A5037500425- Receptor Mechanisms and Signaling
- Complement system in diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cell Adhesion Molecules Research
- Medical and Biological Ozone Research
- Cytokine Signaling Pathways and Interactions
- Radiopharmaceutical Chemistry and Applications
- Chemical Synthesis and Analysis
- Asthma and respiratory diseases
- Long-Term Effects of COVID-19
- Blood Coagulation and Thrombosis Mechanisms
- Acute Ischemic Stroke Management
- Inhalation and Respiratory Drug Delivery
- Neuropeptides and Animal Physiology
- Viral Infectious Diseases and Gene Expression in Insects
- S100 Proteins and Annexins
- Adenosine and Purinergic Signaling
- Inflammation biomarkers and pathways
- Health Promotion and Cardiovascular Prevention
- COVID-19 Clinical Research Studies
- Air Quality and Health Impacts
- Dermatological and COVID-19 studies
- Mechanical Circulatory Support Devices
- Cancer, Stress, Anesthesia, and Immune Response
- Acute Myocardial Infarction Research
Klinikum Frankfurt Höchst
2018-2022
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
2006
Medizinische Hochschule Hannover
1997-2003
University of Wisconsin–Madison
2001
Background and Purpose: Stroke is reported as a consequence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in several reports. However, data are sparse regarding the details these patients multinational large scale. Methods: We conducted observational study on features consecutive ischemic stroke, intracranial hemorrhage, cerebral venous or sinus thrombosis among SARS-CoV-2–infected patients. further investigated risk vessel occlusion, stroke severity measured by...
The pathophysiological relevance of the complement split product C3a as a proinflammatory mediator is still ill defined. expression pattern human receptor (C3aR) can provide important clues for role this anaphylatoxin in inflammation. There strong evidence C3aR on basophils, and eosinophils, but additionally, only tumor cell lines leukemic or hepatic origin. It unclear whether neutrophils also express C3aR, need costimulus provided by eosinophils certain biological responses, lack respond to...
This report describes the first results of a rational hit-finding strategy to design novel small molecule antiinflammatory drugs targeting selectins, family three cellular adhesion molecules. Based on recent progress in understanding molecular interaction between selectins and their natural ligands as well clinical development synthetic antagonists like 1 (bimosiamose, TBC1269), this study was initiated discover selectin with improved pharmacological properties. Considering template...
Germfree transgenic epsilon 26 (Tgε26) mice, which express the full-length human CD3ε gene, have combined defects in natural killer (NK) cells and T were found to be extremely susceptible oroesophageal (palate, tongue, esophagus) gastric (cardia-antrum section) candidiasis. The gnotobiotic Tgε26 mice die, apparently from severe candidiasis, within 2–4 weeks after their alimentary tracts are colonized with Candida albicans. manifest resistance acute systemic candidiasis (intravenous...
The C3a receptor (C3aR) is expressed on most human peripheral blood leukocytes with the exception of resting lymphocytes, implying a much higher pathophysiological relevance anaphylatoxin as proinflammatory mediator than previously thought. response to this complement split product must be tightly regulated in situations sustained activation avoid deleterious effects caused by overactivated inflammatory cells. Receptor internalization, an important control mechanism described for G...
The goal of this study was to investigate whether prefeeding glycine reduces the immunoinflammatory response, degree distant organ injury (liver), and/or mortality rate in a two-hit model using intestinal ischemia/reperfusion and endotoxin (ET) challenge 6 h later rats. liver damage greatest at 24 after ET completely inhibited by glycine. early systemic increase proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) interleukin (IL) -6 as well secretion antiinflammatory cytokine...
Abstract The biological effects of the potent inflammatory mediator C5a, a complement split product, on human neutrophils and monocytes are limited by rapid internalization its specific receptor (C5aR, CD88). C terminus C5aR is phosphorylated after stimulation with C5a phorbol ester, this phosphorylation might lead to internalization. In context, we have studied 12‐myristate 13‐acetate (PMA), protein kinase inhibitor staurosporine, pertussis toxin rat basophilic RBL.2H3 cells stably...
We have analyzed the induction of receptor for anaphylatoxic peptide C3a (C3aR) by immunomodulator IFN-gamma, phorbol ester PMA, and dibutyryl cAMP (Bt2cAMP) in comparison with C5a (C5aR, CD88). For U937 cells, IFN-gamma Bt2cAMP up-regulated C3aR to same extent, whereas was 20-fold more effective C5aR induction. PMA increased expression C5aR, acted synergistically IFN-gamma. In contrast, did not increase specific 125I-hC3a binding, actually antagonized Two related human cell lines...
Abstract The anaphylatoxic peptide C3a is a pro‐inflammatory mediator generated during complement activation, whose specific G protein coupled receptor expressed on granulocytes, monocytes, mast cells, activated lymphocytes, and in the nervous tissue. We have RBL‐2H3 cell clones stably expressing mutants of human C3a‐receptor (C3aR) with combined alanine (Ala) substitutions ten C‐terminal serine (Ser) or threonine (Thr) residues, which may represent putative phosphorylation sites to...
Abstract Background Stroke is reported as a consequence of SARS-CoV-2 infection. However, there lack regarding comprehensive stroke phenotype and characteristics Methods We conducted multinational observational study on features consecutive acute ischemic (AIS), intracranial hemorrhage (ICH), cerebral venous or sinus thrombosis (CVST) among infected patients. further investigated the association demographics, clinical data, geographical regions, countries’ health expenditure AIS patients...
Abstract Background In Germany, 70,000–100,000 persons per year suffer from out-of-hospital cardiac arrest (OHCA). Despite medical progress, survival rates with good neurological outcome remain low. For many important clinical issues, no or only insufficient evidence randomised trials is available. Therefore, a systemic and standardised acquisition of the treatment course OHCA patients warranted. Study design The German Cardiac Arrest Registry (G-CAR) an observational, prospective,...
The selectin family of cell adhesion molecules (selectins) is comprised three structurally related calciumdependent carbohydrate binding proteins, E-, P-, and L-selectin. Located on the surface endothelial cells (E- Pselectin), platelets (P-selectin) leucocytes (L-selectin), selectins are vital importance for leukocyte recruitment accumulation in vasculature. Based unique architecture microvasculature lung, this task achieved by two different types mediated functions (i) tethering rolling...
Selectins, a family of adhesion molecules, play key role in the activation and extravasation leukocytes inflammatory diseases, like COPD. We investigated effect repeated inhalations pan-selectin antagonist Bimosiamose on ozone-induced airway inflammation healthy volunteers. In double-blind, placebo-controlled, randomised, cross-over study 4-days treatment with 10 mg bid inhaled by breath actuated nebuliser (AKITA2 APIXNEB®) cellular non-cellular composition induced sputum after inhalation...