A5044583406- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Intraperitoneal and Appendiceal Malignancies
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Estrogen and related hormone effects
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Spectroscopy Techniques in Biomedical and Chemical Research
- Hepatitis B Virus Studies
- Genital Health and Disease
- Molecular Biology Techniques and Applications
- Maternal and Perinatal Health Interventions
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Gynecological conditions and treatments
- Immunotherapy and Immune Responses
Royal Women's Hospital
2014-2024
The University of Melbourne
2012-2024
Washington University in St. Louis
2018-2024
Harvard University
2017-2024
Boston Children's Hospital
2024
Joseph M. Still Research Foundation
2024
Eisenhower Medical Center
2024
University of Tasmania
2023
St. Jude Children's Research Hospital
2023
Royal Ottawa Mental Health Centre
1980-2023
The ICON7 trial previously reported improved progression-free survival in women with ovarian cancer the addition of bevacizumab to standard chemotherapy, greatest effect patients at high risk disease progression. We report final overall results trial.ICON7 was an international, phase 3, open-label, randomised undertaken 263 centres 11 countries across Europe, Canada, Australia and New Zealand. Eligible adult newly diagnosed that either high-risk early-stage (International Federation...
# Effect of screening on incidence and mortality from cancer cervix in England: evaluation based routinely collected statistics {#article-title-2} Objective: To assess the impact cervical cancer. Design: Comparison age specific before after introduction national call recall system 1988. Setting: England. Subjects: Women aged over 19 years. Results: From mid-1960s, number smears taken rose continuously to 4.5 million at end 1980s. Between 1988 1994, coverage target group doubled around 85%....
The Gynecological Cancer Intergroup (GCIG) has previously reached consensus regarding the criteria that should be used in clinical trial protocols to define progression-free survival after first-line therapy as well response treatment recurrent disease using serum marker CA 125 and specified situations where these used. However, publications did not include detailed definitions, nor were they written accommodate new version of Response Evaluation Criteria In Solid Tumors (RECIST) (version...
BackgroundAlthough women with endometrial cancer generally have a favourable prognosis, those high-risk disease features are at increased risk of recurrence. The PORTEC-3 trial was initiated to investigate the benefit adjuvant chemotherapy during and after radiotherapy (chemoradiotherapy) versus pelvic alone for cancer.MethodsPORTEC-3 an open-label, international, randomised, phase 3 involving 103 centres in six clinical trials collaborating Gynaecological Cancer Intergroup. Eligible had...
Mononuclear phagocytes are important modulators of Alzheimer's disease (AD), but the specific functions resident microglia, bone marrow-derived mononuclear cells, and perivascular macrophages have not been resolved. To elucidate spatiotemporal roles during disease, we targeted myeloid cell subsets from different compartments examined pathogenesis in three mouse models AD ( APP swe/PS1 , swe APP23 mice). We identified chemokine receptor 2 (CCR2)-expressing cells as population that was...
Epithelial mesenchymal transition (EMT) and cancer stem cells (CSC) have been associated with resistance to chemotherapy. Eighty percent of ovarian patients initially respond platinum-based combination therapy but most return recurrence ultimate demise. To better understand such chemoresistance we assessed the potential role EMT in tumor collected from advanced-stage cell line OVCA 433 response cisplatin vitro. We demonstrate that cisplatin-induced epithelial morphology residual correlated...
Tumor cells in ascites are a major source of disease recurrence ovarian cancer patients. In an attempt to identify and profile the population obtained from patients, novel method was developed separate adherent (AD) non-adherent (NAD) culture. Twenty-five patients were recruited this study; 11 chemonaive (CN) 14 chemoresistant (CR). AD both CN CR exhibited mesenchymal morphology with antigen stem fibroblasts. Conversely, NAD had epithelial enhanced expression 125 (CA125), cell adhesion...
Clinicopathologic data from a population-based endometrial cancer cohort, unselected for age or family history, were analyzed to determine the optimal scheme identification of patients with germline mismatch repair (MMR) gene mutations.Endometrial cancers 702 recruited into Australian National Endometrial Cancer Study (ANECS) tested MMR protein expression using immunohistochemistry (IHC) and MLH1 promoter methylation in MLH1-deficient cases. mutation testing was performed on DNA MMR-protein...
To provide resource-stratified, evidence-based recommendations on the secondary prevention of cervical cancer globally.
Abstract Of the few factors known to be associated with epithelial ovarian cancer, most consistently observed relate women's reproductive function, although even here uncertainties remain. We have undertaken a case‐control study involving personal interviews over 1,600 women, largest of its kind date, investigate further associations between histories and other development cancer. Cases were drawn from women diagnosed cancer in 3 Australian states, Queensland, New South Wales Victoria,...
Inhibin is an ovarian hormone that inhibits the secretion of follicle-stimulating (FSH) by anterior pituitary gland. Women with granulosa-cell tumors ovary have elevated serum inhibin concentrations, but whether concentrations are increased in women other unknown.
The ovarian surface epithelium (OSE) is the precursor of common epithelial carcinomas. In present study, we examined molecular mechanisms and possible physiological basis for propensity OSE cells to undergo epithelio-mesenchymal transition (EMT) in response environmental influences. We hypothesized that EMT may be a homeostatic mechanism permits displaced assume stromal phenotype within cortex. report EGF conjunction with hydrocortisone EMT-inducing factor as shown by changes fibroblast-like...
Abstract Over 80% of women diagnosed with advanced-stage ovarian cancer die as a result disease recurrence due to failure chemotherapy treatment. In this study, using two distinct cell lines (epithelial OVCA 433 and mesenchymal HEY) we demonstrate enrichment in population cells high expression CSC markers at the protein mRNA levels response cisplatin, paclitaxel combination both. We also significant enhancement sphere forming abilities drugs. The results these vitro findings are supported by...
Proteomic technologies are being used to discover and identify disease-associated biomarkers. The application of these in the search for potential diagnostic/prognostic biomarkers serum patients has been limited by presence highly abundant albumin immunoglobulins that constitute approximately 60-97% total proteins. purpose study was evaluate whether treatment human with Affi-Gel Blue alone or combination Protein A (Aurum protein mini kit, Bio-Rad) before two-dimensional gel electrophoresis...
FTIR microscopy was applied to the analysis of cell types and other variables present in Pap smears ascertain limitations infrared spectroscopy diagnosis cervical cancer dysplasia. It found that leukocytes, particular lymphocytes, have spectral features phophodiester region (1300-900 cm−1) suggestive what has previously been described as changes indicative malignancy. Endocervical cells fibroblasts similar HeLa consequently could also confound diagnosis. The use ethanol a fixative...