A5045091636- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Acute Myocardial Infarction Research
- Aortic Disease and Treatment Approaches
- Tendon Structure and Treatment
- Spaceflight effects on biology
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Tissue Engineering and Regenerative Medicine
- Medical and Biological Ozone Research
- Spinal Cord Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Pulmonary Hypertension Research and Treatments
- Transplantation: Methods and Outcomes
- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Aortic Thrombus and Embolism
- Bee Products Chemical Analysis
- Trauma Management and Diagnosis
- Cardiac Ischemia and Reperfusion
- Viral Infections and Immunology Research
Innsbruck Medical University
2016-2025
Universität Innsbruck
2016-2025
Austrian Cluster for Tissue Regeneration
2019
As many current approaches for heart regeneration exert unfavourable side effects, the induction of endogenous repair mechanisms in ischaemic disease is particular interest. Recently, exosomes carrying angiogenic miRNAs have been described to improve function. However, it remains challenging stimulate specific release reparative myocardium. In present study, we sought test hypothesis that physical stimulus shock wave therapy (SWT) causes exosomes. We aimed substantiate pro-angiogenic impact...
Abstract Background and Aims In chronic ischaemic heart failure, revascularisation strategies control symptoms but are less effective in improving left ventricular ejection fraction (LVEF). The aim of this trial is to investigate the safety cardiac shockwave therapy (SWT) as a novel treatment option its efficacy increasing function by inducing angiogenesis regeneration hibernating myocardium. Methods single-blind, parallel-group, sham-controlled (cardiac for ischemic CAST-HF; NCT03859466)...
Calcific aortic valve disease (CAVD) is characterized by a phenotypic switch of valvular interstitial cells to bone-forming cells. Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition at the interface between innate immunity and tissue repair. Type I interferons (IFNs) not only crucial for an adequate antiviral response but also implicated in bone formation. We hypothesized that accumulation endogenous TLR3 ligands leaflets may promote generation osteoblast-like...
Abstract OBJECTIVES Barlow’s disease is a specific sub-form of mitral valve (MV) disease, characterized by diffuse excessive tissue and multi segment prolapse. The anterolateral mini-thoracotomy represents the standard access for MV regurgitation in many centres. It still remains unclear which surgical technique provides best results. Therefore, aim this study was to compare operative safety mid-term outcomes after (i) isolated annuloplasty, (ii) use additional artificial chordae or (iii)...
Background Mechanical stimulation of acute ischemic myocardium by shock wave therapy ( SWT ) is known to improve cardiac function induction angiogenesis. However, in chronic heart failure poorly understood. We aimed study whether mechanical upon improves angiogenesis and postnatal vasculogenesis dissect underlying mechanisms. Methods Results was applied a mouse model myocardial ischemia. To effects on vasculogenesis, wild-type mice received bone marrow transplantation from green fluorescence...
Recent advances in machine learning provide new possibilities to process and analyse observational patient data predict outcomes. In this paper, we introduce a processing pipeline for cardiogenic shock (CS) prediction from the MIMIC III database of intensive cardiac care unit patients with acute coronary syndrome. The ability identify high-risk could possibly allow taking pre-emptive measures thus prevent development CS. We mainly focus on techniques imputation missing by generating...
Abstract Aims Cardiac shockwave therapy (SWT) improves left ventricular (LV) function in patients with ischaemic cardiomyopathy. Shockwave activates Toll-like receptor 3 (TLR3), a receptor-inducing chromatin remodelling and nuclear reprogramming of cardiac cells. We hypothesized that mechanical activation TLR3 facilitates fibroblasts towards endothelial cells restoring myocardial perfusion function. Methods results Human were treated by stimulation via SWT or agonist Poly(I:C) the presence...
Spinal cord injury (SCI) remains a devastating condition with poor prognosis and very limited treatment options. Affected patients are severely restricted in their daily activities. Shock wave therapy (SWT) has shown potent regenerative properties bone fractures, wounds, ischemic myocardium via activation of the innate immune receptor TLR3. Here, we report on efficacy SWT for regeneration SCI. improved motor function decreased lesion size WT but not Tlr3–/– mice inhibition neuronal...
Abstract Shock wave treatment ( SWT ) was shown to induce regeneration of ischaemic myocardium via Toll‐like receptor 3 TLR 3). The antimicrobial peptide LL 37 gets released by mechanical stress and is known form complexes with nucleic acids thus activating receptors. We suggested that in the acute setting prevents from development heart failure RNA /protein release. Myocardial infarction mice induced followed subsequent . Heart function assessed 4 weeks later transthoracic echocardiography...
Chronic non-healing wounds pose a global health challenge. Under optimized conditions, skin heal by the formation of scar tissue. However, deregulated cell activation leads to persistent inflammation and granulation tissue, type premature tissue without epithelialization. Regenerative cells from wound periphery contribute healing process, but little is known about their cellular fate in an inflammatory, macrophage-dominated microenvironment.We examined CD45-/CD31-/CD34+ preadipocytes CD68+...
The impact of sex-differences on the release cardiac biomarkers after coronary artery bypass grafting (CABG) remains unknown. aim our study was to (1) investigate in biomarker CABG and (2) determine sex-specific thresholds for high-sensitivity troponin (hs-cTn) creatine kinase-myocardial band (CK-MB) associated with 30-day major adverse cardiovascular events (MACE) mortality.
Abstract OBJECTIVES Ischaemia and subsequent reperfusion during heart transplantation inevitably result in donor organ injury. Toll-like receptor (TLR)-3 is a pattern recognition activated by viral endogenous RNA released injured cells. We hypothesized that ischaemia/reperfusion injury (IRI) leads to release with TLR3 activation transplanted hearts. METHODS Human endothelial cells were subjected IRI treated agonist polyinosinic–polycytidylic acid or TLR3/double-stranded complex inhibitor....
Across Europe there are significant variations in the fundamental structure and content of cardiothoracic surgery (CTS) training programmes. Previous efforts have been made to introduce a Unified European Training System, which outlined fundamentals ideal programme supported paradigm shift from an apprenticeship competency-based model. This article's goal was define key structural, administrative executive details such lay foundations for standardization surgical across Europe.The...
Abstract OBJECTIVES Mechanical strain plays a major role in the development of aortic calcification. We hypothesized that (i) valvular calcifications are most pronounced at localizations subjected to highest mechanical and (ii) calcification patterns different patients with bicuspid tricuspid valves. METHODS Multislice computed tomography scans 101 severe stenosis were analysed using 3-dimensional post-processing software quantify valves (n = 51) 50) after matching. RESULTS Bicuspid...
Coronary artery diseases (CAD) remains a severe socio-economic burden in the Western world. obstruction and subsequent myocardial ischemia result progressive replacement of contractile myocardium with dysfunctional, fibrotic scar tissue. Post-infarctional remodeling is causal for concomitant decline left-ventricular function fatal syndrome heart failure. Available neurohumoral treatment strategies aim at improvement symptoms. Despite extensive research, therapeutic options regeneration,...
The prognosis of COVID-19 patients with cardiac involvement is unfavorable and it remains unknown which are at risk. virus enters cells via its receptor angiotensin-converting enzyme 2 (ACE2). Myocardial ACE2 expression increased in structural heart disease (SHD). We, therefore, aimed to analyze correlations between SARS-CoV-2 manifestation.The clinical course was assessed a prospective cohort 152 patients. primary endpoints consisted hospitalization survival. Cardiac tissue 23 autopsy cases...
Abstract Shockwave therapy (SWT) represents a promising regenerative treatment option for patients with ischemic cardiomyopathy. Although no side-effects have been described upon SWT, potential cellular damage at therapeutic energies has not addressed so far. In this work, we aimed to define range shock wave application myocardial regeneration. We could demonstrate that SWT does induce beneath energy levels of 0.27 mJ/mm 2 total flux density. Endothelial cell proliferation, angiogenic gene...
The need to ration medical equipment and interventions during the coronavirus disease 2019 pandemic translated an ever-lengthening wait list for surgical care. Retrospective analysis of lockdowns is high importance learn from current situation future pandemics. This monocentric study assessed impact lockdown periods on cardiac surgery cases outcomes.The single-centre cross-sectional descriptive observational was conducted investigate first period following post-lockdown in comparison same...