A5080172025- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Hydraulic and Pneumatic Systems
- Organ Donation and Transplantation
- Pancreatitis Pathology and Treatment
- Vehicle Noise and Vibration Control
- Hepatocellular Carcinoma Treatment and Prognosis
- Tribology and Lubrication Engineering
- Gallbladder and Bile Duct Disorders
- Mechanical Failure Analysis and Simulation
- Mechanical Engineering and Vibrations Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Vehicle Dynamics and Control Systems
- Gastric Cancer Management and Outcomes
- Acoustic Wave Phenomena Research
- Colorectal Cancer Surgical Treatments
- Control Systems in Engineering
- Wound Healing and Treatments
- Music Technology and Sound Studies
- Viral-associated cancers and disorders
- Pharmacological Effects and Toxicity Studies
Innsbruck Medical University
2016-2025
Universität Innsbruck
2016-2025
Ascension Via Christi
2020-2025
Wichita State University
2013-2024
University of Kansas
2013-2024
Klinik für Frauenheilkunde
2021
Anstalt für Verbrennungskraftmaschinen List (Austria)
2007-2020
Virtual Vehicle (Austria)
2019
Technische Universität Berlin
2013-2015
University of Basel
2015
Normothermic machine perfusion (NMP) has emerged as an innovative organ preservation technique. Developing understanding for the donor immune cell composition and its dynamic changes during NMP is essential. We aimed a comprehensive characterization of (sub)populations, trafficking cytokine release liver NMP. Single-cell transcriptome profiling human livers prior to, after transplantation shows abundance CXC chemokine receptor 1+/2+ (CXCR1+/CXCR2+) neutrophils, which significantly decreased...
Background. Normothermic machine perfusion (NMP) bears the potential for significant prolongation of liver preservation before transplantation. Although safety and feasibility have been recently published, no data are available describing challenges establishing NMP programs outside clinical studies. We herein present our experience propose a multidisciplinary approach in routine. Methods. In February 2018, was introduced routine use marginal organs, logistic challenges, complex recipients...
To report outcomes from routine clinical practice of liver transplantation (LT) following normothermic machine perfusion (NLMP) and compare to LT after static cold storage (SCS). NLMP is emerging as a in has recently received renewed attention, however outside trials are lacking. All adult between February 2018 January 2023 were included. Comprehensive viability assessment was applied during NLMP. Outcomes compared SCS recipients, well benchmark non-benchmark cases. Of the 332 included, 174...
Given the susceptibility of organs to ischaemic injury, alternative preservation methods static cold storage (SCS), such as normothermic machine perfusion (NMP) are emerging. The aim this study was perform a comparison between NMP and SCS in liver transplantation with particular attention bile duct lesions.The outcomes 59 consecutive NMP-preserved donor livers were compared 1 : propensity score-matched fashion control livers. Postoperative complications, patient survival, graft survival...
Background Simultaneous pancreas-kidney (SPK) transplantation is widely accepted as an optimal therapeutic option for patients with type 1 diabetes mellitus (T1DM) and end-stage renal disease, but the indication 2 (T2DM) still controversially discussed. Methods Twenty-one T2DM recipients of a first combined graft performed at our center during 9-year period were retrospectively analyzed regard to demographic characteristics; cardiovascular risk factors; surgical, immunological, infectious...
Normothermic machine perfusion (NMP) has become a clinically established tool to preserve livers in near-physiological environment. However, little is known about the predictive value of perfusate parameters toward outcomes after transplantation.Fifty-five consecutive NMP between 2018 and 2019 were included. All perfused on OrganOx metra device according an institutional protocol. Transplant data collected prospectively.Forty-five transplanted NMP. Five stem from donors circulatory death 31...
Normothermic liver machine perfusion (NLMP) is advancing the field of transplantation (LT). Beyond improved preservation and organ assessment, NLMP helps to increase utilization. We herein address feasibility merit in split (SLT) postpone second graft following day.
Management of benign liver tumours (BLT) is still object discussion. Uncertainty exists about patient selection, details management, indications for surgical intervention and potential surgery-related complications. The up-to-date strategies management the most common solid are recapitulated in this article. In addition, recommendations concerning practical issues presented. Available data from peer-reviewed publications associated with major controversies treatment BLT were selected through...
Accurate burn depth estimation remains one of the foundations optimal care. The method by which is determined has traditionally been clinical examination alone. This continues to hold true in United States, despite a plethora literature supporting use more accurate modalities such as laser Doppler imaging (LDI). LDI widespread centers Kingdom and around world. Thus, reason for lack U.S. elusive. A survey center directors was conducted assess their current practices attitudes with regard at...
A comparative analysis of inflammation between solid organs following donor brain death (BD) is still lacking and the detailed influence BD accelerating ischaemia–reperfusion injury (IRI) post-transplantation remains to be addressed. Applying a murine model BD, we demonstrated that 4 h after were characterized by distinct inflammatory expression patterns. For instance, lipocalin 2 (LCN2), marker acute kidney injury, was selectively induced in livers but not kidneys. further resulted...
Abstract Introduction Evidence-based practice recognizes cutaneokinematics as a key concept in development of the rehabilitation therapy plan care for burn patients. Without sufficient treatment, patients are at risk scar contracture and deconditioning, among other complications. The first phase this quality improvement project focused on staff knowledge confidence applying cutaneokinematics. Methods A before-after design was used to compare therapist prior after education initial use newly...
Kidneys from brain-death small pediatric donors ≤2 years are still classified as marginal organs. Herein, we analyse the outcomes following en-bloc kidney transplantation (EBKT) into adult recipients compared to standard criteria donor transplant (SKTs). A retrospective single center analysis of a prospectively collected and auditable database identified six EBKTs 75 SKTs between January 2015 June 2017. Propensity score matching minimized selection bias. After median follow-up 74 months,...
Although percutaneous biopsies are considered to be the gold standard in diagnosing pancreas graft rejection, they not performed routinely because of their association with severe complications. On other hand, correct diagnosis rejection is essential but may difficult cases enteric drainage, particularly patients a transplant alone or after kidney transplant.Pancreas recipients who underwent enteroscopy between May 2005 and September 2009 were included this retrospective analysis. Biopsies...
Background: Through efficacy and improved safety, multiport laparoscopic sleeve gastrectomy (LAPS-G) has emerged as an important broadly available treatment option for people with severe complex obesity. Because a single-incision (SILS-G) would be less invasive, we applied this novel surgical technique selected number of patients enrolled into our minimally invasive bariatric program. Subjects Methods: A retrospective review prospectively collected data from 80 morbidly obese who qualified...
Despite clear advances in decreasing postoperative mortality below 4% after pancreatic resections experienced centres, specific morbidity according to standardized definitions still remains high. While some recent multicentre studies have reported on complications surgery Austria, detailed outcome data from single high-volume centres over longer time-periods are scarce. This study provides an in-depth picture of patient characteristics, indications, and Austrian tertiary referral centre. All...
Background. Sarcopenia is an established risk factor predicting survival in chronically ill and trauma patients. We herein examine the assessment clinical implication of sarcopenia liver transplantation (LT). Methods. Computerized tomography scans from 172 patients waitlisted for LT were analyzed by applying 6 morphometric muscle scores, including 2 density indices (psoas [PD] skeletal [SMD]) 4 scores based on area (total psoas area, index, index). Results. The prevalence our cohort ranged...
Transplantation activity during the first wave of coronavirus disease 2019 (COVID-19) pandemic was severely affected worldwide. This retrospective analysis aimed to assess impact COVID-19 on organ donations and transplantations in Eurotransplant region 12 mo pandemic. Specifically, we compared donor transplantation numbers both waves determine whether transplant systems adapted this new reality.All reported from March 1, 2015, February 28, 2021, were collected International Foundation...
Normothermic machine perfusion (NMP) allows for ex vivo viability and functional assessment prior to liver transplantation (LT). Hyperspectral imaging represents a suitable, non-invasive method evaluate tissue morphology organ during NMP. Liver allografts were subjected NMP LT. Serial image acquisition of oxygen saturation levels (StO2), hemoglobin (THI), near-infrared (NIR) water indices (TWI) through hyperspectral was performed static cold storage, at 1h, 6h, 12h the end The readouts...