A5004315051- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Peptidase Inhibition and Analysis
- Medical Imaging Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- S100 Proteins and Annexins
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
- Cardiovascular Disease and Adiposity
- Cardiomyopathy and Myosin Studies
- Chemokine receptors and signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Signaling Pathways in Disease
- Protease and Inhibitor Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Prostate Cancer Treatment and Research
- Cardiac Ischemia and Reperfusion
- GDF15 and Related Biomarkers
Medizinische Hochschule Hannover
2016-2025
Leiden University Medical Center
2023
University of Michigan
2023
University Hospital of Wales
2023
Mallinckrodt (United States)
2023
Deaconess Hospital
2023
Beth Israel Deaconess Medical Center
2023
Universität Hamburg
2016
Technical University of Munich
2016
University Medical Center Hamburg-Eppendorf
2016
<b>Background and Rationale:</b> After acute myocardial infarction (AMI), fibroblast activation protein (FAP) upregulation exceeds the infarct region. We sought further insights into physiologic relevance by correlating FAP-targeted PET with tissue characteristics from cardiac magnetic resonance (CMR) functional outcome. <b>Methods:</b> Thirty-five patients underwent CMR, perfusion SPECT, <sup>68</sup>Ga-FAPI-46 PET/CT within 11 days after AMI. Infarct size was determined SPECT comparison to...
The CXC-motif chemokine receptor 4 (CXCR4) represents a promising target for molecular imaging of different CXCR4-positive cell types in cardiovascular diseases such as atherosclerosis and arterial wall injury. aim this study was to assess the prevalence, pattern, clinical correlates accumulation <sup>68</sup>Ga-pentixafor, specific CXCR4 ligand PET. <b>Methods:</b> data 51 patients who underwent <sup>68</sup>Ga-pentixafor PET/CT noncardiovascular indications were retrospectively analyzed....
The benefit of the β1-adrenergic receptor (β1-AR) agonist dobutamine for treatment acute heart failure in peripartum cardiomyopathy (PPCM) is controversial. Cardiac STAT3 expression reduced PPCM patients. Mice carrying a cardiomyocyte-restricted deletion (CKO) develop PPCM. We hypothesized that STAT3-dependent signalling networks may influence response to β-AR patients and analysed this hypothesis CKO mice.Follow-up analyses 27 with severe (left ventricular ejection fraction ≤25%) revealed...
The chemokine receptor CXCR4 is a promising target for molecular imaging of CXCR4+ cell types, e.g. inflammatory cells, in cardiovascular diseases. We speculated that specific ligand, [68Ga]pentixafor, along with novel techniques motion correction, would facilitate the vivo characterization expression small culprit and nonculprit coronary atherosclerotic lesions after acute myocardial infarction by motion-corrected targeted PET/CT.CXCR4 was analysed ex separately obtained arterial wall...
Abstract Aims Balance between inflammatory and reparative leucocytes allows optimal healing after myocardial infarction (MI). Interindividual heterogeneity evokes variable functional outcome complicating targeted therapy. We aimed to characterize infarct chemokine CXC-motif receptor 4 (CXCR4) expression using positron emission tomography (PET) establish its relationship cardiac outcome. tested whether image-guided early CXCR4 directed therapy attenuates chronic dysfunction. Methods results...
Acute tissue inflammation after myocardial infarction influences healing and remodeling has been identified as a target for novel therapies.Molecular imaging holds promise guidance of such therapies.The amino acid 11 C-methionine is clinically approved agent which thought to accumulate in macrophages, but not healthy myocytes.We assessed the suitability positron emission tomography (PET) with post-MI inflammation, from cell mouse man.Uptake assays demonstrated 7-fold higher uptake by...
We recently demonstrated in a clinical trial the ability of new protocol, IQ SPECT, to acquire myocardial perfusion imaging (MPI) studies quarter time (12 s/view) standard with preserved diagnostic accuracy. now aim establish lower limit radioactivity that can be administered patients and minimum acquisition SPECT MPI using an while preserving <b>Methods:</b> An anthropomorphic cardiac phantom was used rest scans simulated vivo distribution <sup>99m</sup>Tc-tetrofosmin at full dose (740 MBq)...
Abstract Background Diabetes mellitus is strongly associated with cardiovascular dysfunction, derived in part from impairment of sympathetic nervous system signaling. Glucose, insulin, and non-esterified fatty acids are potent stimulants activity norepinephrine (NE) release. We hypothesized that sustained hyperglycemia the high fat diet-fed streptozotocin (STZ) rat model insulin resistance would exhibit progressive dysfunction parallel deteriorating myocardial systolic and/or diastolic...
High-energy resolution and sensitivity of novel cadmium-zinc-telluride (CZT) detector equipped SPECT systems facilitate simultaneous imaging multiple isotopes may enhance the detection molecular/cellular signals. This refine endocarditis. study was designed to determine feasibility diagnostic accuracy inflammation with 111In-labeled white blood cells (WBCs) myocardial perfusion 99mTc-sestamibi, for localization WBCs relative valve plane in suspected A dedicated cardiac CZT camera (Discovery...
Purpose The aims of this study were to gain mechanistic insights into prostate cancer biology using dynamic imaging and evaluate the usefulness multiple time-point 68Ga–prostate-specific membrane antigen (PSMA) I&T PET/CT for assessment primary before prostatectomy. Methods Twenty patients with underwent 68Ga-PSMA PET protocol consisted early pelvic imaging, followed by static scans at 60 180 minutes postinjection (p.i.). SUVs, time-activity curves, quantitative analysis based on a 2-tissue...
Using multimodal imaging, we investigated the extent and functional correlates of myocardial fibroblast activation in patients with aortic stenosis (AS) scheduled for transcatheter valve replacement (TAVR). AS may cause fibrosis, which is associated disease progression limit response to TAVR. Novel radiopharmaceuticals identify upregulation protein (FAP) as a cellular substrate cardiac profibrotic activity. <b>Methods:</b> Twenty-three underwent <sup>68</sup>Ga-FAP inhibitor 46...
Advanced cancer induces fundamental changes in metabolism and promotes cardiac atrophy heart failure. We discovered systemic insulin deficiency cachectic patients. Similarly, mice with advanced B16F10 melanoma (B16F10-TM) or colon 26 carcinoma (C26-TM) displayed decreased associated marked atrophy, metabolic impairment, function. C26 tumors decrease via high glucose consumption, lowering pancreatic production producing insulin-degrading enzyme. As tumor cells consume an insulin-independent...
Abstract Purpose Myocardial infarction (MI) triggers a local inflammatory response which orchestrates cardiac repair and contributes to concurrent neuroinflammation. Angiotensin-converting enzyme (ACE) inhibitor therapy not only attenuates remodeling by interfering with the neurohumoral system, but also influences acute leukocyte mobilization from hematopoietic reservoirs. Here, we seek dissect anti-inflammatory anti-remodeling contributions of ACE inhibitors benefit heart brain outcomes...
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Background: Myocardial infarction (MI) evokes an organized remodeling process characterized by the activation and transdifferentiation of quiescent cardiac fibroblasts to generate a stable collagen rich scar.Early fibroblast may be amenable targeted therapy, but is challenging identify in vivo.We aimed non-invasively image active fibrosis targeting protein (FAP) expressed activated (myo)fibroblasts, using novel positron emission tomography (PET) radioligand [ 68 Ga]MHLL1 after acute...