Markus Friedrich
A5101460171- Insect Resistance and Genetics
- Insect symbiosis and bacterial influences
- Hemiptera Insect Studies
- Environmental DNA in Biodiversity Studies
- Freshwater macroinvertebrate diversity and ecology
- Subterranean biodiversity and taxonomy
- Phytoplasmas and Hemiptera pathogens
- Research on scale insects
- Insect-Plant Interactions and Control
- Nail Diseases and Treatments
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Fungal Infections and Studies
- Forest Insect Ecology and Management
- Cytokine Signaling Pathways and Interactions
- Cutaneous lymphoproliferative disorders research
- Trypanosoma species research and implications
- Insects and Parasite Interactions
- Psoriasis: Treatment and Pathogenesis
- Insect behavior and control techniques
- T-cell and B-cell Immunology
- Forest Ecology and Biodiversity Studies
- Plant and animal studies
- Insect Utilization and Effects
- RNA and protein synthesis mechanisms
Charité - Universitätsmedizin Berlin
2003-2021
Medical University of Graz
2021
Franklin University
2021
Wayne State University
2003-2020
Praxis
2013
Tsubaki (Germany)
2012
Charles University
2008
Humboldt-Universität zu Berlin
1997-2004
Klinik für Frauenheilkunde
2004
University Hospital Schleswig-Holstein
2004
The Functional Mockup Interface (FMI) is a tool independent standard for the exchange of dynamic models and Co-Simulation.The first version, FMI 1.0, was published in 2010.Already more than 30 tools support 1.0.In this paper an overview about upcoming version 2.0 given that combines formerly separated interfaces Model Exchange Co-Simulation one standard.Based on experience using many small details have been improved new features introduced to ease use increase performance especially larger...
Relatively little is known about the genomic basis and evolution of wood-feeding in beetles. We undertook genome sequencing annotation, gene expression assays, studies plant cell wall degrading enzymes, other functional comparative Asian longhorned beetle, Anoplophora glabripennis, a globally significant invasive species capable inflicting severe feeding damage on many important tree species. Complementary genes encoding enzymes involved digestion woody tissues or detoxification...
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between other include obligate microbial symbioses, viviparous reproduction, lactation. Here, we describe sequence annotation 366-megabase Glossina morsitans genome. Analysis genome 12,308 predicted protein-encoding genes led multiple discoveries, including chromosomal integrations...
Abstract Background Arthropods comprise the largest and most diverse phylum on Earth play vital roles in nearly every ecosystem. Their diversity stems part from variations a conserved body plan, resulting recorded adaptive changes genome. Dissection of genomic record sequence change enables broad questions regarding genome evolution to be addressed, even across hyper-diverse taxa within arthropods. Results Using 76 whole sequences representing 21 orders spanning more than 500 million years...
Abstract The bed bug, Cimex lectularius , has re-established itself as a ubiquitous human ectoparasite throughout much of the world during past two decades. This global resurgence is likely linked to increased international travel and commerce in addition widespread insecticide resistance. Analyses C. sequenced genome (650 Mb) 14,220 predicted protein-coding genes provide comprehensive representation that are traumatic insemination, reduced chemosensory repertoire related obligate...
The Mediterranean fruit fly (medfly), Ceratitis capitata, is a major destructive insect pest due to its broad host range, which includes hundreds of fruits and vegetables. It exhibits unique ability invade adapt ecological niches throughout tropical subtropical regions the world, though medfly infestations have been prevented controlled by sterile technique (SIT) as part integrated management programs (IPMs). genetic analysis manipulation has subject intensive study in an effort improve SIT...
Abstract Background The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology excellent experimental tractability molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids blood-feeding bed bugs, we present the genome sequence comparative analyses centered on milkweed bug Oncopeltus fasciatus , seed feeder family Lygaeidae. Results 926-Mb is well represented by current assembly official gene set....
Hyalella azteca is a cryptic species complex of epibenthic amphipods interest to ecotoxicology and evolutionary biology. It the primary crustacean used in North America for sediment toxicity testing an emerging model molecular ecotoxicology. To provide resources quality assessments studies, we sequenced, assembled, annotated genome H. U.S. Lab Strain. The completeness comparable with other ecotoxicological species. Through targeted investigation use gene expression data sets exposed...
Abstract Background Halyomorpha halys (Stål), the brown marmorated stink bug, is a highly invasive insect species due in part to its exceptionally high levels of polyphagy. This also nuisance overwintering human-made structures. It has caused significant agricultural losses recent years along Atlantic seaboard North America and continental Europe. Genomic resources will assist with determining molecular basis for this species’ feeding habitat traits, defining potential targets pest...
Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. distinguished from other Diptera by unique adaptations, including lactation birthing live young (obligate viviparity), a vertebrate blood-specific diet both sexes, obligate bacterial symbiosis. This work describes comparative analysis six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, austeni), Palpalis palpalis, fuscipes), Fusca...
Having conquered water surfaces worldwide, the semi-aquatic bugs occupy ponds, streams, lakes, mangroves, and even open oceans. The diversity of this group has inspired a range scientific studies from ecology evolution to developmental genetics hydrodynamics fluid locomotion. However, lack representative strider genome hinders our ability more thoroughly investigate molecular mechanisms underlying processes adaptation diversification within group. Here we report sequencing manual annotation...
Abstract Interleukin‐10 (IL‐10), originally identified as an inhibitor of pro‐inflammatory cytokine production, exerts multiple immunomodulatory functions. Its ability to inhibit a Th1 response has been used in clinical trials for the treatment inflammatory diseases including psoriasis. However, little is known about molecular mechanisms IL‐10 We aimed at identifying possiblemediators vitro monocytes by gene chip technology using Hu95a Affymetrix mRNA arrays with 12,000 genes. To prove...
ABSTRACT The systematic genetic analysis of Drosophila development has provided us with a deep insight into the molecular pathways early embryogenesis. question arises now whether these insights can serve as more general paradigm development, or they apply only to advanced insect orders. Though it is too give definitive answer this question, we suggest that there currently no firm reason believe mechanisms were elucidated in may not also other forms Thus, many genes involved pattern...
The molecular genetic dissection of Drosophila eye development led to the exciting discovery a surprisingly large panel genes and gene activities, which are functionally conserved across phyla. Little effort has yet been made towards pinpointing non-conserved functions in developing eye. This neglects fact that visual system is highly derived process. comparative analysis within insects can be expected enhance resolution accuracy between phyla comparisons development, reveal developmental...
Using genomic information from mosquito, red flour beetle, honeybee, mouse, and sea anemone, we have studied the molecular evolution of 91 Drosophila genes involved in eye primordium determination, retinal differentiation, phototransduction. Our results show that majority these gene sequences predate diversification endopterygote insects. However, all three functional groups contain a conspicuous fraction evolutionarily younger genes, which originated by tandem duplication lineage leading to...