A5049188873- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Xenotransplantation and immune response
- Neurological Complications and Syndromes
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Angiogenesis and VEGF in Cancer
- Chemokine receptors and signaling
- Hematopoietic Stem Cell Transplantation
- Iron Metabolism and Disorders
- T-cell and B-cell Immunology
- Material Properties and Applications
- Adenosine and Purinergic Signaling
- Liver Disease and Transplantation
- Biomedical Ethics and Regulation
- Hemoglobinopathies and Related Disorders
- Viral Infections and Immunology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Organ and Tissue Transplantation Research
- Alcohol Consumption and Health Effects
- IL-33, ST2, and ILC Pathways
Innsbruck Medical University
2012-2017
Universität Innsbruck
2014-2017
Charité - Universitätsmedizin Berlin
2014-2017
A comparative analysis of inflammation between solid organs following donor brain death (BD) is still lacking and the detailed influence BD accelerating ischaemia–reperfusion injury (IRI) post-transplantation remains to be addressed. Applying a murine model BD, we demonstrated that 4 h after were characterized by distinct inflammatory expression patterns. For instance, lipocalin 2 (LCN2), marker acute kidney injury, was selectively induced in livers but not kidneys. further resulted...
Abstract In enterovirus‐induced cardiomyopathy, information regarding the detailed impact of natural killer ( NK ) cells on outcome disease is limited. We therefore hypothesized that and certain cell receptors determine different coxsackievirus B3 CVB3 myocarditis. Here, we demonstrate in murine models resistance to chronic myocarditis immunocompetent C57BL /6 mice characterized by significantly more mature CD11b high cells, presence NKG2D enhanced ‐dependent cytotoxicity compared...
Nonalcoholic steatohepatitis (NASH) is an increasingly prevalent indication for liver transplantation (LT) across the world. The relative outcomes following are poorly described in this cohort. We aimed to analyze incidence and outcome of LT NASH as compared with other indications.This a retrospective analysis 513 patients who underwent deceased-donor, adult between 2002 2012 recorded at Medical University Innsbruck, Austria.The prevalence cirrhosis was 12.7% (65/513). Patient survival...
It has already been shown that neutralization of the activating NK cell receptor NKG2D in combination with co-stimulation blockade prolongs graft survival vascularized transplants. In order to clarify underlying cellular mechanisms, we transplanted complete MHC-disparate BALB/c-derived cardiac grafts into C57BL/6 wildtypes or mice deficient for (Klrk1-/- ). Although median was 8 days both recipient groups, detected at day 5 posttransplantation significantly greater intragraft frequencies...
Brain death (BD) has been associated with an immunological priming of donor organs and is thought to exacerbate ischemia reperfusion injury (IRI). Recently, we showed that the essential nitric oxide synthase co-factor tetrahydrobiopterin (BH4) abrogates IRI following experimental pancreas transplantation. We therefore studied effects BD in a murine model syngeneic transplantation tested therapeutic potential BH4 treatment. Compared sham-operated controls, resulted intragraft inflammation...
Brain death (BD) and its complex pathophysiological changes have been shown to significantly influence allograft quality leading impaired transplant survival. However, detailed molecular cellular information regarding inflammation associated with BD is missing. In order study the mechanisms of more comprehensively, we developed a model in mouse. C57BL/6 mice underwent induction were followed for 4 hours under continuous ventilation. Ventilated (sham group SH) as well naive served controls...
Although it has been shown that Natural Killer (NK) cells influence allograft survival, little is known about the detailed involvement of their receptors. To elucidate functional importance during acute rejection, we used BALB/c mice as donors and NKp46-/GFP, NKG2D-/- Ly49kd (C57BL/6 background) recipients in a heterotopic HTX model. Wildtype C57BL/6 served controls. Animals were either sacrificed at day 5 (d5) or graft rejection (dRx) for analysis (n=5/group/time point). survival revealed...
Background: Brain death (BD) has been shown to immunologically prime grafts in part by aggravating ischemia reperfusion injury (IRI). Herein we assessed the effects of BD on IRI an experimental setting furthermore therapeutic potential tetrahydrobiopterin (BH4), essential NOS-cofactor was tested. Methods and Materials: Pancreas transplantation performed using C57BL/6-mice. Animals underwent induction were followed for 3h. Experimental groups included: non-treated BD-donors, BD-donors treated...
Rabbit antithymocyte globulin (rATG) is widely used as induction agent in solid organ transplantation. Beside depletion of circulating lymphocytes there a growing body evidence suggesting that rATG may also play pivotal role modulating the immune system. As blood endothelial cells (CECs) and hematopoietic progenitor (CPCs) represent two minute fractions mononuclear are thought to important roles tissue vascularisation, study both cell types currently suggested surrogate markers for numerous...
Introduction: Acute kidney injury (ARI) and acute renal failure (ARF) are major complications following liver transplantation (LT) leading up to chronic end-stage disease. The etiology of post-LT impairment is multi-factorial but it suggested that e.g. during ischemia initial insults provoke morphological functional changes within the vascular endothelium tubular epithelium. Methods: As has been demonstrated, ischemic ARF can occur in absence classical T cell function Natural Killer (NK)...