A5038587842- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Meta-analysis and systematic reviews
- Immunotherapy and Immune Responses
- Traumatic Brain Injury Research
- Acute Lymphoblastic Leukemia research
- Neurology and Historical Studies
- Health Systems, Economic Evaluations, Quality of Life
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Innovations in Medical Education
- Autoimmune and Inflammatory Disorders Research
- Sphingolipid Metabolism and Signaling
- Monoclonal and Polyclonal Antibodies Research
- HIV Research and Treatment
- RNA Interference and Gene Delivery
- Rheumatoid Arthritis Research and Therapies
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Mental Health and Psychiatry
- Pharmaceutical industry and healthcare
- Systemic Sclerosis and Related Diseases
- Prion Diseases and Protein Misfolding
- Effects of Vibration on Health
University of Colorado Denver
2015-2025
University of Colorado Anschutz Medical Campus
2011-2024
Rocky Mountain MS Center
2014-2024
Neurology, Inc
2003-2023
University of Colorado System
2020-2023
University of Pennsylvania
1986-2022
Lou Ruvo Brain Institute
2018-2022
Cleveland Clinic
2018-2022
Medical College of Wisconsin
2022
The Neurological Institute
2022
<h3>Background</h3> Neuromyelitis optica (NMO)–IgG is a specific autoantibody marker for NMO. It binds selectively to aquaporin 4 (AQP4), which highly concentrated in astrocytic foot processes at the blood-brain barrier and not restricted optic nerve spinal cord. Although it conventionally believed that brain spared, imaging abnormalities are uncommon patients with <h3>Objective</h3> To investigate location of lesions distinctive NMO respect localization AQP4 mammalian brain. <h3>Design</h3>...
<h3>Objective:</h3> To estimate the US commercially insured multiple sclerosis (MS) annual prevalence from 2008 to 2012. <h3>Methods:</h3> The study was a retrospective analysis using PharMetrics Plus, nationwide claims database for over 42 million covered representative lives. Annual point required insurance eligibility during an entire year. Our primary MS identification algorithm 2 inpatient coded ICD-9 340 or 3 outpatient 1 MS-indicated disease-modifying therapy claim. Age-adjusted...
Abstract Single-cell RT-PCR was used to sample CD19+ B cell repertoires in cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) or viral meningitis. Analysis amplified Ab H and L chain products served identify the rearranged germline segment J segment, determine degree homology for sequence individual cells. The repertoire meningitis CSF predominately polyclonal, whereas clonal expansion a prominent feature IgG three four MS patients. Two dominant populations one accounted ∼70%...
Advancements in imaging technologies and newly evolving treatments offer the promise of more effective management strategies for MS. Until recently, confirmation diagnosis MS has generally required demonstration clinical activity that is disseminated both time space. Nevertheless, with advent MRI techniques, occult disease can be demonstrated 50 to 80% patients at first presentation. Prospective studies have shown presence such lesions predicts future conversion clinically definite (CD)...
Fatigue and impaired upright postural control (balance) are the 2 most common findings in people with multiple sclerosis (MS), treatment approaches varying greatly effectiveness. The aim of this study was to investigate benefits implementing a vestibular rehabilitation program for purpose decreasing fatigue improving balance patients MS. 14-week, single-blinded, stratified blocked randomized controlled trial. Measurements were conducted an outpatient clinical setting, interventions performed...
Multiple sclerosis (MS) is a chronic neuroinflammatory condition of the central nervous system (CNS). It major cause neurological disability in young adults, particularly women. What triggers destruction myelin sheaths covering nerve fibres unknown. Both genetic and infectious agents have been implicated. Of agents, Epstein-Barr virus (EBV), common herpesvirus, has strongest epidemiological serological evidence. However, presence EBV CNS demonstration underlying mechanism(s) linking to...
Infusion of PDA-001, a preparation mesenchymal-like cells derived from full-term human placenta, is new approach in the treatment patients with multiple sclerosis.This safety study aimed to rule out possibility paradoxical exacerbation disease activity by PDA-001 was phase 1b, multicenter, randomized, double-blind, placebo-controlled, 2-dose ranging including relapsing-remitting sclerosis or secondary progressive sclerosis. The conducted at 6 sites United States and 2 Canada. Patients were...
Studies investigating rates and risk factors for serious safety events (SSEs) during rituximab treatment of multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), related are limited.Rituximab-treated patients with MS, NMOSD, or at the Rocky Mountain New York University MS Care Centers were included. The follow-up period was defined as time from initial dose up to 12 months last ocrelizumab (in who switched). Clinician-reported laboratory data retrospectively collected...
Strategies for sequencing disease modifying therapies (DMTs) in multiple sclerosis (MS) patients include escalation, high efficacy early, induction, and de-escalation.To provide a perspective on de-escalation, which aims to match the ratio of DMT benefit/risk aging patients.We reanalyzed data from retrospective, real-world cohort MS model activity oral (dimethyl fumarate fingolimod) higher infusible (natalizumab rituximab) DMTs by age. For with relapsing MS, we conducted controlled,...
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of unknown cause that afflicts the central nervous system. MS typified by highly clonally restricted antigen-driven antibody response confined largely to The major antigenic targets this and role in pathogenesis remain unclear. To help resolve these issues, we cloned IgG repertoire directly from active plaque periplaque regions brain B cells recovered cerebrospinal fluid patient with subacute disease. We found...