A5039730806- Cardiac Imaging and Diagnostics
- Receptor Mechanisms and Signaling
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Neurotransmitter Receptor Influence on Behavior
- Phosphodiesterase function and regulation
- Renin-Angiotensin System Studies
- Cholinesterase and Neurodegenerative Diseases
- Cardiac electrophysiology and arrhythmias
- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Synthesis and Biological Evaluation
- Prostate Cancer Treatment and Research
- Neurological disorders and treatments
- Tissue Engineering and Regenerative Medicine
- Nitric Oxide and Endothelin Effects
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Chemical Reactions and Isotopes
- Heart Rate Variability and Autonomic Control
- Pulmonary Hypertension Research and Treatments
Université de Montréal
2015-2025
Centre Hospitalier de l’Université de Montréal
2018-2023
Providence Health Care
2021
University of Ottawa
2008-2017
University of Toronto
1994-2016
Harborview Medical Center
2016
University of Washington
2016
St. Michael's Hospital
2016
University Health Network
2016
Hamilton Health Sciences
2016
<sup>18</sup>F-FDG PET may assist decision making in ischemic cardiomyopathy. The and Recovery Following Revascularization (PARR 2) trial demonstrated a trend toward beneficial outcomes with PET-assisted management. substudy of PARR 2 that we call Ottawa-FIVE, described here, was post hoc analysis to determine the benefit center experience, ready access <sup>18</sup>F-FDG, integration clinical teams. <b>Methods:</b> Included were patients left ventricular dysfunction suspected coronary...
Whether viability imaging can impact long-term patient outcomes is uncertain. The PARR-2 study (Positron Emission Tomography and Recovery Following Revascularization) showed a nonsignificant trend toward improved at 1 year using an F-18-fluorodeoxyglucose positron emission tomography (PET)-assisted strategy in patients with suspected ischemic cardiomyopathy. When adhered to PET recommendations, outcome benefit was observed. Long-term of imaging-assisted management have not previously been...
Abstract Background Diabetes mellitus is strongly associated with cardiovascular dysfunction, derived in part from impairment of sympathetic nervous system signaling. Glucose, insulin, and non-esterified fatty acids are potent stimulants activity norepinephrine (NE) release. We hypothesized that sustained hyperglycemia the high fat diet-fed streptozotocin (STZ) rat model insulin resistance would exhibit progressive dysfunction parallel deteriorating myocardial systolic and/or diastolic...
Abstract: The pharmacokinetics of [ 11 CJtetrabenazine, a high‐affinity radioligand for the monoamine vesicular transporter, were determined in living human brain using vivo imaging by positron emission tomography (PET). radiotracer showed high uptake and rapid washout from all regions with relatively slower clearance highest concentrations transporters (striatum), resulting clear differential visualization these structures at short intervals after injection (10–20 min). As first PET study...
Background— Collagen delivery matrices have been reported to improve the results of cell therapy, but knowledge their mechanisms action is limited. To evaluate whether a collagen matrix improves early engraftment posttransplantation, 2-[ 18 F]fluoro-2-deoxy- d -glucose ( F-FDG) was used label transplanted circulating progenitor cells (CPCs) and track them in vivo with positron-emission tomography. Methods Results— Efficiency F-FDG labeling CPC-concentration dependent r =0.61, P <0.001)...
A noninvasive and repeatable method for assessing mouse myocardial glucose uptake with <sup>18</sup>F-FDG PET Patlak kinetic analysis was systematically assessed using the vena cava image–derived blood input function (IDIF). <b>Methods:</b> Contrast CT computer modeling used to determine recovery coefficient. Vena IDIF (<i>n</i> = 7) compared left ventricular cavity IDIF, liver activity measured ex vivo at 60 min. The test–retest repeatability 9) of influx constant K<sub>i</sub> 10–40 min...
Background People living with HIV (PLWH) have a higher risk of myocardial infarction. Coronary atherosclerotic plaque CT characterization helps to predict cardiovascular risk. Purpose To measure characteristics coronary in PLWH without known disease and healthy volunteers HIV. Materials Methods In this prospective study, noncontrast (all participants, n = 265) was used for artery calcium (CAC) scoring asymptomatic HIV, disease, from 2012 2019. At angiography (n 233), prevalence, frequency,...
(11)C-meta-Hydroxyephedrine (HED) is used in cardiac PET as an index of norepinephrine (NE) reuptake transporter (NET) density and synaptic NE levels. Whereas uptake well documented, tracer retention other tissues with rich noradrenergic innervation unclear. Dysfunctional sympathetic nervous system (SNS) function extracardiac metabolic storage (i.e., adipose tissue skeletal muscle) endocrine organs contributes to several disorders. The aim this study was determine the potential HED brown...
Cell therapy is expected to restore perfusion and improve function in the ischemic/infarcted myocardium; however, biological mechanisms local effects of transplanted cells remain unclear. To assess cell fate vivo, hexadecyl-4-[(18)F]fluorobenzoate ((18)F-HFB) labeling was evaluated for tracking human circulating progenitor (CPCs) with positron emission tomography (PET) compared commonly used 2-[(18)F]fluoro-2-deoxy-d-glucose ((18)F-FDG) method a rat myocardial infarction model. CPCs were...