Candice Sabben
A5034286418- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and Diving-Related Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 and healthcare impacts
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Retinal and Optic Conditions
- Neurological Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Cerebral Venous Sinus Thrombosis
- Aortic Thrombus and Embolism
- Infective Endocarditis Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Myasthenia Gravis and Thymoma
- Peripheral Artery Disease Management
- Cerebrovascular and genetic disorders
- Disaster Response and Management
- Polyomavirus and related diseases
Fondation de Rothschild
2018-2025
Fondation Ophtalmologique Adolphe de Rothschild
2014-2023
City and Islington College
2019-2022
Boston Medical Center
2022
Boston University
2022
Neurology, Inc
2022
Hospital de Egas Moniz
2022
University of Thessaly
2022
Sorbonne Université
2013-2021
Assistance Publique – Hôpitaux de Paris
2021
Background and Purpose: Endovascular therapy for tandem occlusion strokes of the anterior circulation is an effective safe treatment. The best treatment approach cervical internal carotid artery (ICA) lesion still unknown. In this study, we aimed to compare functional safety outcomes between different approaches ICA during endovascular acute ischemic due in current clinical practice. Methods: Individual patients’ data were pooled from French prospective multicenter observational ETIS...
Background and Purpose— Acute stroke patients with a large ischemic core may still benefit from mechanical thrombectomy (MT), but the predictors of clinical outcome are not well known after MT. We investigated imaging factors associated good mortality at 90 days in acute baseline treated Methods— Data multicentric prospective ETIS (Endovascular Treatment Ischemic Stroke) registry consecutive MT January 1, 2012, to August 31, 2016, were retrospectively analyzed. Baseline was defined as...
Whether endovascular therapy (EVT) added on best medical management (BMM), as compared to BMM alone, is beneficial in acute ischemic stroke with isolated posterior cerebral artery occlusion unknown.We conducted a multicenter international observational study of consecutive patients admitted within 6 hours from symptoms onset 26 centers the first (P1) or second (P2) segment and treated either BMM+EVT alone. Propensity score inverse probability treatment weighting was used account for baseline...
Background and Purpose— Parenchymal hematoma (PH) is a rare but dreadful complication of acute ischemic stroke with unclear underlying mechanisms. We aimed to study the incidence predictors PH after mechanical thrombectomy. Methods— Data from prospective observational multicenter registry was screened identify patients an anterior circulation large vessel occlusion who underwent Clinical, imaging, procedural characteristics were used for analysis, including brain imaging systematically...
Background and Purpose— Nonagenarians represent a growing stroke population characterized by higher frailty. Although endovascular therapy (ET) is cornerstone of the management acute ischemic related to large vessel occlusion, benefit reperfusion among nonagenarians poorly documented. We aimed assess impact ET-related on functional outcome in this elderly population. Methods— A retrospective analysis clinical imaging data from all patients aged over 90 included ETIS (Endovascular Treatment...
Intravenous thrombolysis (IVT) with alteplase or tenecteplase before mechanical thrombectomy is the recommended treatment for large-vessel occlusion acute ischemic stroke. There are divergent data on whether these agents differ in terms of early recanalization (ER) rates thrombectomy, and little their potential differences stratified by ER predictors such as IVT to evaluation (IVT-to-ER
Background and Purpose— Whether all acute stroke patients with large vessel occlusion need to undergo intravenous thrombolysis before mechanical thrombectomy (MT) is debated as (1) the incidence of post-thrombolysis early recanalization (ER) still unclear; (2) may be harmful in unlikely recanalize; and, conversely, (3) transfer for MT unnecessary highly likely recanalize. Here, we determined predictors ER referred derive prediction scores trial design. Methods— Registries from 4 MT-capable...
To identify early prognostic factors of poor clinical outcome in patients treated by endovascular therapy (EVT) with successful recanalization.We reviewed our monocentric prospectively collected EVT database anterior circulation acute ischemic stroke (AIS) from January 2016 to April 2018 who had achieved recanalization (Thrombolysis Cerebral Infarction score ≥ 2b) at the end procedure. A was defined as a 3-month modified Rankin Scale ≥3.A total 324 were included, among whom 186 (57.4%)...
The efficacy of endovascular therapy in patients with acute ischemic stroke due to tandem occlusion is comparable that for isolated intracranial the anterior circulation. However, optimal management cervical internal carotid artery lesions unknown, especially setting dissection, but emergency stenting (CAS) frequently considered. We investigated safety and CAS dissection current clinical practice. retrospectively analyzed a prospectively maintained database composed 2 merged multicenter...
Background and Purpose- The TST trial (Treat Stroke to Target) evaluated the benefit of targeting a LDL (low-density lipoprotein) cholesterol <70 mg/dL reduce risk cardiovascular events in 2860 patients with ischemic stroke atherosclerotic stenosis cerebral vasculature or aortic arch plaque >4 mm, French Korean population. follow-up lasted median 5.3 years (similar time SPARCL [Stroke Prevention by Aggressive Reduction Cholesterol Level]) 2.0 patients. Exposure duration statin is well-known...
Procedural complications in thrombectomy for large vessel occlusions of the anterior circulation are not well described. We investigated incidence, risk factors, and clinical implications daily practice.We used data from ongoing prospective multicenter observational Endovascular Treatment Ischemic Stroke Registry France. The present study is a retrospective analysis 4029 stroke patients with treated between January 2015 May 2020 18 centers. systematically collected procedural data, incidence...
<h3>Background and Objectives</h3> COVID-19–related inflammation, endothelial dysfunction, coagulopathy may increase the bleeding risk lower efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate safety outcomes AIS COVID-19. <h3>Methods</h3> This was a retrospective multicenter cohort study consecutive receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 June 2021 tested for severe respiratory...
Background and Purpose— We aimed to study the intrarater interrater agreement of clinicians attributing DWI-ASPECTS (Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomography Scores) DWI-FLAIR Imaging–Fluid Attenuated Inversion Recovery) mismatch in patients with acute ischemic stroke referred for mechanical thrombectomy. Methods— Eighteen raters independently scored anonymized magnetic resonance imaging scans 30 participants from a multicentre thrombectomy trial, 2...
Background The association between time to reperfusion and clinical outcome is well known in anterior circulation strokes, whereas the impact of main metrics remains unknown posterior strokes. We investigated effect different intervals from symptom onset on 90-day acute ischemic stroke patients with basilar artery occlusion, especially subset population presenting a low volume baseline diffusion-weighted imaging. Methods Results studied included prospective, multicenter, observational ETIS...
Background Studies on the role of blood pressure ( BP ) variability specifically during mechanical thrombectomy MT are sparse and limited. Moreover, pulse PP has not been considered as a potent hemodynamic parameter to describe . We assessed impact functional outcome in acute ischemic stroke patients with large vessel occlusion Methods Results Acute presenting from January 2012 June 2016 were included. data prospectively collected ETIS (Endovascular Treatment Ischemic Stroke) registry....
<h3>BACKGROUND AND PURPOSE:</h3> Leptomeningeal enhancement can be found in a variety of neurologic diseases such as Susac Syndrome. Our aim was to assess its prevalence and significance leptomeningeal syndrome using 3T postcontrast fluid-attenuated inversion recovery MR imaging. <h3>MATERIALS METHODS:</h3> From January 2011 December 2017, nine consecutive patients with control group 73 multiple sclerosis or clinically isolated were included. Two neuroradiologists blinded the clinical...
Background: Management of extracranial internal carotid artery steno-occlusive lesion during endovascular therapy remains debated. Stent occlusion within 24 hours is a frequent event after acute stenting, and we currently lack large population results. We investigated the incidence, predictors, clinical impact stent stenting in current practice. Methods: Patients treated by with between 2015 2019 5 large-volume endovascular-capable centers were retrospectively analyzed. separated 2 groups...
Background and Purpose: Although statins are effective in secondary prevention of ischemic stroke, they also associated with an increase risk intracranial hemorrhage (ICH) certain conditions. In the TST trial (Treat Stroke to Target), we prespecified exploration predictors incident ICH. Methods: Patients stroke previous 3 months or transient attack within 15 days evidence cerebrovascular coronary artery atherosclerosis were randomly assigned a 1:1 ratio target LDL (low-density lipoprotein)...