A5081182542- Insect and Arachnid Ecology and Behavior
- Developmental Biology and Gene Regulation
- Insect Resistance and Genetics
- Neurobiology and Insect Physiology Research
- Animal Behavior and Reproduction
- Genomics and Phylogenetic Studies
- Animal Genetics and Reproduction
- Marine Ecology and Invasive Species
- Insect symbiosis and bacterial influences
- Physiological and biochemical adaptations
- Genetic diversity and population structure
- Hemiptera Insect Studies
- Plant and animal studies
- Insect Utilization and Effects
- Genetics, Aging, and Longevity in Model Organisms
- Invertebrate Immune Response Mechanisms
- RNA and protein synthesis mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Subterranean biodiversity and taxonomy
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Hippo pathway signaling and YAP/TAZ
- RNA Research and Splicing
- Insect-Plant Interactions and Control
- Marine Invertebrate Physiology and Ecology
Harvard University
2016-2025
Howard Hughes Medical Institute
2021-2025
Evolutionary Genomics (United States)
2025
Harvard University Press
2008-2024
Institut de Biologia Evolutiva
2020
University of Divinity
2018
American Institute of Biological Sciences
2012-2013
University of Cambridge
2003-2007
Centro de Biología Molecular Severo Ochoa
2001
Universidad Autónoma de Madrid
2001
The duplication of genes can occur through various mechanisms and is thought to make a major contribution the evolutionary diversification organisms. There increasing evidence for large-scale in some chelicerate lineages including two rounds whole genome (WGD) horseshoe crabs. To investigate this further, we sequenced analyzed common house spider Parasteatoda tepidariorum. We found pervasive both coding non-coding spider, clusters Hox genes. Analysis synteny conservation across P....
Myriapods (e.g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently insects. Myriapoda is only arthropod not represented by sequenced genome. We present an analysis genome centipede Strigamia maritima. It retains compact that has undergone less gene loss shuffling than previously arthropods, many orthologues genes conserved from bilaterian ancestor have been...
The amphipod crustacean Parhyale hawaiensis is a blossoming model system for studies of developmental mechanisms and more recently regeneration. We have sequenced the genome allowing annotation all key signaling pathways, transcription factors, non-coding RNAs that will enhance ongoing functional studies. member Malacostraca clade, which includes food crop species. analysed immunity related genes as an important comparative these species, where aquaculture problems increased farming has...
Abstract Background The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology excellent experimental tractability molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids blood-feeding bed bugs, we present the genome sequence comparative analyses centered on milkweed bug Oncopeltus fasciatus , seed feeder family Lygaeidae. Results 926-Mb is well represented by current assembly official gene set....
Abstract Background Most evolutionary developmental biology ("evo-devo") studies of emerging model organisms focus on small numbers candidate genes cloned individually using degenerate PCR. However, newly available sequencing technologies such as 454 pyrosequencing have recently begun to allow for massive gene discovery in animals without sequenced genomes. Within insects, although large volumes sequence data are holometabolous basally branching hemimetabolous insects typically suffer from...
SUMMARY Evolutionary developmental biology (evo‐devo) has undergone dramatic transformations since its emergence as a distinct discipline. This paper aims to highlight the scope, power, and future promise of evo‐devo transform unify diverse aspects biology. We articulate key questions at core eleven biological disciplines—from Evolution, Development, Paleontology, Neurobiology Cellular Molecular Biology, Quantitative Genetics, Human Diseases, Ecology, Agriculture Science Education, lastly,...
Most of our knowledge insect genomes comes from Holometabolous species, which undergo complete metamorphosis and have typically under 2 Gb with little signs DNA methylation. In contrast, Hemimetabolous insects the presumed ancestral process incomplete metamorphosis, larger high levels species Orthopteran order (grasshoppers crickets) some largest known genomes. What drives evolution these unusual genome sizes, remains unknown. Here we report sequencing, assembly annotation 1.66-Gb...
Summary Most bilaterians specify primordial germ cells (PGCs) during early embryogenesis using either inherited cytoplasmic line determinants (preformation) or induction of cell fate through signaling pathways (epigenesis). However, data from nonbilaterian animals suggest that ancestral metazoans may have specified very differently most extant bilaterians. Cnidarians and sponges been reported to generate continuously throughout reproductive life, but previous studies on members these basal...
A key focus of evolutionary developmental biology (evo-devo) in recent years has been to elucidate the evolution mechanisms as a means reconstructing hypothetical last common ancestors various clades. Prominent among such reconstructions have proposals nature mysterious "Urbilateria," originally defined ancestor extant Bilateria (protostomes and deuterostomes). Indeed, drawings this animal can now be found, well detailed information on genetics morphological processes that it used construct...
Abstract Background Arthropods are the most diverse animal phylum, but their genomic resources relatively few. While genome of branchiopod Daphnia pulex is now available, no other large-scale crustacean available for comparison. In particular, lacking tractable laboratory model development, amphipod Parhyale hawaiensis . Insight into shared and divergent characters genomes will facilitate interpretation future developmental, biomedical, ecological research using models. Results To generate a...
The evolutionary success of the largest animal phylum, Arthropoda, has been attributed to tagmatization, coordinated evolution adjacent metameres form morphologically and functionally distinct segmental regions called tagmata. Specification regional identity is regulated by Hox genes, which 10 are inferred be present in ancestor arthropods. With six different posterior identities divided into two tagmata, bauplan scorpions most heteronomous within Chelicerata. Expression domains anterior...
Parasteatoda tepidariorum is an increasingly popular model for the study of spider development and evolution more broadly. However, fully understanding regulation P. in comparison to other animals requires a genomic perspective. Although research on has provided major new insights, gene analysis date been limited candidate approaches. Furthermore, few available EST collections are based embryonic transcripts, which have not systematically annotated unlikely contain transcripts specific...
SUMMARY Among chelicerates, Hox gene expression has only been investigated in representatives of two arachnid orders to date: Acari (mites and ticks) Araneae (spiders). Limited data are available for the “primitive” orders, such as Scorpiones (scorpions) Opiliones (harvestmen). Here, we present first on harvestman Phalangium opilio . Ten genes this species were obtained from a de novo assembled developmental transcriptome using Illumina GAII platform. All 10 expressed characteristic Hox‐like...
Significance Many model organisms specify germ cells using maternally supplied germ-line determinants. In contrast, mice rely on embryonic cell–cell signaling to induce become cells. Molecular evidence for inductive specification had previously been provided only the mouse. Here we provide functional cell in an invertebrate, by showing that bone morphogenetic protein (BMP) signaling, which induces mouse specification, is required establishment of a cricket. BMP pathway knockdown causes...