A5071649504- Congenital heart defects research
- Animal Genetics and Reproduction
- Pluripotent Stem Cells Research
- Cancer Cells and Metastasis
- Developmental Biology and Gene Regulation
- Renal and related cancers
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Hemispheric Asymmetry in Neuroscience
- Tissue Engineering and Regenerative Medicine
- RNA modifications and cancer
- Zebrafish Biomedical Research Applications
- Hedgehog Signaling Pathway Studies
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Neonatal Respiratory Health Research
- Down syndrome and intellectual disability research
- Bone Metabolism and Diseases
- Congenital Heart Disease Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hippo pathway signaling and YAP/TAZ
- Marine Ecology and Invasive Species
- Cellular Mechanics and Interactions
- MicroRNA in disease regulation
- Educational Practices and Sociocultural Research
Universidad de Jaén
2023-2024
Cardiovascular Research Center
2024
Spanish National Centre for Cardiovascular Research
2021-2023
Instituto de Neurociencias
2006-2021
Consejo Superior de Investigaciones Científicas
2006-2012
Instituto Cajal
2004
University of Buenos Aires
2001-2003
The Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs), endowing epithelial cells with migratory and invasive properties during both embryonic development tumor progression. During EMT, provokes the loss of markers, as well changes in cell shape expression mesenchymal markers. Here, we show that addition to inducing dramatic phenotypic alterations, attenuates cycle confers resistance death induced by withdrawal survival pro-apoptotic signals. Hence,...
Abstract The epithelial-to-mesenchymal transition (EMT) and the unjamming (UJT) each comprises a gateway to cellular migration, plasticity remodeling, but extent which these core programs are distinct, overlapping, or identical has remained undefined. Here, we triggered partial EMT (pEMT) UJT in differentiated primary human bronchial epithelial cells. After triggering UJT, cell-cell junctions, apico-basal polarity, barrier function remain intact, cells elongate align into cooperative...
Abstract The Epithelial to Mesenchymal Transition (EMT) regulates cell plasticity during embryonic development and in disease. It is dynamically orchestrated by transcription factors (EMT-TFs), including Snail, Zeb, Twist Prrx, all activated TGF-β among other signals. Here we find that Snail1 Prrx1, which respectively associate with gain or loss of stem-like properties bad good prognosis cancer patients, are expressed complementary patterns vertebrate cancer. We show this complementarity...
In developing amniote embryos, the first epithelial-to-mesenchymal transition (EMT) occurs at gastrulation, when a subset of epiblast cells moves to primitive streak and undergoes EMT internalize generate mesoderm endoderm. We show that in chick embryo this decision is mediated by reciprocal transcriptional repression Snail2 Sox3 factors. also relationship between Snail conserved mouse human cancer cells. embryo, Snail-expressing ingress streak, whereas Sox3-positive cells, which are unable...
Notch signalling is used throughout the animal kingdom to spatially and temporally regulate cell fate, proliferation differentiation. Its importance reflected in dramatic effects produced on both development health by small variations strength of signal. The Down-syndrome-associated kinase DYRK1A coexpressed with various tissues during embryonic development. Here we show that moves nuclear transcription compartment where it interacts intracellular domain promoting its phosphorylation ankyrin...
We analysed the role of Notch signalling during specification dorsal midline in Xenopus embryos. By activating or blocking pathway we found that expands floor plate domain sonic hedgehog and pintallavis represses notochordal markers chordin brachyury, with a concomitant reduction notochord size. propose within population early organiser equivalent potential to develop either as plate, activation favours development at expense notochord, preferentially before mid gastrula. present evidence...
Snail and Zeb transcription factors induce epithelial-to-mesenchymal transition (EMT) in embryonic adult tissues by direct repression of E-cadherin transcription. The the EMT inducers Snail1 Zeb2 plays a fundamental role defining territories mouse, as needs to be downregulated primitive streak epiblast, concomitant with formation mesendodermal precursors neural plate, respectively. Here, we show that chick embryo, is weakly expressed epiblast at pre-primitive stages where it substituted for...
ABSTRACT Tracing and manipulating cells in embryos are essential to understand development. Lipophilic dye microinjections, viral transfection iontophoresis have been key map the origin of progenitor that form different organs post-implantation mouse embryo. These techniques require advanced manipulation skills only iontophoresis, a demanding approach limited efficiency, has used for single-cell labelling. Here, we perform lineage tracing local gene ablation using cell-permeant Cre...
The mammalian heart is a complex organ formed during development via highly diverse populations of progenitor cells. origin, timing recruitment, and fate these progenitors are vital for the proper this organ. molecular mechanisms that govern morphogenesis essential understanding pathogenesis congenital diseases embryonic cardiac regeneration. Classical approaches to investigate employed generation transgenic mice assess function specific genes development. However, mouse transgenesis...
The mammalian heart is a complex organ formed during development via highly diverse populations of progenitor cells. origin, timing recruitment, and fate these progenitors are vital for the proper this organ. molecular mechanisms that govern morphogenesis essential understanding pathogenesis congenital diseases embryonic cardiac regeneration. Classical approaches to investigate employed generation transgenic mice assess function specific genes development. However, mouse transgenesis...
The Spanish Society for Developmental Biology (SEBD) organized its 17th meeting in November 2020 (herein referred to as SEBD2020). This meeting, originally programmed take place the city of Bilbao, was forced onto an online format due SARS-CoV2, COVID-19 pandemic. Although, we missed live personal interactions and out on Bilbao social scene, were able meet present our work discuss latest results. An overview activities that took around different scientific sessions speakers involved are...