A5100409056- Inflammatory Bowel Disease
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Immune Response and Inflammation
- Virus-based gene therapy research
- Cytokine Signaling Pathways and Interactions
- Tendon Structure and Treatment
- IL-33, ST2, and ILC Pathways
- Microscopic Colitis
- Asthma and respiratory diseases
- Gastrointestinal motility and disorders
- Inflammasome and immune disorders
- Digestive system and related health
- Eosinophilic Esophagitis
- Immune cells in cancer
- Pregnancy and Medication Impact
- Immune Cell Function and Interaction
- Knee injuries and reconstruction techniques
- Pharmacological Effects of Natural Compounds
- Orthopedic Surgery and Rehabilitation
- Neuropeptides and Animal Physiology
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Renal Diseases and Glomerulopathies
Henan University Huaihe Hospital and Huaihe Clinical Institute
2024
Third Xiangya Hospital
2022-2023
Central South University
2022-2023
The Heart Research Institute
2023
Third Affiliated Hospital of Guangzhou Medical University
2023
Guangzhou Medical University
2023
Shandong University of Traditional Chinese Medicine
2022
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2022
Southern Medical University
2014-2022
Nanfang Hospital
2021-2022
Regulation of macrophage polarization is a promising strategy for treating inflammatory bowel disease [IBD]. Tollip an important negative regulator Toll-like receptor [TLR]-mediated innate immunity with downregulated expression in the colon tissues patients IBD. This study aimed to regulate affect polarization.A molecular, targeted immunotherapy method was developed by linking mannose-modified trimethyl chitosan [MTC] Tollip-expressing plasmids via ionic cross-linking, forming MTC-Tollip...
Racemic salbutamol ((RS)-sal), which consist of the same amount (R)-sal and (S)-sal, has been used for asthma COPD due to its bronchodilation effect. However, effect on repeated dextran sulfate sodium (DSS)-induced chronic colitis not yet investigated. In this study evaluated potential (R)-, (S)-, (RS)-sal in mice with DSS-induced investigated underlying mechanisms. Here, we verified that was significantly attenuated by (R)-sal, evidenced notably mitigated body weight loss, disease activity...
The pathogenesis of Crohn's disease (CD) is unknown; however, angiogenesis known to play an important role in the disease. present research suggests that microRNA-21 (miR-21) may a positive regulatory disordered CD.C57 wild-type mice were divided into 6 groups. On day 0, all 2,4,6-trinitrobenzenesulfonic acid (TNBS) group given enema at concentration TNBS 100 mg/kg mouse body weight (solvent 50% alcohol). In control group, was performed with alcohol. 2, 4, and 6, agomir-21 + agomir injected...
Accumulating evidence has shown many similarities and differences of gene profiles pathways between pediatric adult ulcerative colitis (UC) patients. In this study, we aimed to investigate the shared genes in intestinal tissues UC. Differentially expressed (DEGs) UC were identified via bioinformatic analysis Gene Expression Omnibus datasets GSE87473 GSE126124. Ontology pathway enrichment used analyze overlapped distinguished DEGs. Set Variation Analysis (GSVA) was utilized for contrast...
Ulcerative colitis (UC) is an inflammatory bowel disease that causes continuous mucosal inflammation. Anemonin a natural molecule from the Ranunculaceae and Gramineae plants exerts anti-inflammatory properties. This study aimed to explore effects mechanisms of anemonin on UC.C57BL/6 mice were administered dextran sulphate sodium (DSS; 3% [w/v]) establish animal model UC. Mice treated with intraperitoneal injection anemonin. Body weight activity index (DAI) recorded. Haematoxylin eosin...
Indirubin is considered to have promising potential in the treatment of ulcerative colitis (UC). However, poor aqueous solubility and low bioavailability limit its clinical application. We produced indirubin-loaded bovine serum albumin nanoparticles (INPs) characterized their drug encapsulation efficiency, drug-loading capacity, capacity release indirubin vitro short-term physical stability. also investigated pharmacokinetics INPs mice. then compared curative effects against dextran sulfate...
Introduction: The coagulation cascade thrives as the haematological gatekeeper ensuring equilibrium between blood flow and thrombosis. Under pathological conditions, positive-feedback loops compound upon one another, disrupting this increasing risk of thrombosis embolic events. Cardiac thromboembolism persists culprit behind most ischemic strokes; a majority arising from left atrial appendage. In order to combat disease overcome limitations systemic oral anticoagulants, we developed novel...