A5033307441- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Sepsis Diagnosis and Treatment
- Platelet Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Acute Myocardial Infarction Research
- Respiratory Support and Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Cardiac electrophysiology and arrhythmias
- Heparin-Induced Thrombocytopenia and Thrombosis
- Hemodynamic Monitoring and Therapy
- Long-Term Effects of COVID-19
- Antimicrobial Resistance in Staphylococcus
- Hemophilia Treatment and Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Blood transfusion and management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Food Allergy and Anaphylaxis Research
Medical University of Vienna
2016-2025
Universitätszahnklinik Wien
2019-2022
University of Oxford
2021
Prince Charles Hospital
2021
Heinrich Heine University Düsseldorf
2018
Düsseldorf University Hospital
2018
Ludwig Boltzmann Institute of Osteology
2018
Hanusch Hospital
2018
Nicolaus Copernicus University
2018
Octapharma (Austria)
2011-2013
Background With the widespread use of direct oral anticoagulants (DOACs), there is an urgent need for a rapid assay to exclude clinically relevant plasma levels. Accurate and determination DOAC levels would guide medical decision-making (1) determine potential contribution spontaneous or trauma-induced hemorrhage; (2) identify appropriate candidates reversal, (3) optimize timing surgery intervention. Methods Results The Dipstick test uses disposable strip factor Xa- thrombin inhibitors in...
Background: Pulmonary embolism (PE) requires accurate risk assessment. We investigated the prognostic performance of National Early Warning Score (NEWS) in emergency department patients with PE. Methods: included ≥ 18 years from our PE registry (2017 to 2021), excluding after cardiac arrest or intubation before admission. The primary outcome was a composite 30-day all-cause mortality need for advanced therapy (i.e., systemic catheter-directed thrombolysis). used logistic regression and Cox...
IC43 is a recombinant outer membrane protein-based vaccine against Pseudomonas aeruginosa (P. aeruginosa) consisting of OprF- and OprI- epitopes (Opr, protein; OprF/I, OprF/OprI hybrid vaccine) with an N-terminal His 6 tag (Met-Ala-(His)6-OprF190-342-OprI21-83).The study aimed to confirm the optimal dose in adults regard immunogenicity, safety, tolerability after vaccination three different dosages IC43, compared placebo, investigate potential immune-enhancing effect adjuvant, aluminum...
Abstract Background Our recent drug interaction trial with clopidogrel shows that morphine decreases the concentrations and pharmacodynamic effects of clopidogrel, which could lead to treatment failure in susceptible individuals. We hypothesized consequences drug–drug interactions would be less between ticagrelor. Materials methods Twenty‐four healthy subjects received a loading dose 180 mg ticagrelor together placebo or 5 intravenously randomized, double‐blind, placebo‐controlled, crossover...
Morphine decreases the concentrations and effects of clopidogrel, which could lead to treatment failure in myocardial infarction. To clarify whether more potent P2Y12-inhibitors may provide an effective alternative, we examined drug–drug interactions between morphine prasugrel. Twelve healthy volunteers received 60 mg prasugrel with placebo or 5 intravenously a randomized, double-blind, placebo-controlled, cross-over trial. Pharmacokinetics were determined by liquid chromatography tandem...
IntroductionPlasma histamine levels and D-dimer predict disease severity mortality in advanced septic shock. We hypothesized that increased plasma parallel coagulation activation yield prognostic significance already at a very early stage of bacteremia.Patients methodsThis prospective controlled cohort study enrolled 72 consecutive non-surgical non-ICU-ward inpatients with newly culture-diagnosed bacteremia Pitt Bacteremia score ≤2 to determine the extent release their predictive role on...
ASN100 is a novel antibody combination of two fully human IgG1(κ) monoclonal antibodies (MAbs), ASN-1 and ASN-2, which neutralize six Staphylococcus aureus cytotoxins, alpha-hemolysin (Hla) five bicomponent leukocidins. We assessed the safety, tolerability, serum lung pharmacokinetics in randomized, double-blind, placebo-controlled single-dose-escalation first-in-human study.
Aberrant activation of the classical complement pathway is common underlying pathophysiology orphan diseases such as bullous pemphigoid, antibody-mediated rejection organ transplants, cold agglutinin disease, and warm autoimmune hemolytic anemia. Therapeutic options for these complement-mediated disorders are limited sutimlimab, a humanized monoclonal antibody directed against factor C1s, may be potentially useful inhibition pathway. A phase I, first-in-human, double-blind, randomized,...
Granulocyte colony-stimulating factor (G-CSF) stimulates the bone marrow to produce granulocytes and stem cells is widely used accelerate neutrophil recovery after chemotherapy. Interestingly, specific G-CSF receptors have been demonstrated not only on myeloid cells, but also platelets. Data effects of platelet function are limited partly conflicting. The objective this study was determine effect aggregation in vivo activation. Seventy-eight, healthy volunteers were enrolled into randomised,...
Objective: To date, no study has systematically investigated the impact of drowning-induced asphyxia on hemostasis. Our objective was to test hypothesis that induces bleeding by hyperfibrinolytic disseminated intravascular coagulation. Design: Observational study. Setting: A 2,100-bed tertiary care facility in Vienna, Austria, Europe. Patients: All cases (n = 49) were compared with other patients cardiopulmonary resuscitation 116) and acute promyelocytic leukemia 83). Six drowning victims...
Abstract Background and objective Microcirculatory changes contribute to clinical symptoms disease progression in chronic heart failure ( CHF ). A depression of coronary flow reserve is associated with a lower myocardial capillary density biopsies. We hypothesized that cardiac microcirculation might also be reflected by systemic reduction capillaries visualized sublingual videomicroscopy. The aim was study vivo glycocalyx dimensions patients vs healthy controls. Methods Fifty ischaemic...
There are no dose-finding trials available for rituximab that could guide dosing in non-malignant diseases. We hypothesized currently used doses (≥375 mg/m2) exceed several hundred-fold the half-maximal effective dose, which is most sensitive detecting putative differences between biosimilars and important dose finding. In an open label, exploratory trial healthy volunteers received single infusions of at 0.1, 0.3 or 1.0 mg/m2. Subsequently, a double-blind, randomized two products 0.1...
Abstract The protease-activated receptor-1 (PAR-1) is critically involved in the co-activation of coagulation and inflammatory responses. Vorapaxar a reversible, orally active, low molecular weight, competitive antagonist PAR-1.We investigated effects PAR-1 inhibition by vorapaxar on response, activation coagulation, fibrinolysis endothelium during experimental endotoxemia. In this randomized, double blind, crossover trial, 16 healthy volunteers received bolus infusion 2 ng/kg...
Aims The local pulmonary inflammatory response has a different temporal and qualitative profile compared with the systemic response. Although glucocorticoids substantially downregulate release of acute‐phase mediators, it is not clear whether they have comparable inhibitory effects in human lung compartment. Therefore, we anti‐inflammatory pure glucocorticoid agonist, dexamethasone, on bronchoalveolar lavage blood cytokine concentrations to bronchially instilled endotoxin. Methods In this...
Allergic reactions and angioedema are important immunologic conditions in acute care settings. Prior data indicate an association between symptom severity maximum lysis (ML) thromboelastometry. We aimed to evaluate the dynamics of ML two hours after admission emergency department. determined with thromboelastometry using extrinsic testing (EXTEM, ROTEM®, Werfen GmbH, Munich, Germany) at presentation patients approximately thereafter (after observation interval). The median test was used...
Pulmonary embolism (PE) requires careful risk assessment for informed care decisions. We evaluated the value of National Early Warning Score (NEWS) in patients with PE when used by emergency medical services at first patient contact prehospital phase. In this retrospective observational study, we included adult diagnosed ED General Hospital Vienna, Medical University between January 2017 and December 2021, that were hospitalized services. a regression model to assess association NEWS...