A5035036076- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- Blood Pressure and Hypertension Studies
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Genetic Associations and Epidemiology
- Organ Donation and Transplantation
- Hormonal Regulation and Hypertension
- Hemodynamic Monitoring and Therapy
- Birth, Development, and Health
- Parathyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Hormonal and reproductive studies
- Central Venous Catheters and Hemodialysis
- Renal and related cancers
- Sexual Differentiation and Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Folate and B Vitamins Research
- Body Composition Measurement Techniques
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
Molecular Medicine Ireland
2025
Royal College of Surgeons in Ireland
2017-2024
Beaumont Hospital
2015-2024
Botsford Hospital
2018
Beaumont Hospital, Dearborn
2018
Tallaght University Hospital
2017
Trinity College Dublin
2017
Framingham Heart Study
2010-2013
Harvard University
2010-2013
Brigham and Women's Hospital
2010-2013
Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but associations these single nucleotide polymorphisms (SNPs) incident CKD or ESRD are unknown. We thus investigated with 26,308 individuals European ancestry free at baseline drawn from eight population-based cohorts followed median 7.2 years (including 2,122 cases defined as <60ml/min/1.73m2...
Kidney transplant survival benefits are not observed for around 8 months after transplantation because of a higher complications rate in early post-transplant periods. This study compares patients awaiting with recipients and non-listed dialysis Ireland.In this retrospective analysis, the relative-risk (RR) death was assessed time-dependent, non-proportional hazards adjustment age, cause end-stage kidney disease (ESKD), time from first treatment ESKD to placement on waiting list year initial...
Galectin-3, a profibrotic mediator, is linked to the development of renal fibrosis in animal models and inversely correlates with GFR humans, but whether galectin-3 predicts incident kidney disease unknown. Here, we assessed outcomes for 2450 Framingham Offspring participants who attended examination 6 (1995-1998) had follow-up data at 8 (2005-2008). Renal interest included rapid decline function (≥3 ml/min per 1.73 m(2) year estimated [eGFR]), CKD (eGFR < 60 m(2)), albuminuria...
Background and objectives An environmental trigger has been proposed as an inciting factor in the development of anti-GBM disease. This multicenter, observational study sought to define national incidence disease during 11-year period (2003–2014) Ireland, investigate clustering cases time space, assess effect spatial variability on outcome. Design, setting, participants, & measurements We ascertained by screening immunology laboratories for instances positivity antibody renal...
Background. Elevations in serum phosphorus are associated with renal decline animal models and progression of established chronic kidney disease (CKD) human observational studies. We examined whether levels increase the risk incident CKD or end-stage (ESRD) two population-based prospective cohort
Serum calcium levels are tightly regulated. We performed genome-wide association studies (GWAS) in population-based participating the CHARGE Consortium to uncover common genetic variations associated with total serum levels. GWAS of concentrations was 20 611 individuals European ancestry for ∼2.5 million genotyped and imputed single-nucleotide polymorphisms (SNPs). The SNP lowest P-value rs17251221 (P = 2.4 * 10(-22), minor allele frequency 14%) calcium-sensing receptor gene (CASR). This...
Background Impaired blood pressure (BP) stabilisation after standing, defined using beat-to-beat measurements, has been shown to predict important health outcomes. We aimed define the relationship between individual classes of antihypertensive agent and BP among hypertensive older adults. Methods Cross-sectional analysis from The Irish Longitudinal Study on Ageing, a cohort study adults aged 50 years over. Beat-to-beat was recorded in participants undergoing an active stand test. grade 1...
Whether novel biomarkers improve the assessment of incident kidney disease and related adverse outcomes remains to be tested in longitudinal observational studies. We 14 urinary for association with kidney, cardiovascular, mortality 2948 Framingham Heart Study participants. Baseline examinations were performed between 1995 1998; mean follow-up was 10.1 years renal 11.2 survival analyses. Primary CKD, albuminuria, cardiovascular disease, all-cause mortality. Secondary analyses assessed...
In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure kidney function, we developed strategy for integrating prior knowledge into existing GWAS data eGFR from CKDGen Consortium. Our focuses on single nucleotide polymorphism (SNPs) in genes that are connected by functional evidence,...
Chronic kidney disease is a major worldwide public health problem that causes substantial morbidity and mortality. Studies from the Asia-Pacific region have reported some of highest chronic prevalence rates in world, but access to dialysis limited many countries, making it imperative identify high-risk individuals. We performed participant-level data overview prospective studies conducted quantify magnitude direction associations between putative risk factors renal death. Age- sex-adjusted...
Kidney grafts from donors who died of stroke and related traits have worse outcomes relative to both living those other causes. We hypothesise that deceased donors, particularly stroke, elevated polygenic burden for cerebrovascular traits. further this donor is associated with inferior graft in the recipient.
Albuminuria and reduced glomerular filtration rate are manifestations of chronic kidney disease (CKD) that predict end-stage renal disease, acute injury, cardiovascular death. We hypothesized SNPs identified in association with the estimated (eGFR) would also be associated albuminuria. Within CKDGen Consortium cohort (n= 31 580, European ancestry), we tested 16 eGFR-associated for urinary albumin-to-creatinine ratio (UACR) albuminuria [UACR >25 mg/g (women); 17 (men)]. In parallel, within...