A5002784480- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Alzheimer's disease research and treatments
- Cardiovascular Health and Disease Prevention
- Health, Environment, Cognitive Aging
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- GDF15 and Related Biomarkers
- Cardiovascular Health and Risk Factors
- Heart Rate Variability and Autonomic Control
- Nutritional Studies and Diet
- Intensive Care Unit Cognitive Disorders
- Advanced Neuroimaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Neurological Disorders and Treatments
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Heart rate and cardiovascular health
- MRI in cancer diagnosis
- Statistical Methods in Clinical Trials
- Cholinesterase and Neurodegenerative Diseases
- Optical Imaging and Spectroscopy Techniques
- Hemodynamic Monitoring and Therapy
- Cerebral Venous Sinus Thrombosis
Alzheimer's Association
2024-2025
Northwestern University
2018-2024
Microwave Monolithics (United States)
2020-2021
Northwestern Memorial Hospital
2020
University of Helsinki
2019
Helsinki University Hospital
2019
UNSW Sydney
2019
Leiden University Medical Center
2015-2018
University of Glasgow
2015-2016
University of Milan
2015
<h3>Objective</h3> To address the variability in prevalence estimates and inconsistencies potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach individual participant data (IPD) from international cohorts Stroke Cognition Consortium (STROKOG) consortium. <h3>Methods</h3> We harmonized 13 studies based 8 countries. Neuropsychological test scores 2 to 6 months after stroke or TIA appropriate normative were used calculate domain scores. Domain-specific...
High blood pressure (BP) is a known risk factor for mobility and cognitive impairment in older adults. This study tested the association of cumulative BP exposure from young adulthood to midlife with gait function midlife. Furthermore, we whether these associations were modified by cerebral white matter hyperintensity (WMH) burden.We included 191 participants CARDIA (Coronary Artery Risk Development Young Adults), community-based cohort individuals followed over 30 years. Cumulative was...
<h3>Background:</h3> Heart rate and heart variability, markers of cardiac autonomic function, have been linked with cardiovascular disease. We investigated whether variability are associated functional status in older adults, independent <h3>Methods:</h3> obtained data from the Prospective Study Pravastatin Elderly at Risk (PROSPER). A total 5042 participants were included present study, mean follow-up was 3.2 years. derived baseline 10-second electrocardiograms. defined as standard...
<h3>Objective:</h3> To investigate the cross-sectional and longitudinal associations of 10-second heart rate variability (HRV) with various domains cognitive function in older participants at risk cardiovascular disease. <h3>Methods:</h3> We studied 3,583 participants, mean age 75.0 years, who were enrolled Prospective Study Pravastatin Elderly Risk. From baseline ECGs, standard deviation normal-to-normal intervals was calculated as index HRV. Four assessed repeated during a follow-up period...
Abstract Introduction We assessed the association between visit‐to‐visit blood pressure variability (BPV) up to 12 years and subsequent dementia risk, tested modifying effect of antihypertensive medications. Methods studied 2234 participants from two community‐based cohorts older adults with normal cognition or mild cognitive impairment. Participants were followed through annual assessments for 27 years. Visit‐to‐visit BPV was quantified over 3, 6, 9, years, respectively. Results Higher...
Abstract The emergence of the United States Food and Drug Administration (FDA)‐approved amyloid‐targeting therapies for Alzheimer's disease challenges clinicians healthcare providers with a transformative landscape. Effectively communicating risks, benefits, burdens, costs, available support associated these novel disease‐modifying treatments to patients, families, other is essential but complex. In response, Association's Clinical Meaningfulness Workgroup has proposed language surrounding...
Patients with advanced heart failure run a greater risk of dementia. Whether early cardiac structural changes also associate cognitive decline is yet to be determined.We tested whether left ventricular hypertrophy (LVH) derived from electrocardiogram associates in older subjects at cardiovascular disease.We included 4,233 participants (mean age 75.2 years, 47.8% male) PROSPER (PROspective Study Pravastatin the Elderly Risk). LVH was assessed baseline electrocardiograms by measuring...
Animal studies suggest the involvement of natriuretic peptides (NP) in several brain functions that are known to be disturbed during Alzheimer's disease (AD). However, it remains unclear whether such findings extend humans. In this study, we aimed to: (1) map gene expression and localization NP their receptors (NPR) human post-mortem tissue; (2) compare relative amounts NPR between tissue AD patients non-demented controls, (3) cerebrospinal fluid (CSF) controls. Using publicly available...
An abnormally wide spatial QRS-T angle on an ECG is a marker of heterogeneity in electrical activity cardiac ventricles and linked with cardiovascular events. Growing evidence suggests that dysfunction might signal future cognitive decline.In this study, we investigated whether associates decline older subjects at high risk.We included 4,172 men women (mean age 75.2±3.3 years) free arrhythmias from the PROSPER cohort. Spatial was calculated baseline 12-lead ECGs using matrix transformation...
Abstract In this study, we perform a region of interest diffusion tensor imaging and advanced complexity analysis normal appearing white matter to determine the impact vascular health on these diffusivity metrics in midlife adults. 77 participants (26 black, 35 female) at year 30 visit Coronary Artery Risk Development Young Adults longitudinal study were scanned with an diffusion-weighted fluid-attenuated inversion recovery protocol. Fractional anisotropy non-linear measures estimated....
Abstract Here we highlight the Alzheimer's Association's role since its inception, as a strategic collaborator with National Institutes of Health–National Institute on Aging in development modern era Movement and making disease (AD) national priority United States by developing several initiatives to advance knowledge about cause, diagnosis, treatment dementia. Among these collaborative undertakings, Disease Neuroimaging Initiative (ADNI) is an exemplary case, launched groundwork Working...
Background Dual‐venc 4D flow MRI, recently introduced for the assessment of intracranial hemodynamics, may provide a promising complementary approach to well‐established tools such as transcranial Doppler ultrasound (TCD) and overcome some their disadvantages. However, data comparing measures from dual‐venc MRI TCD are lacking. Purpose To compare cerebral blood velocity derived TCD. Study Type Prospective cohort. Subjects A total 25 healthy participants (56 ± 4 years old, 44% female). Field...
Abstract Introduction To test the association of vascular health (VH) across young adulthood with midlife dynamic cerebral autoregulation (dCA), gait, and cognition; to whether dCA is a modifying factor. Methods We studied 196 participants from Coronary Artery Risk Development in Young Adults cohort who were followed over 30 years. VH was assessed at each visit according American Heart Association recommendations. At year 30, measured using transcranial Doppler ultrasound several gait...