A5007880285- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Diabetes and associated disorders
- Iron Metabolism and Disorders
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Growth Hormone and Insulin-like Growth Factors
- Health and Lifestyle Studies
- Hemoglobinopathies and Related Disorders
- Pituitary Gland Disorders and Treatments
- Lipid metabolism and disorders
- Gestational Diabetes Research and Management
- Cardiovascular Disease and Adiposity
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neonatal Respiratory Health Research
- Diabetes Management and Research
- Bariatric Surgery and Outcomes
- Peroxisome Proliferator-Activated Receptors
- Thyroid Disorders and Treatments
- MicroRNA in disease regulation
- Blood Pressure and Hypertension Studies
Institut d'Investigació Biomèdica de Girona
2015-2024
Centro de Investigación Biomédica en Red
2015-2024
Instituto de Salud Carlos III
2015-2024
Universitat de Girona
2001-2024
Hospital Universitari de Girona Doctor Josep Trueta
2008-2023
Government of Catalonia
2016-2022
Institut Català de la Salut
2016-2022
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2009-2021
Centro Nacional de Microbiologia
2021
Clínica Girona
2000-2021
Context: Recently irisin (encoded by Fndc5 gene) has been reported to stimulate browning and uncoupling protein 1 expression in sc adipose tissue of mice. Objective: The objective the study was investigate FNDC5 gene human muscle circulating according obesity, insulin sensitivity, type 2 diabetes. Design, Patients, Main Outcome Measure: Adipose (ELISA) were analyzed different cohorts (n = 125 n 76); also evaluated a subcohort 34 subjects. In vitro studies preadipocytes adipocytes induced...
There is increasing evidence that systemic inflammation and insulin resistance constitute interrelated events contribute to atherosclerosis. We studied the effect of association between circulating interleukin 6 (IL-6) levels, one major mediators inflammation, C-reactive protein on blood pressure in 228 healthy volunteers. The plasma IL-6 concentration was significantly similarly associated with systolic (SBP) diastolic (DBP) pressure, fasting insulin, index (FIRI) all subjects. When smokers...
BACKGROUND Genomic studies have yielded important insights into the pathogenesis of obesity. Circulating microRNAs (miRNAs) are valuable biomarkers systemic diseases and potential therapeutic targets. We sought to define circulating pattern miRNAs in obesity examine changes after weight loss. METHODS assessed genomewide miRNA profile cross-sectionally 32 men surgery-induced loss 6 morbidly obese patients. The most relevant were validated 80 longitudinally 22 patients (after loss). evaluated...
Background Potential regulators of adipogenesis include microRNAs (miRNAs), small non-coding RNAs that have been recently shown related to adiposity and differentially expressed in fat depots. However, date no study is available, our knowledge, regarding miRNAs expression profile during human adipogenesis. Thereby, the aim this was investigate whether miRNA pattern cells subcutaneous adipose tissue associated obesity co-morbidities adipocytes linked Methodology/Principal Findings We...
OBJECTIVEThis study sought to identify the profile of circulating microRNAs (miRNAs) in type 2 diabetes (T2D) and its response changes insulin sensitivity.
Zonulin is the only physiological mediator known to regulate intestinal permeability reversibly by modulating intercellular tight junctions. To investigate relationship between and obesity-associated metabolic disturbances in humans, we aimed study circulating zonulin according obesity insulin resistance. Circulating (ELISA) was measured 123 caucasian men association with inflammatory parameters (including minimal model-measured sensitivity). increased body mass index (BMI), waist hip ratio...
Abstract The human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes normal physiology disease susceptibility. Here, the microbiota (mycobiome) in obese non-obese subjects was characterized using Internal Transcribed Spacer (ITS)-based sequencing. results demonstrate patients could be discriminated by their specific composition, which also distinguished metabolically “healthy” from “unhealthy” obesity. Clusters according...
Abstract Context: Circulating microRNAs (miRNAs) are valuable biomarkers of metabolic diseases and potential therapeutic targets in this field. Objective: Our objective was to define the circulating pattern miRNAs childhood obesity. Design, Settings, Main Outcome Measure: The genome-wide miRNA profile assessed by RT-PCR 10 boys (5 lean 5 obese children). most relevant were cross-sectionally validated 85 versus 40 children (63 62 girls) longitudinally evaluated samples from same when they ∼7...
The microbiota-gut-brain axis has emerged as a novel target in depression, disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not addressing microbiome functionality, compositional nature, or confounding factors. We applied multi-omics approach combining pre-clinical models three human cohorts including patients mild depression. Microbial functions and metabolites converging onto glutamate/GABA metabolism, particularly...
Growing evidence implicates the gut microbiome in cognition. Viruses, most abundant life entities on planet, are a commonly overlooked component of virome, dominated by Caudovirales and Microviridae bacteriophages. Here, we show discovery (n = 114) validation cohort 942) that subjects with increased Siphoviridae levels had better performance executive processes verbal memory. Conversely, were linked to greater impairment abilities. Microbiota transplantation from human donors specific (>90%...
Iron-related insulin-resistance is improved by iron depletion or treatment with chelators. The aim of this study was to evaluate insulin sensitivity and secretion after blood letting in patients who had high-ferritin type 2 diabetes were randomized (three phlebotomies [500 ml blood] at 2-week intervals, group 1) observation (group 2). Insulin tested baseline 4 12 months thereafter. two groups matched for age, BMI, pharmacologic treatment, chronic diabetic complications. All negative C282Y...
OBJECTIVE In epidemiological studies, serum ferritin was the second-strongest determinant of blood glucose (after BMI) in regression models and third-strongest insulin BMI age). Its concentration also correlated positively with plasma triglycerides apolipoprotein B concentrations, negatively HDL2 cholesterol. We hypothesized that could be a marker resistance. RESEARCH DESIGN AND METHODS Oral tolerance sensitivity (SI, minimal model method) were prospectively evaluated 36 healthy subjects....
Bone has recently been described as exhibiting properties of an endocrine organ by producing osteocalcin that increases insulin sensitivity and secretion in animal models.We aimed to evaluate circulating association with three different studies nondiabetic subjects: one cross-sectional study 149 men (using minimal model), two longitudinal independent groups (one formed 26 women, the other 9 11 women), after a mean 7.3 16.8% weight loss, 8.7% loss plus regular exercise.In study, was...
Type 2 diabetes and the insulin resistance syndrome have been hypothesized to constitute manifestations of an ongoing acute-phase response. We aimed study interleukin-6 (IL-6) gene polymorphism in relation sensitivity (IL-6 is main cytokine involved response). Subjects homozygous for C allele at position -174 IL-6 (SfaNI genotype), associated lower plasma levels, showed significantly integrated area under curve serum glucose concentrations (AUCglucose) after oral tolerance test, blood...
Tumor necrosis factor-α (TNF-α), acting as a modulator of gene expression in adipocytes, is implicated the development insulin resistance and obesity. The aim this study was to investigate whether Nco I polymorphism TNF-a influences relationship among resistance, percent body fat, serum leptin levels. A sample 38 subjects (19 men, mean age 36.2 ± 1.9 years, BMI 28.8 1.2 kg/m2, range 22.2–35.7; 19 women, 34.9 1.4 28.1 0.8 19–37.9) divided into two groups on basis genotype. Twenty-three were...
Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance obesity. We aimed to study the effects of weight loss-induced improved sensitivity on circulating omentin concentrations.Circulating omentin-1 (ELISA) concentration association metabolic variables was measured 35 obese subjects (18 men, 17 women) before after hypocaloric loss.Baseline concentrations correlated BMI (r = -0.58, p < 0.001), body -0.35, 0.045), fat mass -0.67,...
Recent studies have shown that the tumor necrosis factor (TNF) system is implicated in insulin resistance of human obesity. Plasma concentrations soluble fraction TNF receptors 1 and 2 (sTNFR1 sTNFR2) are thought to reflect degree activation system. The purpose this study was explore whether activation, as measured by levels circulating sTNFR1 sTNFR2, associated with resistance. A total 19 men (mean age 36.2 +/- 1.9; BMI 28.8 1.2, range 22.2-35.7) 17 premenopausal women (age 34.9 1.4; 28.1...
Visfatin has shown to be increased in type 2 diabetes but unrelated insulin sensitivity. We hypothesized that visfatin is associated with secretion humans. To this aim, a cross-sectional study was conducted 118 nondiabetic men and 64 (35 29 women) diabetic patients. Type 1 patients long-standing disease (n = 58; 31 27 were also studied. In subjects, circulating (enzyme immunoassay) independently (acute response glucose [AIRg] from intravenous tolerance tests) not sensitivity (Si) or other...
Several lines of evidence indicate that interleukin-6 (IL-6) is involved not only in the hepatic acute phase response but also adipose tissue metabolism, lipoprotein lipase activity, and triglyceride secretion.A polymorphism IL-6 gene, associated with differences transcription rate, has been recently described.We aimed to study whether this gene leads fasting postglucose load plasma lipids healthy subjects.Subjects G at position Ϫ174 were similar age, sex, body mass index, waist hip ratio...