A5017189713- MicroRNA in disease regulation
- Circular RNAs in diseases
- Coronary Interventions and Diagnostics
- Angiogenesis and VEGF in Cancer
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Long-Term Effects of COVID-19
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Blood Pressure and Hypertension Studies
- Cardiac Fibrosis and Remodeling
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Arrhythmias and Treatments
- Protease and Inhibitor Mechanisms
- Adenosine and Purinergic Signaling
- Telomeres, Telomerase, and Senescence
- Nuclear Receptors and Signaling
- Infective Endocarditis Diagnosis and Management
- Mesenchymal stem cell research
- Cerebrovascular and Carotid Artery Diseases
University Hospital in Halle
2019-2025
Martin Luther University Halle-Wittenberg
2019-2025
Deutsches Herzzentrum München
2022-2025
Medizinische Hochschule Hannover
2004-2025
Chonnam National University Hwasun Hospital
2023
Kemerovo State University
2023
Kyungpook National University
2023
Luther University
2020-2022
Justus-Liebig-Universität Gießen
2003-2017
Universitätsklinikum Gießen und Marburg
2002-2015
Upon vascular injury, locally controlled haemostasis prevents life-threatening blood loss and ensures wound healing. Intracellular material derived from damaged cells at these sites will become exposed to components could contribute coagulation pathological thrombus formation. So far, the functional mechanistic consequences of this concept are not understood. Here, we present in vivo vitro evidence that different forms eukaryotic prokaryotic RNA serve as promoters coagulation. Extracellular...
Abstract Inflammation is a hallmark and potent driver of pathological vascular remodelling in atherosclerosis. However, current anti-inflammatory therapeutic strategies have shown mixed results. As an alternative perspective on the conundrum chronic inflammation emerging evidence points towards small subset senescent cells as critical player central node driving Senescent belonging to various cell types are dominant source large array pro-inflammatory cytokines additional plaque...
MicroRNA (miR)-92a is an important regulator of endothelial proliferation and angiogenesis after ischaemia, but the effects miR-92a on re-endothelialization neointimal lesion formation vascular injury remain elusive. We tested lowering levels using specific locked nucleic acid (LNA)-based antimiRs as well endothelial-specific knock out wire-induced femoral artery in mice.MiR-92a was significantly up-regulated lesions following injury. Pre-miR-92a overexpression resulted repression direct...
In the REPAIR-AMI trial, intracoronary infusion of bone marrow-derived cells (BMCs) was associated with a significantly greater recovery contractile function in patients acute myocardial infarction (AMI) at 4-month follow-up than placebo infusion. The current analysis investigates clinical outcome and predictors event-free survival 5 years.In multicentre, placebo-controlled, double-blind 204 received BMCs (n = 101) or 103) into infarct vessel 3-7 days following successful percutaneous...
Limited progress has been made in the management of cardiogenic shock (CS). Morbidity and mortality refractory CS remain high. The effects mechanical circulatory support (MCS) are promising, although many aspects elusive. We evaluated efficacy safety early combined MCS (Impella microaxial pump + venoarterial extracorporeal membrane oxygenation [VA-ECMO]) aimed to determine factors for decision-making MCS.We analyzed 69 consecutive patients with from our registry requiring MCS. In 12 cases,...
Post-acute sequelae of COVID-19 (PASC) are long-term consequences SARS-CoV-2 infection that can substantially impair the quality life. Underlying mechanisms ranging from persistent viruses to innate and adaptive immune dysregulation have been discussed. Here, we profiled plasma 181 individuals cohort study for digital health research in Germany (DigiHero), including after mild moderate with or without PASC uninfected controls. We focused on soluble factors related monocyte/macrophage biology...
Mechanotransduction represents an integral part of vascular homeostasis and contributes to lesion formation. Previously, we demonstrated a mechanosensitive activation phosphoinositide 3-kinase (PI3-K)/protein kinase B (Akt) resulting in p27 Kip1 transcriptional downregulation cell cycle entry smooth muscle cells (VSMC). In this study, further elucidated the signaling from outside-in toward PI3-K/Akt vitro vivo model elevated tensile force. When VSMC were subjected cyclic stretch (0.5 Hz at...
We hypothesized that apolipoprotein E (apoE)(-/-)/low-density lipoprotein (LDL)(-/-) double knockout mice might develop vasa vasorum (VV) in association with advanced lesion formation.Aortas from apoE(-/-)/LDL(-/-) aged 16, 18, 20, or 80 weeks were infused situ Microfil, harvested, and scanned micro-computed tomography (CT). characterized plaque volume CT "density" as well VV luminal along the aorta using Analyze 6.0 software. Results complemented by a detailed histological classification...
The chemokine receptor CXCR4 is a promising target for molecular imaging of CXCR4+ cell types, e.g. inflammatory cells, in cardiovascular diseases. We speculated that specific ligand, [68Ga]pentixafor, along with novel techniques motion correction, would facilitate the vivo characterization expression small culprit and nonculprit coronary atherosclerotic lesions after acute myocardial infarction by motion-corrected targeted PET/CT.CXCR4 was analysed ex separately obtained arterial wall...
Intensive Care Resources are heavily utilized during the COVID-19 pandemic. However, risk stratification and prediction of SARS-CoV-2 patient clinical outcomes upon ICU admission remain inadequate. This study aimed to develop a machine learning model, based on retrospective & prospective data, stratify predict survival outcomes.A Germany-wide electronic registry was established pseudonymously collect admission, therapeutic discharge information patients retrospectively prospectively. Machine...
Background In the connected world, although societies are not directly involved in a military conflict, they exposed to media reports of violence. Aims We assessed effects such exposures on mental health Germany during conflict Ukraine. Method used German population-based cohort for digital research, DigiHero, launching survey eighth day Russo-Ukrainian war. Of 27 509 participants from general population, 19 444 (70.7%) responded within 17 days. measured and fear impact war compared with...
Renal sympathetic denervation (RDN) has been shown to lower arterial blood pressure both in the presence and absence of antihypertensive medication an observation period up 3 years. However, long-term results beyond years are scarcely reported.We performed a follow-up on patients who were previously enrolled local renal registry underwent radiofrequency RDN with Symplicity Flex® system between 2011 2014. The assessed evaluate their function by performing 24-hour ambulatory measurement...
BACKGROUND: Intermittent fasting has shown positive effects on numerous cardiovascular risk factors. The INTERFAST-MI trial (Intermittent Fasting in Myocardial Infarction) been designed to study the of intermittent cardiac function after STEM (ST-segment–elevation myocardial infarction) and feasibility future multicenter trials. METHODS: was a prospective, randomized, controlled, nonblinded, single-center investigator-initiated trial. From October 1, 2020, July 15, 2022, 48 patients were...
Vascular smooth muscle cells (VSMCs) constitute the major cellular component of vessel tunica media. VSMC proliferation is a key feature in developing vessels and pathological states such as atherosclerosis restenosis. Transforming growth factor (TGF)-β regulator VSMCs, but its effect on apoptosis are controversial. Here, we characterized TGF-β effects basal-, serum-, platelet-derived factor-BB-induced primary mouse proliferation. led to potent inhibition VSMCs isolated from normal aortae...
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