominantly single- or double-vessel disease on-pump 142 off-pump surgery. Cardiac cost effectiveness were determined one year after uncertainty surrounding cost-effectiveness ratio (cost differences per...
Background— To identify patients at risk for postoperative myocardial injury and death, measuring cardiac troponin routinely after noncardiac surgery has been suggested. Such monitoring was implemented in our hospital. The aim of this study to determine the predictive value injury, as measured by elevation, on 30-day mortality surgery. Methods Results— This observational, single-center cohort included 2232 consecutive intermediate- high-risk aged ≥60 years who underwent 2011. Troponin first...
Abstract Background Type 2 diabetes is a condition associated with state of low-grade inflammation caused by adipose tissue dysfunction and insulin resistance. High sensitive-CRP (hs-CRP) marker for systemic higher plasma levels have been cardiovascular events in various populations. The aim the current study to evaluate relation between hs-CRP incident all-cause mortality high-risk type patients. Methods Prospective cohort 1679 patients included Second Manifestations ARTerial disease...
Physical activity and exercise training are associated with a lower risk for coronary events. However, cross-sectional studies in middle-aged older male athletes revealed increased artery calcification (CAC) atherosclerotic plaques, which were related to the amount intensity of lifelong exercise. We examined longitudinal relationship between characteristics atherosclerosis. Middle-aged men from MARC-1 (Measuring Athlete's Risk Cardiovascular Events 1) study invited follow-up MARC-2 2) study....
ContextConventional coronary artery bypass graft surgery with use of cardiopulmonary (on-pump CABG) is associated excellent long-term cardiac outcomes but also a high incidence cognitive decline. The effect avoiding (off-pump on and unknown.ObjectiveTo compare the off-pump CABG on-pump outcomes.Design, Setting, ParticipantsThe Octopus Study, multicenter randomized controlled trial conducted in Netherlands, which enrolled 281 low-risk patients between 1998 2000. Five years after their...
Abstract Background Percutaneous treatment of coronary bifurcation lesions remains hampered by suboptimal results, mainly in the side branch (SB), even with use drug‐eluting stents (DES). Paclitaxel balloons (DEB) could provide an attractive alternative to treat bifurcations combination a provisional T‐stenting technique order minimize SB restenosis. We compared angiographic and clinical outcomes DEB plus bare‐metal stent (BMS) versus BMS paclitaxel DES. Methods In this randomized,...
Abstract Background: Cardiac surgery can be complicated by postoperative cognitive decline (POCD), which is characterized impaired memory function and intellectual ability. The systemic inflammatory response that induced major cardiopulmonary bypass may play an important role in the etiology of POCD. Prophylactic corticosteroids to attenuate therefore reduce risk authors investigated effect intraoperative high-dose dexamethasone on incidence POCD at 1 month 12 months after cardiac surgery....
To evaluate the role of routine troponin surveillance in patients undergoing major noncardiac surgery, unblinded screening with cardiac consultation per protocol was implemented at a tertiary care center. In this study, we evaluated 1-year mortality, causes death, and consequences protocol.This observational cohort included 3224 ≥60 years old surgery. Troponin I measured routinely on first 3 postoperative days. Myocardial injury defined as >0.06 μg/L. Regression analysis used to determine...
OBJECTIVE Methylglyoxal (MGO) is a reactive dicarbonyl compound and potential key player in diabetic cardiovascular disease (CVD). Whether plasma MGO levels are associated with CVD type 2 diabetes unknown. RESEARCH DESIGN AND METHODS We included 1,003 individuals (mean ± SD age 59.1 10.5 years, 69.3% male, 61.6% prior CVD) from the Second Manifestations of ARTerial cohort (SMART). measured two other dicarbonyls (glyoxal [GO] 3-deoxyglucosone [3-DG]) at baseline mass spectrometry. Median...
Purpose The Utrecht Cardiovascular Cohort–Second Manifestations of Arterial Disease (UCC-SMART) Study is an ongoing prospective single-centre cohort study with the aim to assess important determinants and prognosis cardiovascular disease progression. This article provides update rationale, design, included patients, measurements findings from start in 1996 date. Participants UCC-SMART includes patients aged 18–90 years referred University Medical Center Utrecht, Netherlands, for management...
Background The radiodensity of epicardial adipose tissue may provide information on cardiovascular risk in addition to volume. aim this study was quantify the relation between factors and patients at high disease. Design This a cross-sectional 140 Methods Patients from Secondary Manifestations ARTerial disease (SMART) cohort were invited undergo cardiac computed tomography angiography. (in Hounsfield units; HU) volume cm3) quantified semi-automatically. Multivariable linear regression used...
Most exercise-related cardiac arrests in men aged ≥45 years are due to coronary artery disease (CAD). The current sports medical evaluation (SME) of middle-aged sportsmen includes history, physical examination and resting exercise electrocardiography (ECG). We investigated the added value low-dose computed tomography (CCT) - both non-contrast CT for calcium scoring (CACS) contrast-enhanced angiography (CCTA) order detect occult CAD asymptomatic recreational without known cardiovascular...
Background Health-related quality of life (HRQOL) reflects the general well-being individuals. In patients with coronary artery disease (CAD), HRQOL is compromised. Female CAD have been reported to lower HRQOL. this study, we investigate gender differences in and associations patient characteristics angiography (CAG). Methods We cross-sectionally analysed from Utrecht Coronary Biobank undergoing CAG. All filled an questionnaire (RAND-36 EuroQoL) on inclusion. RAND-36 EuroQoL measures were...
The objective of this present study is to determine whether high ankle brachial index (ABI) as compared with ABIs within reference limits associated an increased incidence cardiovascular disease (CVD) events and all-cause mortality in a high-risk population association the same for patients without diabetes mellitus or prevalent CVD.Seven thousand five hundred thirty-eight ABI>0.9 either CVD risk were selected from Second Manifestations Arterial Disease (SMART) study. Three thirty-six...