A5028397739- Hormonal Regulation and Hypertension
- Paraoxonase enzyme and polymorphisms
- Proteoglycans and glycosaminoglycans research
- Apelin-related biomedical research
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- COVID-19 Clinical Research Studies
- Acute Kidney Injury Research
- Pomegranate: compositions and health benefits
- Long-Term Effects of COVID-19
- Organ Transplantation Techniques and Outcomes
- Blood Pressure and Hypertension Studies
- Lipid metabolism and biosynthesis
- Renal and Vascular Pathologies
- Chronic Kidney Disease and Diabetes
- Mesenchymal stem cell research
- Natural Antidiabetic Agents Studies
- Congenital Heart Disease Studies
- Cynara cardunculus studies
- Cardiac Ischemia and Reperfusion
- Renin-Angiotensin System Studies
- Liver physiology and pathology
- Vascular anomalies and interventions
- SARS-CoV-2 and COVID-19 Research
Rambam Health Care Campus
2013-2024
Technion – Israel Institute of Technology
2003-2022
Hanyang University
2022
Tongji University
2022
Tongji Hospital
2022
Rappaport Family Institute for Research in the Medical Sciences
2003-2018
Meyer Children's Hospital
2003
The renin-angiotensin-aldosterone system is involved in the pathogenesis of atherosclerosis, partially because its pro-oxidative properties. We questioned effect and mechanisms action administration aldosterone to apolipoprotein E-deficient (E(0)) mice on their macrophages aorta oxidative status ability pharmacological agents block this effect.Aldosterone (0.2 6 microg. mouse(-1) x d(-1)) was administered E(0) alone or combination with eplerenone (200 mg kg(-1) d(-1)), ramipril (5 losartan...
Aldosterone plays an important role in the pathophysiology of congestive heart failure (CHF), and spironolactone improves cardiovascular function survival rates patients with CHF. We hypothesized that mineralocorticoid receptor blockade (MRB) exerted its beneficial effects by reducing oxidative stress changing balance between counter-acting enzymes angiotensin-converting enzyme (ACE) ACE2. Monocyte-derived macrophages were obtained from 10 CHF before after 1 month treatment (25 mg/d)....
Oxidative stress is involved in the pathogenesis of atherosclerosis, and angiotensin II (AT-II) induces oxidative enhances atherogenesis. Aldosterone, which has an important role pathology heart failure, recently been implicated as a mediator AT-II biologic activities. In this study, we analyzed whether administration selective aldosterone blocker eplerenone to atherosclerotic apolipoprotein E–deficient (E0) mice would affect their status Apolipoprotein were administered chow containing (200...
Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, it may induce chronic damage by activating epithelial to mesenchymal transition (EMT) tubular cells. Heparanase (HPSE), endoglycosidase that regulates FGF-2 TGFβ-induced EMT, have role. Therefore, aim this study was evaluate its role in the I/R-induced pro-fibrotic machinery employing vitro vivo models.Wild type (WT) HPSE-silenced cells were subjected hypoxia reoxygenation presence or absence...
Abstract Despite intensive efforts, there is no effective remedy for COVID‐19. Moreover, vaccination efficacy declines over time and may be compromised against new SARS‐CoV‐2 lineages. Therefore, remains an unmet need simple, accessible, low‐cost pharmacological anti‐SARS‐CoV‐2 agents. ArtemiC a medical product comprising artemisinin, curcumin, frankincense vitamin C, all of which possess anti‐inflammatory anti‐oxidant properties. The present Phase II placebo‐controlled, double‐blinded,...
// Zaid Abassi 1,2 , Shadi Hamoud 3 Ahmad Hassan 4 Iyad Khamaysi 5 Omri Nativ 1 Samuel N. Heyman 6 Rabia Shekh Muhammad Neta Ilan 7 Preeti Singh Edward Hammond 8 Gianluigi Zaza 9 Antonio Lupo Maurizio Onisto 10 Gloria Bellin Valentina Masola Israel Vlodavsky and Giovani Gambaro 11 Department of Physiology, The Rappaport Faculty Medicine, Technion, Haifa, 2 Laboratory Rambam Health Care Campus, Internal Medicine E, A, Gastroenterology, Hebrew University-Hadassah Medical Center, Jerusalem,...
Objective— The role of insulin in atherosclerosis progression diabetes is uncertain. We examined the effects oral supplementation on atherogenesis apolipoprotein E-deficient (E 0 ) mice. Methods and Results— One-month-old male E mice were orally supplemented with human (0.1, 0.5, 1 U/mL) or placebo for 3 months. At end study, serum macrophage oxidative stress studied. Insulin reduced lesion size by 22% to 37% ( P <0.05) all study groups. Lipid peroxides levels 18% lower <0.01),...
Acute kidney injury (AKI) is a serious health concern with high morbidity and mortality worldwide. Recently, sexual dimorphism has become increasingly recognized as factor influencing the severity of disease. This study explores gender-specific renoprotective pathways in αMUPA transgenic mice subjected to AKI. male female were ischemia-reperfusion (I/R)-AKI presence or absence orchiectomy, oophorectomy, L-NAME administration. Blood samples kidneys harvested 48 h following AKI for biomarkers...
Background: The Departments of emergency medicine provide services and immediate medical responses to patients admitted with different levels acute emergencies. Critically ill subjects are managed in the &quot;Shock Room&quot;, which life-saving interventions apply. In such patients, time diagnosis initiation treatment critical prognostic factors that directly affect chance surviving event. aim this study was assess predictors survival hospitalized following shock room a tertiary...
Abstract Whereas atherogenicity of dietary lipids has been largely studied, relatively little is known about the possible contribution amino acids to macrophage foam‐cell formation, a hallmark early atherogenesis. Recently, we showed that leucine antiatherogenic properties in model system. In this study, an in‐depth investigation role lipid metabolism was conducted by supplementing humans, mice, or cultured macrophages with leucine. Macrophage incubation serum obtained from healthy adults...
Atherosclerosis is a complex disease involving different cell types, including macrophages that play major role in the inflammatory events occurring atherogenesis. C-Reactive Protein (CRP) sensitive systemic marker of inflammation and was identified as biomarker cardiovascular diseases. Histological studies demonstrate CRP presence human atherosclerotic lesions, we have previously shown express mRNA. could be locally secreted lesion by arterial local regulation affect its pro-atherogenic...
Atherosclerosis is a multifactorial process. Emerging evidence highlights role of the enzyme heparanase in various disease states, including atherosclerosis formation and progression.The aim study was to investigate effect inhibition on blood pressure, glucose levels, oxidative stress apoE-/- mice.Male mice were divided into two groups: one treated by inhibitor PG545, administered intraperitoneally weekly for seven weeks, other serving as control group (injected with saline). Blood pressure...
For more than a year, health systems all over the world have been combating global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2). The was first described in city of Wuhan China, presenting as an atypical infection lower tract.COVID-19 is characterized multisystemic involvement, and mortality attributed mainly to system which may lead distress failure. Several COVID-19-associated complications are being increasingly reported,...
Background- Angiotensin II, produced by angiotensin-converting-enzyme (ACE), enhances oxidative stress and atherogenesis. In this study, we analyzed whether tissue ACE deficiency in ACE-knockout mice type-2 would affect their status. Moreover, crossbreeding the with atherosclerotic apolipoprotein E (apo E)-deficient (E0) mice, questioned affects atherogenesis.ACE-deficient (ACE+/-) exhibited reduced serum lipid peroxidation compared ACE+/+ mice. Peritoneal macrophages from ACE+/-...
Na+/H+ exchangers (NHEs), encoded by Solute Carrier 9A (SLC9A) genes in human, are ubiquitous integral membrane ion transporters that mediate the electroneutral exchange of H+ with Na+ or K+. NHEs, found kidney and intestine, play a major role process fluid reabsorption together via Na+,K+-ATPase pump channels. Nevertheless, expression pattern NHE lung its alveolar homeostasis has not been addressed. Therefore, we aimed to examine specific isoforms epithelial cells (AECs), assess their...
Congestive heart failure (CHF) is often associated with impaired kidney function. Over- activation of the renin-angiotensin-aldosterone system (RAAS) contributes to avid salt/water retention and cardiac hypertrophy in CHF. While deleterious effects angiotensin II (Ang II) CHF are well established, biological actions 1-7 1-7) not fully characterized. In this study, we assessed acute Ang (0.3, 3, 30 300 ng/kg/min, IV) on urinary flow (UF), Na+ excretion (UNaV), glomerular filtration rate (GFR)...
Oxidative stress is an important risk factor in the pathogenesis of atherosclerosis. Angiotensin-converting enzyme (ACE) inhibitors attenuate atherosclerosis and oxidative animal models. Omapatrilat, a VasoPeptidase-inhibitor, selectively inhibits both Neutral-Endo-Peptidase (NEP) ACE.In this study, we analyzed effect Omapatrilat administration (1, 4, or 20mg/kg/d, for 12 weeks) to atherosclerotic apolipoprotein E-deficient (E0) mice on their blood pressure (BP), serum macrophage status,...
Background: There are no data regarding the effects of conventional therapies or dietary antioxidants in hypercholesterolemic diabetic patients, on their lipid and oxidative stress-related daily rhythms. Objective: To investigate Pomegranate Extract (POMx), simvastatin metformin patients rhythms serum lipids stress, macrophage atherogenicity. Methods: Three healthy subjects, three two participated current pilot study. Blood samples were collected around clock from same patient (every 4 h...