A5053856468- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Cerebrospinal fluid and hydrocephalus
- Cholinesterase and Neurodegenerative Diseases
- Cerebrovascular and Carotid Artery Diseases
- Hereditary Neurological Disorders
- Blood Pressure and Hypertension Studies
- Spinal Dysraphism and Malformations
- Peripheral Neuropathies and Disorders
- Neurological Disorders and Treatments
- Intramuscular injections and effects
- Frailty in Older Adults
- Spinal Cord Injury Research
- Circadian rhythm and melatonin
- Traumatic Brain Injury and Neurovascular Disturbances
- Health and Wellbeing Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Health Systems, Economic Evaluations, Quality of Life
- Cognitive Functions and Memory
- Toxoplasma gondii Research Studies
- Bacterial Infections and Vaccines
- Pneumocystis jirovecii pneumonia detection and treatment
- Acute Ischemic Stroke Management
- Sleep and related disorders
José R. Reyes Memorial Medical Center
2023-2025
National University Health System
2019-2024
National University Hospital
2020-2024
National University of Singapore
2019-2024
Memorial Medical Center
2022
Erasmus MC
2020
Amsterdam UMC Location Vrije Universiteit Amsterdam
2020
National Hospital for Neurology and Neurosurgery
2019
University College London
2019
Katsushika Medical Center
2019
To evaluate the association between brain amyloid β (Aβ) and cerebral small vessel disease (CSVD) markers, as well their joint effect on cognition, in a memory clinic study.A total of 186 individuals visiting clinic, diagnosed with no cognitive impairment, impairment dementia (CIND), Alzheimer (AD), or vascular were included. Brain Aβ was measured by [11C] Pittsburgh compound B-PET global standardized uptake value ratio (SUVR). CSVD markers including white matter hyperintensities (WMH),...
Hemorrhagic pyogenic cerebral abscesses are a rare clinical entity that can present diagnostic challenges and lead to treatment delays. We report case of 46-year-old female who initially presented with sudden onset focal neurological deficits, raising suspicion cerebrovascular etiology. Further workup revealed hemorrhagic brain abscess. The patient was managed successfully conservative approach, receiving medical after declining surgical intervention, discharged only minimal residuals....
There are major challenges in determining the etiology of vascular cognitive impairment (VCI) clinically, especially presence mixed pathologies, such as and amyloid. Most recently, two criteria (American Heart Association/American Stroke Association (AHA/ASA) Diagnostic Statistical Manual Mental Disorders, Fifth Edition (DSM-V)) have been proposed for clinical diagnosis VCI but not yet validated using neuroimaging.
Various blood biomarkers reflecting brain amyloid-β (Aβ) load have recently been proposed with promising results. However, to date, no comparative study amongst has reported. Our objective was examine the diagnostic performance and cost effectiveness of three on same cohort.Using cohort (n = 68), performances single-molecule array (Simoa) Aβ40, Aβ42, Aβ42/Aβ40 amplified plasmonic exosome (APEX) Aβ42 were compared using amyloid positron emission tomography (PET) as reference standard. The...
Abstract Hypertension is a global public health challenge that imposes significant burden on patients and healthcare systems. Conventional treatment involves dose escalation of an antihypertensive drug, if the desired response not achieved, are prescribed another often in combination with other therapies. Importantly, drug synergy dose‐, time‐ patient‐dependent. Coupled challenges intra‐ inter‐individual variability, standard care can lead to sub‐optimal outcomes, additional visits,...
Abstract Background The underlying cause of cognitive decline in individuals who are positive for biomarkers neurodegeneration (N) but negative amyloid‐beta (A), designated as Suspected non‐Alzheimer's pathophysiology (SNAP), remains unclear. We evaluate whether cerebrovascular disease (CeVD) is more prevalent those with SNAP compared to A−N− and A+N+ CeVD associated over time patients. Methods A total 216 from a prospective memory clinic cohort (mean [SD] age, 72.7 [7.3] years, 100 women...
Background: P-wave terminal force in lead V1 (PTFV1) on electrocardiography has been associated with atrial fibrillation and ischemic stroke. Objective: To investigate whether PTFV1 is cerebral small vessel disease (CSVD) markers etiological subtypes of cognitive impairment dementia. Methods: Participants were recruited from ongoing memory clinic study between August 2010 to January 2019. All participants underwent physical medical evaluation along an 3 T brain magnetic resonance imaging....
Bilateral scapular winging is a rare and atypical manifestation of Arnold-Chiari malformation type 1 (ACM1). We report case ACM with extensive syrinx formation, presenting progressive bilateral proximal upper extremity weakness, winging, segmental hypesthesia reduced thermesthesia over the C2-C8 dermatomal levels. The patient was successfully treated surgical decompression syringosubarachnoid shunting. This unusual presentation ACM1 emphasizes need to consider central nervous system...
We describe a 24-year old man diagnosed with Down syndrome who developed intracranial germinona located at the pineal region presented no ophthalmologic signs on neurologic examination admission. However, after external ventricular device (EVD) insertion, patient upward gaze palsy and convergence retraction nystagmus.
Background: Decompressive hemicraniectomy (DHC) is a surgical procedure in which substantial piece of the cranium removed to reduce intracranial pressure. DHC improves mortality. Although may be lifesaving, many survivors suffer from severe neurological impairment, patients and primary caregivers have deal with afterward. This study’s purpose understand better caregiver’s perception regarding burden outcome DHC. Methods: was descriptive, prospective study that included all who had previously...
It has been a great pleasure to host the 11th Meeting of Hydrocephalus Society (International for and Cerebrospinal Fluid Disorders) in
Guillain-Barré Syndrome (GBS) is a complex autoimmune disorder where person’s own immune system damages the nerve and usually characterized by ascending symmetrical weakness of upper lower extremities (Wijdicks & Klein, 2017). It rare condition worldwide frequency GBS only 2 in 100,000 adult individuals (McGrogan et al., 2009). Studies have shown its association with different vaccines but these pandemic times, there lack literature on post-COVID-19 vaccination-associated GBS. We report...
Guillain-Barré Syndrome (GBS) is a complex autoimmune disorder where person’s own immune system damages the nerve and usually characterized by ascending symmetrical weakness of upper lower extremities (Wijdicks & Klein, 2017). It rare condition worldwide frequency GBS only 2 in 100,000 adult individuals (McGrogan et al., 2009). Studies have shown its association with different vaccines but these pandemic times, there lack literature on post-COVID-19 vaccination-associated GBS. We...
Abstract BackgroundPreclinical and clinical studies indicate a role for MLC901 (NeuroAiD TM II) in Alzheimer’s Disease (AD). We investigated its safety efficacy as add-on therapy to standard treatment evaluated disease modifying effect mild moderate AD.MethodsMild-moderate probable AD patients by NINCDS-ADRDA criteria, stable on acetylcholinesterase inhibitors or memantine (n=125) were randomized receive (early starters) placebo (delayed 6 months, followed further months during which all...