A5071716856- Spine and Intervertebral Disc Pathology
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Meningioma and schwannoma management
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Vascular Malformations Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Pelvic and Acetabular Injuries
- Intracranial Aneurysms: Treatment and Complications
- Advanced MRI Techniques and Applications
- Head and Neck Surgical Oncology
- Neurofibromatosis and Schwannoma Cases
- Spinal Hematomas and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Anesthesia and Pain Management
- Advanced Neuroimaging Techniques and Applications
- COVID-19 and healthcare impacts
- Fetal and Pediatric Neurological Disorders
- Pain Management and Treatment
- ATP Synthase and ATPases Research
- Cerebrospinal fluid and hydrocephalus
- Anatomy and Medical Technology
- CNS Lymphoma Diagnosis and Treatment
Agostino Gemelli University Polyclinic
2018-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
Università Cattolica del Sacro Cuore
2015-2022
University of Udine
2020
Catholic University of America
2013-2018
University of Karachi
2018
The survival benefit in maximizing resection glioblastomas (GBMs) has been demonstrated by numerous studies. true limit of infiltration GBMs an overwhelming obstacle, and several technological advances have introduced to improve the identification residual tumors.To evaluate whether integration 5-aminolevulinic acid (5-ALA) with microbubble contrast-enhanced ultrasound (CEUS) improves tumor impact on extent (EOR), overall (OS), progression-free (PFS).A total 230 GBM procedures were...
OBJECTIVE Intraoperative MRI (iMRI) is the gold-standard technique for intraoperative evaluation of extent resection in brain tumor surgery. Unfortunately, it currently available at only a few neurosurgical centers. A commercially software, Virtual iMRI Cranial, provides an elastic fusion between preoperative and CT (iCT). The aim this study was to evaluate accuracy software determining presence residual tumor. METHODS performed patients who underwent iCT after intracranial resection....
Background/Objectives: Lumbar disc herniation, a complex challenge in spinal health, significantly impacts individuals across diverse age groups. This article delves into the intricacies of this condition, emphasising pivotal role anatomical considerations its understanding and management. Additionally, lumbar discectomy might be considered an “easy” surgery; nevertheless, it carries significant risks. The aim study was to present groundbreaking “three-step approach” with some insight...
Percutaneous pedicle screw (PPS) placement is a key step in several minimally invasive spinal surgery (MISS) procedures. Traditional technique for PPS makes use of C-arm fluoroscopy assistance (FA). More recently, newer intraoperative imaging techniques have been developed PPS, including CT-guided navigation (CTNav). The aim this study was to compare FA and CTNav with regard accuracy, complications, radiation dosage.A total 192 patients degenerative lumbar spondylolisthesis canal stenosis...
Background/Objectives: Degenerative lumbar spine conditions are a major cause of disability, particularly in elderly patients or those with comorbidities. Surgical treatment often combines decompression and stabilization to address pain instability. Pedicle screws the gold standard for but pose challenges compromised bone quality. Interspinous devices have emerged as less invasive alternative, comparative studies limited. This study aimed compare clinical surgical outcomes using pedicle...
Background/Objectives: Lumbar disk herniation (LDH) significantly affects quality of life due to lower back and radiating leg pain. Surgical intervention, such as discectomy, is effective for symptom relief when conservative measures fail; however, psychological factors like anxiety, depression, maladaptive coping strategies may negatively impact surgical outcomes. This study aims assess the role preoperative evaluations in predicting postoperative recovery identify key functional predictors...
Background/Objectives: Degenerative lumbar spine conditions are a major cause of disability, particularly in elderly patients or those with comorbidities. Surgical treatment often combines decompression and stabilization to address pain instability. Pedicle screws the gold standard for but pose challenges compromised bone quality. Interspinous devices have emerged as less invasive alternative, comparative studies limited. This study aimed compare clinical surgical outcomes using pedicle...
OBJECTIVE Approximately half of glioblastoma (GBM) cases develop in geriatric patients, and this trend is destined to increase with the aging population. The optimal strategy for management GBM elderly patients remains controversial. aim study was assess role surgery (≥ 65 years old) based on clinical, molecular, imaging data routinely available neurosurgical departments a prognostic survival score that could be helpful stratifying prognosis patients. METHODS Clinical, radiological,...
Abstract Background Minimally invasive spine surgery is a field of active and intense research. Image-guided percutaneous pedicle screw (PPS) placement valid alternative to the standard free-hand technique, thanks technological advancements that provide potential improvement in accuracy safety. Herein, we describe clinical results surgical technique exploiting integration neuronavigation intraoperative neurophysiological monitoring (IONM) for minimally PPS. Materials Methods An...
Study design: Prospective study. Objective: To evaluate the influence of preoperatively assessed psychosomatic traits on postoperative pain, disability, and quality life outcomes. Summary background data: Anterior cervical discectomy fusion (ACDF) is a widely employed surgical procedure for treating spondylosis. Despite its effectiveness, various studies have reported non-success rates in terms alleviating disability pain. Psychological factors become increasingly recognized as critical...
This study aimed to evaluate the efficacy of mindfulness therapy compared traditional physiotherapy and usual care in alleviating postoperative pain improving functional outcomes patients undergoing lumbar spine surgery during COVID-19 pandemic.
Background/Objectives: Lumbar decompression surgery for degenerative lumbar stenosis is an intervention which addresses a condition affecting many patients. This article presents meticulous three-phase surgical approach, derived from our clinical experiences and intertwining anatomical insights, offering nuanced perspective tailored the educational needs of young spinal surgeons. Methods: Six hundred eighty-seven patients who underwent at single institution were included in present study. A...
Increasing the extent of resection (EOR) is considered a main goal in high grade glioma (HGG) surgery. Significant advancements have been recently made to assist surgery: namely use 5-aminolevulinic acid (5ALA) and application contrast-enhanced ultrasound (CEUS) embody two most introduced tools neuro-oncology field. A combined approach including techniques has suggested literature. Our primary aim identify which conditions CEUS final survey real impact 5-ALA guided context assess...
Despite recent discoveries in genetics and molecular fields, glioblastoma (GBM) prognosis still remains unfavorable with less than 10% of patients alive 5 years after diagnosis. Numerous studies have focused on the research biological biomarkers to stratify GBM patients. We addressed this issue our study by using clinical/molecular image data, which is generally available Neurosurgical Departments order create a prognostic score that can be useful undergoing surgical resection. By random...
Decades of therapeutic and molecular refinements, the prognosis patients with glioblastoma (GBM) still remains unfavorable. Integrative clinical studies allow a better understanding natural evolution GBM. To assess independent predictors overall survival (OS) progression free (PFS) clinical, surgical, radiological variables were evaluated. A novel preoperative volumetric magnetic resonance imaging (MRI) Index for tumor in GBM was investigated.A cohort 195 cases operated newly analyzed....
Neuronavigation of preoperative MRI is limited by several errors. Intraoperative ultrasound (iUS) with navigated probes that provide automatic superposition pre-operative and iUS three-dimensional reconstruction may overcome some these limitations. Aim the present study to verify accuracy an - fusion algorithm improve MR-based neuronavigation accuracy.An using Linear Correlation Combination (LC2)-based similarity metric has been retrospectively evaluated for twelve datasets acquired in...
Background: Anterior cervical discectomy and interbody fusion (ACDF) may be performed with different kinds of stand-alone cages. Tantalum polyetheretherketone (PEEK) are two the most commonly used materials in this procedure. Few comparisons between implants for ACDF have been reported literature. Methods: We a comparison patients who underwent either porous tantalum or PEEK cage, spine surgery units single-level disc herniation. Clinical outcome [Neck Disability Index (NDI), Visual Analog...