A5101834207- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Viral Infections and Immunology Research
- Pulmonary Hypertension Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- Tissue Engineering and Regenerative Medicine
- Cardiac electrophysiology and arrhythmias
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Cardiac Health and Mental Health
- Cardiac Arrest and Resuscitation
- Chemotherapy-induced cardiotoxicity and mitigation
- Blood Pressure and Hypertension Studies
- Heart rate and cardiovascular health
- Cardiac Arrhythmias and Treatments
University of Saskatchewan
2016-2025
Saskatoon Medical Imaging
2018-2021
Royal University Hospital
2018-2020
Instituto Dante Pazzanese de Cardiologia
2019
Clinical Research Institute
2019
University of Ottawa
2007-2016
University of British Columbia
2016
St. Michael's Hospital
2016
University Health Network
2016
University of Toronto
2016
Background— Oxidative stress may contribute to heart failure (HF) progression. Inhibiting xanthine oxidase in hyperuricemic HF patients improve outcomes. Methods and Results— We randomly assigned 253 with symptomatic HF, left ventricular ejection fraction ≤40%, serum uric acid levels ≥9.5 mg/dL receive allopurinol (target dose, 600 mg daily) or placebo a double-blind, multicenter trial. The primary composite end point at 24 weeks was based on survival, worsening patient global assessment....
<sup>18</sup>F-FDG PET may assist decision making in ischemic cardiomyopathy. The and Recovery Following Revascularization (PARR 2) trial demonstrated a trend toward beneficial outcomes with PET-assisted management. substudy of PARR 2 that we call Ottawa-FIVE, described here, was post hoc analysis to determine the benefit center experience, ready access <sup>18</sup>F-FDG, integration clinical teams. <b>Methods:</b> Included were patients left ventricular dysfunction suspected coronary...
Background— There remains limited insight into the pathophysiology and therapeutic advances directed at improving prognosis for patients with heart failure preserved ejection fraction (HFpEF). Recent studies have suggested a role coronary microvascular dysfunction in HFpEF. Rb-82 cardiac positron emission tomography imaging is noninvasive, quantitative approach to measuring myocardial flow reserve (MFR), surrogate marker vascular health. The aim of this study was determine whether...
Background— Cardiac allograft vasculopathy is a key prognostic determinant after heart transplant. Detection and risk stratification of patients with cardiac are problematic. Positron emission tomography using rubidium-82 allows quantification absolute myocardial blood flow may have utility for in this population. Methods Results— Patients history transplant undergoing dipyridamole positron were prospectively enrolled. Myocardial perfusion left ventricular ejection fraction recorded....
Whether viability imaging can impact long-term patient outcomes is uncertain. The PARR-2 study (Positron Emission Tomography and Recovery Following Revascularization) showed a nonsignificant trend toward improved at 1 year using an F-18-fluorodeoxyglucose positron emission tomography (PET)-assisted strategy in patients with suspected ischemic cardiomyopathy. When adhered to PET recommendations, outcome benefit was observed. Long-term of imaging-assisted management have not previously been...
Background— Left heart failure is characterized by alterations in metabolic substrate utilization, and modulation may be a future strategy the management of failure. Little known about cardiac metabolism right ventricle how it relates to other measures ventricular (RV) function. This study was designed measure glucose ventricle, as estimated [ 18 F]fluorodeoxyglucose (FDG) positron emission tomography imaging determine relation between RV function FDG uptake patients with Methods Results— A...
Abstract Background Ischemic heart disease (IHD) is the most common cause of failure (HF); however, role revascularization in these patients still unclear. Consensus on proper use cardiac imaging to help determine which candidates should be considered for has been hindered by absence clinical studies that objectively and prospectively compare prognostic information each test obtained using both standard advanced imaging. Methods/Design This paper describes design methods used Alternative...
Abstract Background Most people do not recognize symptoms of neurological and cardiac emergencies in a timely manner. This leads to delays hospital arrival reduced access therapies that can open arteries. We created smartphone app help patients families evaluate if may be high risk for stroke or heart attack (myocardial infarction, MI). The ECHAS (Emergency Call Heart Attack Stroke) guides users assess their through evidence-based questions test weakness one arm by evaluating finger-tapping...