A5079573229- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Renal function and acid-base balance
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Airway Management and Intubation Techniques
- Neonatal Respiratory Health Research
- Acute Kidney Injury Research
- Hemodynamic Monitoring and Therapy
- Long-Term Effects of COVID-19
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Image Processing Techniques and Applications
- Digital Holography and Microscopy
- Family and Patient Care in Intensive Care Units
- Cardiac, Anesthesia and Surgical Outcomes
- Non-Invasive Vital Sign Monitoring
- Cardiac Structural Anomalies and Repair
- Bone health and osteoporosis research
- Phonocardiography and Auscultation Techniques
- Thermal Regulation in Medicine
- Clinical Nutrition and Gastroenterology
- Blood Pressure and Hypertension Studies
National University Hospital
2015-2025
National University of Singapore
2015-2025
National University Health System
2010-2024
Medical Research Institute of New Zealand
2023
University of Auckland
2023
Middlemore Hospital
2023
Auckland City Hospital
2023
National Centre for Infectious Diseases
2021
University of Pittsburgh Medical Center
2012-2020
Medtronic (United States)
2020
To compare the acute effects of 0.9% saline versus a balanced electrolyte solution on kidney injury in rat model sepsis.Controlled laboratory experiment.University laboratory.Sixty adult, male Sprague-Dawley rats.We induced sepsis by cecal ligation and puncture randomized animals to receive fluid resuscitation with either or Plasma-Lyte for 4 hours after 18 (10 mL/kg first hour 5 next 3 hr). Blood urine specimens were obtained from baseline, puncture, immediately resuscitation, 24 later. We...
The efficacy of simvastatin in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.
Protocolized care bundles may improve patient by reducing medical errors, minimizing practice variability, and mortality. We hypothesized that the introduction of a multidisciplinary extubation protocol would reduce duration mechanical ventilation intensive unit length stay in tertiary cardiothoracic unit.A was created. The applied to all elective postoperative cardiac surgery patients. Data were collected 3 months before after initiation. Patients excluded if they experienced events...
Critically ill patients with acute respiratory distress syndrome and exacerbations of chronic obstructive pulmonary disease often develop hypercapnia require mechanical ventilation. Extracorporeal carbon dioxide removal can manage hypercarbia by removing directly from the bloodstream. Respiratory hemodialysis uses traditional to remove CO2 blood, mainly as bicarbonate. In this study, Stewart's approach acid-base chemistry was used create a dialysate that would maintain blood pH while well...
Patient-ventilator asynchrony (PVA) is associated with poor clinical outcomes and remains under-monitored. Automated PVA detection would enable complete monitoring standard observational methods do not allow. While model-based machine learning approaches exist, they have variable performance can miss specific events. This study compares a model rule-based algorithm method by retrospectively validating both using an independent patient cohort.
Abstract We aim to describe a case series of critically and non-critically ill COVID-19 patients in Singapore. This was multicentered prospective study with clinical laboratory details. Details for fifty uncomplicated ten who required mechanical ventilation were collected. compared features between the groups, assessed predictors intubation, described ventilatory management ICU patients. Ventilated significantly older, reported more dyspnea, had elevated C-reactive protein lactate...
Patient-ventilator asynchrony (PVA) is prevalent in mechanical ventilation (MV) for critically ill patients and has been associated with adverse patient outcomes. However, studies investigating the associations between PVA outcomes employ differing time windows evaluation. In this study, machine learning methods are used to quantify prevalence magnitude of at different windows, as well its temporal trends. The study aims identify optimal window assessing changes index (AI) (Masyn,avg). This...
Off-axis digital holographic microscopy is a high-throughput, label-free imaging technology that provides three-dimensional, high-resolution information about samples, which particularly useful in large-scale cellular imaging. However, the hologram reconstruction process poses significant bottleneck for timely data analysis. To address this challenge, we propose novel approach integrates deep learning with physical principles of off-axis holography. We initialized part network weights based...
Tocilizumab improves outcomes in critically ill patients with COVID-19. Whether other immune-modulator strategies are equally effective or better is unknown. We investigated treatment tocilizumab, sarilumab, anakinra and no immune modulator these patients. In this ongoing, adaptive platform trial 133 sites 9 countries, we randomly assigned allocation ratios dependent on the number of interventions available at each site. The primary outcome was an ordinal scale combining in-hospital...
Veno-arterial extra corporeal membrane oxygenation (VA-ECMO) is a modified heart lung machine used for patients with both and failure. This results in retrograde supply of oxygenated blood through the femoral artery which unsteady pulsating antegrade flow from aorta interacts steady, uniform, artery, creating mixing zone. work aims to provide mechanistic interpretation VA-ECMO by developing an in-silico framework using computational fluid dynamics. We performed several numerical simulations...
Evidence regarding the efficacy of high-flow nasal cannula (HFNC) oxygenation for preoxygenation and apnoeic is conflicting. Our objective to evaluate whether HFNC maintains higher oxygen saturation (SpO2) during rapid sequence intubation (RSI) in ED patients compared usual care.This was a multicentre, open-label, randomised controlled trial adult requiring RSI. Patients were randomly assigned 1:1 either intervention (HFNC at 60L/min) group or control (non-rebreather mask prongs least...
Lower tidal volume ventilation (targeting 3 mL/kg predicted body weight, PBW) facilitated by extracorporeal carbon dioxide removal (ECCO