A5050200813- Neurological disorders and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Fetal and Pediatric Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Botulinum Toxin and Related Neurological Disorders
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- S100 Proteins and Annexins
- Parkinson's Disease and Spinal Disorders
- Genetic Neurodegenerative Diseases
- Intracranial Aneurysms: Treatment and Complications
- Neuroscience and Neural Engineering
- Spinal Fractures and Fixation Techniques
- Transcranial Magnetic Stimulation Studies
- Virus-based gene therapy research
- Sepsis Diagnosis and Treatment
- Cerebral Palsy and Movement Disorders
- RNA Interference and Gene Delivery
- Spinal Dysraphism and Malformations
National and Kapodistrian University of Athens
2016-2025
University General Hospital Attikon
2014-2024
Stavros Niarchos Foundation
2007-2019
University of Ioannina
2014-2016
St. Anne's University Hospital Brno
2014-2016
University of Tennessee Health Science Center
2014-2016
University Hospital of Ioannina
2016
Evangelismos Hospital
2005-2015
University of Alberta
2014
Eginition Hospital
2014
Three vectors derived from retrovirus, herpes simplex virus type 1 (HSV), and adenovirus were compared in cultured rat 9L gliosarcoma cells for gene transfer efficiency a brain tumor model histologic pattern distribution of foreign delivery, as well associated necrosis inflammation. At multiplicity infection 1, vitro (lacZ Escherichia coli) into was more efficient with either the replication-defective retrovirus vector or replication-conditional thymidine kinase (TK)-deficient HSV than...
Most malignant tumors of the central nervous system do not respond well to chemotherapy. The anticancer drug cyclophosphamide (CPA) is largely ineffective against these neoplasms as its conversion DNA-alkylating, cytotoxic metabolites restricted primarily liver and readily cross blood–brain barrier. Here, we show that brain tumor cells can be sensitized effects CPA, both in culture vivo, by introduction hepatic enzyme responsible for activation cytochrome P450 2B1. Stable transfection rat C6...
Even though statin pretreatment is associated with better functional outcomes and lower risk of mortality in acute ischemic stroke, there are limited data evaluating this association stroke due to large artery atherosclerosis (LAA), which carries the highest early recurrence.Consecutive patients LAA were prospectively evaluated from 7 tertiary-care centers during a 3-year period. Statin pretreatment, demographics, vascular factors, admission discharge severity recorded. The outcome events...
Chronic subdural hematoma (cSDH) is one of the most common neurosurgical entities, especially in elderly population. Diagnosis usually established via a head computed tomography, while an increasing number studies are investigating biomarkers to predict natural history cSDH, including progression and recurrence. Surgical evacuation remains mainstay treatment overwhelming majority cases. Nevertheless, many controversies associated with nuances surgical treatment. We performed systematic...
Endothelial progenitor cells (EPCs) have been suggested to constitute a restoration index of the disturbed endothelium in ICU patients. Neuromuscular electric stimulation (NMES) is increasingly employed prevent comorbidities such as ICU-acquired weakness, which related endothelial dysfunction. The role NMES mobilize EPCs has not investigated yet. purpose this study was explore NMES-induced effects on mobilization septic patients.Thirty-two mechanically ventilated patients (mean ± SD, age 58...
Protein S-100B is an established serum marker of primary and secondary brain damage stroke. A group patients after mild head injury (MHI) develop post-concussion symptoms that interfere with the ability in short-term to return work or undertake certain activities. The aim this study was examine correlation outcome MHI. We studied 100 subjects who were referred Emergency Department (ED) a All had GCS 15 either without loss consciousness (LOC) and/or post-traumatic amnesia (PTA). Serum...
Intratumoral grafting of genetically engineered cells that produce interleukin-4 (IL-4) has been shown to tumor regression as well prolong survival mice harboring intracerebral gliomas. We sought determine whether retroviral-mediated gene delivery into in situ resulted enhanced by IL-4. Two mouse fibroblast lines were obtained: they both secreted similar levels IL-4 but one produced a retrovirus vector bearing the (CRE-MFG-IL-4 cells), whereas other did not (NIH3T3-IL-4 cells). In mixed...