A5004234488- Insect symbiosis and bacterial influences
- Gut microbiota and health
- Evolution and Genetic Dynamics
- Cardiovascular Syncope and Autonomic Disorders
- Insect-Plant Interactions and Control
- Plant Virus Research Studies
- Genomics and Phylogenetic Studies
- Cardiac Arrhythmias and Treatments
- Plant and animal studies
- Clostridium difficile and Clostridium perfringens research
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Mathematical and Theoretical Epidemiology and Ecology Models
- Microbial Community Ecology and Physiology
- Insect and Arachnid Ecology and Behavior
- Insect and Pesticide Research
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Genetic diversity and population structure
- Probiotics and Fermented Foods
- Entomopathogenic Microorganisms in Pest Control
- Bacteriophages and microbial interactions
- Hepatitis B Virus Studies
- Insect Resistance and Genetics
- Insect behavior and control techniques
Universitat de València
2016-2025
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2016-2025
Institute for Integrative Systems Biology
2014-2025
Consejo Superior de Investigaciones Científicas
2003-2025
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2016-2025
Centre for Biomedical Network Research on Rare Diseases
2015-2025
Federico Santa María Technical University
2025
Hospital Universitario Dexeus
2015-2024
Centro de Investigación Biomédica en Red
2008-2024
Universidad Politécnica de Madrid
2024
The ESC Guidelines represent the views of and were arrived at after careful consideration available evidence time they written.Health professionals are encouraged to take them fully into account when exercising their clinical judgement.The guidelines do not, however, override individual responsibility health make appropriate decisions in circumstances patients, consultation with that patient, where necessary patient's guardian or carer.It is also professional's verify rules regulations...
Neurally-mediated (reflex)Vasovagal syncope (common faint)e classical e non-classical Carotid sinus Situational acute haemorrhage cough, sneeze gastrointestinal stimulation (swallow, defaecation, visceral pain) micturition (post-micturition) post-exercise post-prandial others (e.g., brass instrument playing, weightlifting) Glossopharyngeal neuralgia Orthostatic hypotension Autonomic failure primary autonomic syndromes pure failure, multiple system atrophy, Parkinson's disease with failure)...
Little is known about the mutational fitness effects associated with single-nucleotide substitutions on RNA viral genomes. Here, we used site-directed mutagenesis to create 91 single mutant clones of vesicular stomatitis virus derived from a common ancestral cDNA and performed competition experiments measure relative each mutant. The distribution nonlethal deleterious was highly skewed had long, flat tail. As expected, depended whether mutations were chosen at random or reproduced previously...
Recurrent hepatitis occurs in the majority of patients undergoing liver transplantation for C virus (HCV) cirrhosis, with progression to cirrhosis up 30% after 5 years. Based on these data, a decrease survival can be anticipated prolonged follow-up. Furthermore, posttransplantation HCV-fibrosis has been shown recent years increase. Our aims were (1) describe natural history HCV-infected recipients, particularly determine whether decreased years; (2) compare this outcome that observed...
Guidelines and Expert Consensus documents aim to present all the relevant evidence on a particular issue in order help physicians weigh benefits risks of diagnostic or therapeutic procedure.They should be helpful everyday clinical decisionmaking.A great number Documents have been issued recent years by European Society Cardiology (ESC) different organisations other related societies.This profusion can put at stake authority validity guidelines, which only guaranteed if they developed an...
<h3>Objective</h3> Antibiotic (AB) usage strongly affects microbial intestinal metabolism and thereby impacts human health. Understanding this process the underlying mechanisms remains a major research goal. Accordingly, we conducted first comparative omic investigation of gut communities in faecal samples taken at multiple time points from an individual subjected to β-lactam therapy. <h3>Methods</h3> The total (16S rDNA) active rRNA) microbiota, metagenome, metatranscriptome (mRNAs),...
We have sequenced the genome of intracellular symbiont Buchnera aphidicola from aphid Baizongia pistacea . This strain diverged 80–150 million years ago common ancestor two previously strains. Here, a field-collected, nonclonal sample insects was used as source material for laboratory procedures. As consequence, assembly unveiled intrapopulational variation, consisting ≈1,200 polymorphic sites. Comparison 618-kb (kbp) with other genomes revealed nearly perfect gene-order conservation,...
Recenzentów dokumentu z ramienia Komisji ESC ds. Wytycznych Postępowania (CPG) oraz ze strony narodowych towarzystw kardiologicznych wchodzących w skład
Abstract Background Recent genomic analyses of arthropod defense mechanisms suggest conservation key elements underlying responses to pathogens, parasites and stresses. At the center pathogen-induced immune are signaling pathways triggered by recognition fungal, bacterial viral signatures. These result in production response molecules, such as antimicrobial peptides lysozymes, which degrade or destroy invaders. Using recently sequenced genome pea aphid ( Acyrthosiphon pisum ), we conducted...
Shivering Viromes Despite its icy reputation, freshwater ponds and lakes do occur in Antarctica, open can be found for a few brief weeks during the austral summer. The ecology of these is, as expected, rather specialized to cope with extreme seasonal conditions. In metagenomic study, López-Bueno et al. (p. 858 ) inspected virus community Lake Limnopolar on Livingston Island an unexpectedly rich genetic diversity. A dominant group previously unidentified single-stranded DNA viruses was found,...
Background— The efficacy of cardiac pacing for prevention syncopal recurrences in patients with neurally mediated syncope is controversial. We wanted to determine whether therapy reduces severe asystolic syncope. Methods and Results— Double-blind, randomized placebo-controlled study conducted 29 centers the Third International Study on Syncope Uncertain Etiology (ISSUE-3) trial. Patients were ≥40 years, had experienced ≥3 episodes previous 2 years. Initially, 511 patients, received an...
We have studied 15 gene loci coding for enzymes in 121 Trypanosoma cruzi stocks from a wide geographic range--from the United States and Mexico to Chile southern Brazil. T. is diploid but reproduction basically clonal, with very little if any sexuality remaining at present. identified 43 different clones by their genetic composition; same clone often found distant places diverse hosts. There much heterogeneity among clones, they cannot be readily classified into few discrete groups that...
Background —This study was performed to compare implantation of a DDI pacemaker with rate hysteresis no implant in respect syncopal recurrences patients severe cardioinhibitory tilt-positive neurally mediated syncope. Methods and Results —Forty-two from 18 European centers were randomized receive programmed 80 bpm 45 (19 patients) or (23 patients). Inclusion criteria ≥3 syncopes over the last 2 years positive (Vasovagal Syncope International Study types 2A 2B) response tilt testing. The...
This prospective multicentre observational study assessed the efficacy of specific therapy based on implantable loop recorder (ILR) diagnostic observations in patients with recurrent suspected neurally mediated syncope (NMS).Patients three or more clinically severe syncopal episodes last 2 years without significant electrocardiographic and cardiac abnormalities were included. Orthostatic hypotension carotid sinus excluded. After ILR implantation, followed until first documented (Phase I)....
The human gut is the natural habitat for a large and dynamic bacterial community that has great relevance health. Metagenomics increasing our knowledge of gene content as well functional genetic variability in this microbiome. However, little known about active bacteria their function(s) gastrointestinal tract. We performed metatranscriptomic study on ten healthy volunteers to elucidate members microbiome functionality under conditions First, microbial cDNAs obtained from each sample were...
This article introduces the second release of Gypsy Database Mobile Genetic Elements (GyDB 2.0): a research project devoted to evolutionary dynamics viruses and transposable elements based on their phylogenetic classification (per lineage protein domain). The (GyDB) is long-term that continuously progressing, owing high molecular diversity mobile requires be completed in several stages. GyDB 2.0 has been powered with wiki allow other researchers participate project. current database stage...
Culture-dependent methods have shown that meconium, the newborn's first intestinal discharge, is not sterile, but diversity of bacteria present in this material needs to be further characterized by means more sensitive molecular techniques.Our aims were characterize molecularly meconium microbiota term infants, assess whether it contributes future infants' gastrointestinal tract, and evaluate how relates lifestyle variables atopy-related conditions.We applied high-throughput pyrosequencing...
Intracellular bacteria are characterized by genome reduction. The 422,434-base pair of Buchnera aphidicola BCc, primary endosymbiont the aphid Cinara cedri, is approximately 200 kilobases smaller than previously sequenced B. genomes. BCc has lost most metabolic functions, including ability to synthesize essential amino acid tryptophan and riboflavin. In addition, retained genes evolving rapidly. Possibly, losing its symbiotic capacity being complemented (and might be replaced) highly...