A5079777621- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Iron Metabolism and Disorders
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Hemoglobinopathies and Related Disorders
- MicroRNA in disease regulation
- Dietary Effects on Health
- Cardiovascular Disease and Adiposity
- Muscle metabolism and nutrition
- Immune Cell Function and Interaction
- Regulation of Appetite and Obesity
- Nutritional Studies and Diet
- Neonatal Respiratory Health Research
- Cancer, Lipids, and Metabolism
- Nutrition and Health in Aging
- Infant Nutrition and Health
- Cancer-related molecular mechanisms research
- Fatty Acid Research and Health
- Lipid metabolism and disorders
- Growth Hormone and Insulin-like Growth Factors
- Sulfur Compounds in Biology
Institut d'Investigació Biomèdica de Girona
2016-2025
Instituto de Salud Carlos III
2016-2025
University of Girona
2016-2025
Hospital Universitari de Girona Doctor Josep Trueta
2012-2025
Centro de Investigación Biomédica en Red
2015-2024
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2009-2023
Clínica Girona
2015-2021
Centro Nacional de Microbiologia
2021
Central American Adventist University
2021
Instituto Venezolano de Investigaciones Científicas
2013
Context: Recently irisin (encoded by Fndc5 gene) has been reported to stimulate browning and uncoupling protein 1 expression in sc adipose tissue of mice. Objective: The objective the study was investigate FNDC5 gene human muscle circulating according obesity, insulin sensitivity, type 2 diabetes. Design, Patients, Main Outcome Measure: Adipose (ELISA) were analyzed different cohorts (n = 125 n 76); also evaluated a subcohort 34 subjects. In vitro studies preadipocytes adipocytes induced...
BACKGROUND Genomic studies have yielded important insights into the pathogenesis of obesity. Circulating microRNAs (miRNAs) are valuable biomarkers systemic diseases and potential therapeutic targets. We sought to define circulating pattern miRNAs in obesity examine changes after weight loss. METHODS assessed genomewide miRNA profile cross-sectionally 32 men surgery-induced loss 6 morbidly obese patients. The most relevant were validated 80 longitudinally 22 patients (after loss). evaluated...
Background Potential regulators of adipogenesis include microRNAs (miRNAs), small non-coding RNAs that have been recently shown related to adiposity and differentially expressed in fat depots. However, date no study is available, our knowledge, regarding miRNAs expression profile during human adipogenesis. Thereby, the aim this was investigate whether miRNA pattern cells subcutaneous adipose tissue associated obesity co-morbidities adipocytes linked Methodology/Principal Findings We...
OBJECTIVEThis study sought to identify the profile of circulating microRNAs (miRNAs) in type 2 diabetes (T2D) and its response changes insulin sensitivity.
Zonulin is the only physiological mediator known to regulate intestinal permeability reversibly by modulating intercellular tight junctions. To investigate relationship between and obesity-associated metabolic disturbances in humans, we aimed study circulating zonulin according obesity insulin resistance. Circulating (ELISA) was measured 123 caucasian men association with inflammatory parameters (including minimal model-measured sensitivity). increased body mass index (BMI), waist hip ratio...
Abstract Context: Circulating microRNAs (miRNAs) are valuable biomarkers of metabolic diseases and potential therapeutic targets in this field. Objective: Our objective was to define the circulating pattern miRNAs childhood obesity. Design, Settings, Main Outcome Measure: The genome-wide miRNA profile assessed by RT-PCR 10 boys (5 lean 5 obese children). most relevant were cross-sectionally validated 85 versus 40 children (63 62 girls) longitudinally evaluated samples from same when they ∼7...
The microbiota-gut-brain axis has emerged as a novel target in depression, disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not addressing microbiome functionality, compositional nature, or confounding factors. We applied multi-omics approach combining pre-clinical models three human cohorts including patients mild depression. Microbial functions and metabolites converging onto glutamate/GABA metabolism, particularly...
Growing evidence implicates the gut microbiome in cognition. Viruses, most abundant life entities on planet, are a commonly overlooked component of virome, dominated by Caudovirales and Microviridae bacteriophages. Here, we show discovery (n = 114) validation cohort 942) that subjects with increased Siphoviridae levels had better performance executive processes verbal memory. Conversely, were linked to greater impairment abilities. Microbiota transplantation from human donors specific (>90%...
Bone has recently been described as exhibiting properties of an endocrine organ by producing osteocalcin that increases insulin sensitivity and secretion in animal models.We aimed to evaluate circulating association with three different studies nondiabetic subjects: one cross-sectional study 149 men (using minimal model), two longitudinal independent groups (one formed 26 women, the other 9 11 women), after a mean 7.3 16.8% weight loss, 8.7% loss plus regular exercise.In study, was...
Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance obesity. We aimed to study the effects of weight loss-induced improved sensitivity on circulating omentin concentrations.Circulating omentin-1 (ELISA) concentration association metabolic variables was measured 35 obese subjects (18 men, 17 women) before after hypocaloric loss.Baseline concentrations correlated BMI (r = -0.58, p < 0.001), body -0.35, 0.045), fat mass -0.67,...
GPR55 is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) its only known endogenous ligand. We investigated 1) whether expressed in fat liver; 2) the correlation of both LPI with several metabolic parameters; 3) actions on human adipocytes. analyzed CB1, CB2, gene expression circulating levels two independent cohorts obese lean subjects, normal or impaired glucose tolerance type 2 diabetes. Ex vivo experiments were used to measure intracellular calcium lipid...
Objective: Although increased central fat mass is characteristic of active Cushing's syndrome (CS), little known about body composition and secretion adipokines after long-term recovery CS. The aim this study was to evaluate its correlation with cardiovascular risk factors in patients remission
The canonical view about the effect of thyroid hormones (THs) on thermogenesis assumes that hypothalamus acts merely as a modulator sympathetic outflow brown adipose tissue (BAT). Recent data have challenged vision by demonstrating THs act ventromedial nucleus (VMH) to inhibit AMP-activated protein kinase (AMPK), which regulates thermogenic program in BAT, leading increased and weight loss. Current shown addition activation fat, browning white (WAT) might also be an important mechanism....
Omentin is a novel soluble lectin expressed mainly in the stromal-vascular cells from visceral adipose tissue with vasodilator effect isolated blood vessels. To gain insight relationship between obesity and cardiovascular risk factors, we aimed to explore interaction among circulating omentin, metabolic parameters, endothelial function. Circulating omentin (enzyme-linked immunosorbent assay) was studied 248 white men (148 normal glucose tolerance (NGT) 100 impaired (IGT)). Insulin...
The relevance of microRNAs (miRNAs) in adipose tissue is increasingly recognized, being intrinsically linked to different pathways, including obesity-related inflammation. In this study, we aimed characterize the changes induced by inflammation on miRNA pattern human adipocytes and macrophages. Therefore, an extensive profile 754 common miRNAs was assessed cells (human primary mature adipocytes, macrophage-like cell line THP-1) their supernatants (SN) using TaqMan low-density arrays. These...