A5082394708- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cervical and Thoracic Myelopathy
- Spinal Dysraphism and Malformations
- Cardiac Arrest and Resuscitation
- Spinal Cord Injury Research
- Trauma and Emergency Care Studies
- Head and Neck Surgical Oncology
- Metabolism and Genetic Disorders
- Spinal Hematomas and Complications
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury Research
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Ocular Diseases and Behçet’s Syndrome
- Pelvic and Acetabular Injuries
- Neonatal and fetal brain pathology
- Cerebral Venous Sinus Thrombosis
- Infectious Diseases and Tuberculosis
- Cerebrospinal fluid and hydrocephalus
- Scoliosis diagnosis and treatment
- Mitochondrial Function and Pathology
Centro Hospitalar de Vila Nova de Gaia
2008-2025
Lusíada University of Porto
2019-2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2025
Universidade do Porto
2001-2013
Virginia Commonwealth University Medical Center
2001-2005
Virginia Commonwealth University
2003
Hôpital Lariboisière
2001-2002
University of California, Los Angeles
2002
Faculdade de Medicina do ABC
2001
Hospital de Santo António
1998-1999
Abstract Background The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data available to provide optimal care in this scenario and worldwide variability clinical practice has been documented recent studies. Methods A multidisciplinary consensus panel physicians selected for their established scientific expertise the acute tSCI different specializations was established. World Society Emergency Surgery (WSES) European Association...
Cyclosporin A (CsA) has recently been proposed for use in the early phase after traumatic brain injury (TBI), its ability to preserve mitochondrial integrity experimental models, and thereby provide improved behavioral outcomes as well significant histological protection. The aim of this prospective, randomized, double-blind, dual-center, placebo-controlled trial was evaluate safety, tolerability, pharmacokinetics a single intravenous infusion CsA patients with severe TBI. Fifty adult TBI...
This study presents the results of a systematic literature review conducted to determine most up-to-date information on natural outcome cervical spondylotic myelopathy (CSM) and reliable diagnostic techniques.A search was performed for articles published during last 10 years.The course patients with stenosis signs is quite variable. In no symptoms, but significant stenosis, risk developing approximately 3% per year. Myelopathic are useful clinical diagnosis CSM. However, they not highly...
Object. Glycerol is considered to be a marker of cell membrane degradation and thus cellular lysis. Recently, it has become feasible measure via microdialysis cerebral extracellular fluid (ECF) glycerol concentrations at the patient's bedside. Therefore aim this study was investigate ECF concentration time course after severe traumatic brain injury (TBI) its relationship patient outcome other monitoring parameters. Methods. As soon as possible for up 4 days, 76 severely head-injured patients...
To formulate specific guidelines for the recommendation of subaxial cervical spine injuries concerning classification, management, posttraumatic locked facets and vertebral artery injury. Computerized literature was searched on PubMed google scholar database from 2009 to 2020. For keywords "Sub Axial Cervical Spine Classification," resulting in 22 articles related injury classification system (SLICS) 11 AO (Arbeitsgemeinschaft für Osteosynthesefragen, German "Association Study Internal...
Object. Brain tissue acidosis is known to mediate neuronal death. Therefore the authors measured main parameters of cerebral acid—base homeostasis, as well their interrelations, shortly after severe traumatic brain injury (TBI) in humans. Methods. pH, PCO 2 , PO and/or lactate were 151 patients with head injuries, by using a Neurotrend sensor microdialysis probe. Monitoring was started soon possible and continued for up 4 days. During 1st day following trauma, pH significantly lower,...
The evolution of spinal arthroplasty, a significant journey that began in the 1960s and 1970s, has seen remarkable progress. Initially designed to preserve motion at segments avoid complications associated with fusion surgeries, early designs faced setbacks due rudimentary concepts limited materials. However, 1980s marked turning point development modern total disc replacement concepts, utilizing advanced materials such as titanium polyethylene improve implant longevity integration. 2000s...
Spinal trauma (STx), with or without spinal cord injury (SCI), represents a significant global health burden, particularly in low- and middle-income countries (LMICs). International guidelines often assume the availability of resources for intensive care surgical management, limiting their applicability resource-constrained settings. A resource-adapted approach may improve management these contexts. This study aimed to develop resource-tiered protocols STx SCI, addressing LMIC-specific...
Cervical spondylotic myelopathy (CSM) is a common cause of adult spinal cord dysfunction. Although the therapeutic options for moderate to severe CSM patients have been established well, existing guidelines decisions in mild cases are unclear. We present review literature on conservative treatment and surgery suggest general recommendations applicable various clinical presentations different geographic locations across globe, with due considerations available resources locally prevalent practices.
Multiparameter cerebral monitoring has been widely applied in traumatic brain injury to study posttraumatic pathophysiology and manage head-injured patients (e.g., combining O2 pH sensors with microdialysis). Because a comprehensive approach towards understanding processes will also require functional measures, we have added electrophysiology these modalities by attaching recording electrode the microdialysis probe. These dual-function (microdialysis/electrophysiology) probes were placed...
Lumbar spine stenosis is a common disease with prevalence progressively increasing due to the aging of population. Despite many papers having been published over last decades, there still remain doubts regarding its natural history and appropriate treatment. To overcome these problems reach some globally accepted recommendations, World Federation Neurosurgical Society Spine Committee organized consensus conference on this topic. This paper describes recommendations about efficacy surgical...
Craniovertebral junction (CVJ) trauma is a challenging clinical condition. Being highly mobile functional unit at the of skull and vertebral column, traumatic events in this area may produce devastating neurological complications death. Additionally, many CVJ injuries can be left undiagnosed or even raise difficult treatment dilemmas. We present literature review format recommendations on diagnosis management different scenarios for upper cervical recommendations, which applicable to various...
•Most spinal trauma worldwide occurs in low-and middle-income countries (LMICs). Several factors may limit the applicability of current guidelines as regards early management injury.•The pre-hospital per se LMICs is subject to partial adherence recommendations, with possible impact on patient outcomes.•The use clinical (eg ASIA) and morphological SLIC, TLICS, AO Spine) grading scales not homogeneous.•The availability cost diagnostic equipment, timing emergency imaging can vary significantly...
A bstract : Despite recent advances in our understanding of human traumatic brain injury (TBI) pathophysiology, we still need effective neuroprotective agents. The lack rigorous drug pharmacokinetic studies the “living” is an important cause neuroprotection trials failure TBI research. In past, several drugs have been labeled as inefficient, and even withdrawn from expensive trials, without knowing their actual penetration traumatized brain. injured characterized by increased diffusion...