Ante Tonkić
A5038711503- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Veterinary medicine and infectious diseases
- Cerebral Venous Sinus Thrombosis
- Drug-Induced Hepatotoxicity and Protection
- Diverticular Disease and Complications
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Colorectal Cancer Screening and Detection
- Spine and Intervertebral Disc Pathology
- Gastrointestinal disorders and treatments
- Trigeminal Neuralgia and Treatments
- Foreign Body Medical Cases
- Vitamin K Research Studies
- Meningioma and schwannoma management
- Abdominal vascular conditions and treatments
- Airway Management and Intubation Techniques
University of Split
2013-2024
University Hospital Centre Zagreb
2024
University Gastroenterology
2020
Klinički Bolnički Centar Split
2010-2019
Ministarstvo Gospodarstva
2013
University of Zagreb
2006-2009
The best approach for Helicobacter pylori management remains unclear. An audit process is essential to ensure clinical practice aligned with standards of care.International multicentre prospective non-interventional registry starting in 2013 aimed evaluate the decisions and outcomes H. by European gastroenterologists. Patients were registered an e-CRF AEG-REDCap. Variables included demographics, previous eradication attempts, prescribed treatment, adverse events outcomes. Data monitoring was...
INTRODUCTION: Antibiotic resistance is one of the main factors that determine efficacy treatments to eradicate Helicobacter pylori infection. Our aim was evaluate effectiveness first-line and rescue against H. in Europe according antibiotics resistance. METHODS: Prospective, multicenter, international registry on management (European Registry Management). All infected culture-diagnosed adult patients registered Spanish Association Gastroenterology-Research Electronic Data Capture from 2013...
INTRODUCTION: The safety of Helicobacter pylori eradication treatments and to what extent adverse events (AEs) influence therapeutic compliance in clinical practice are hardly known. Our aim was assess the frequency, type, intensity, duration AEs, their impact on compliance, for most frequently used “European Registry management.” METHODS: Systematic prospective noninterventional registry European gastroenterologists (27 countries, 300 investigators) management H. infection routine practice....
Catestatin (CST) is an important peptide in the pathophysiology of chronic inflammatory disorders. However, clinical studies on bowel disease (IBD) patients are lacking. Our goal was to investigate CST concentrations IBD compared healthy subjects. Additionally, we aimed determine arterial stiffness parameters relation CST. This cross-sectional study 80 (45 Crohn’s (CD) and 35 ulcerative colitis (UC) patients) with 75 control Serum levels were significantly higher group subjects (11.29 ± 9.14...
Experience in Helicobacter pylori eradication treatment of patients allergic to penicillin is very scarce. A triple combination with a PPI, clarithromycin (C), and metronidazole (M) often prescribed as the first option, although more recently use quadruple therapy bismuth (B), tetracycline (T), M has been recommended.To evaluate efficacy safety first-line rescue treatments "European Registry H management" (Hp-EuReg).A systematic prospective registry clinical practice European...
Abstract Adropin is a novel peptide mostly associated with energy homeostasis and vascular protection. To our knowledge, there are no studies that investigated its relationship inflammatory bowel diseases (IBD). The aim of this study was to compare serum adropin levels between 55 patients IBD (30 Ulcerative colitis (UC) patients, 25 Crohn’s disease (CD) patients) 50 age/gender matched controls. Furthermore, we explored correlations severity scores, hsCRP, fecal calprotectin, fasting glucose...
Abstract Limited evidence exists regarding cognitive and psychomotor function in patients with inflammatory bowel disease (IBD). Therefore, we aimed to compare the neurocognitive of 60 IBD age/sex-matched controls. Computer-based instrument Complex Reactinometer Drenovac (CRD) was used for assessment domains: convergent thinking (simple mathematical tasks; CRD-11), perceptive abilities (light signal position discrimination; CRD-311) sophisticated operative (complex coordination; CRD-411)....
The prevalence of Helicobacter pylori remains high in the older population. Specific age-related peculiarities may impact outcomes H. treatment. aim study was to evaluate diagnostics and effectiveness eradication between younger European populations. "European Registry on Management (Hp-EuReg)" data from 2013 2022 were analyzed. Patients divided into (≥ 60 years) (18-59 groups. Modified intention-to-treat (mITT) per-protocol (PP) analysis performed. 49,461 patients included which 14,467...
Several methods are available to diagnose Helicobacter pylori infection. Our objective was evaluate the tests used for both initial diagnosis and confirmation of eradication after treatment in Europe.The European Registry on management infection is an international, multicentre, prospective, non-interventional registry aiming pylori-infected patients Europe. Countries with at least 100 cases registered from June 2013 April 2021, a validated diagnostic method were analysed. Data quality...
BACKGROUND Population of patients with inflammatory bowel disease (IBD) is burdened by various extraintestinal manifestations which substantially contribute to greater morbidity and mortality. Growth-differentiation factor-15 (GDF-15) often over-expressed under stress conditions, such as inflammation, malignancies, heart failure, myocardial ischemia, many others. AIM To explore the association between GDF-15 IBD serum concentrations were shown be an independent predictor poor outcomes in...
The primary objective of this study was to compare concomitant and hybrid therapy in the first line eradication treatment Helicobacter pylori infection Split-Dalmatia County, Croatia, which clarithromycin resistance is above 20%. secondary determine compliance adverse events rate between these therapeutic protocols.In an open-label, randomised clinical trial 140 patients total with H. were randomly assigned either (esomeprazole 40 mg, amoxicillin 1 g, metronidazole 500 twice daily for 14...
Point mutations in the 23S rRNA, gyrA, and gyrB genes can confer resistance to clarithromycin (CAM) levofloxacin (LVX) by altering target sites or protein structure, thereby reducing efficacy of standard antibiotics treatment Helicobacter pylori infections. Considering confirmed primary CAM LVX H. infected patients from southern Croatia, we performed a molecular genetic analysis three (23S gyrB) PCR sequencing, together with computational docking analysis. In CAM-resistant isolates, mutation...
Most ingested foreign bodies will pass uneventfully through the gastrointestinal tract. Nevertheless, long and rigid are associated with an increased risk of impaction, perforation bleeding. Moreover, there has been no case spontaneous passage a toothbrush reported. Therefore, prompt removal such objects is recommended before complications develop. This report describes 18-year-old woman who accidentally swallowed her toothbrush. The was successfully removed via flexible endoscopy using...