A5038318320- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Renal Diseases and Glomerulopathies
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Healthcare Policy and Management
- Primary Care and Health Outcomes
- Health Policy Implementation Science
- Gastric Cancer Management and Outcomes
- Systemic Lupus Erythematosus Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Aldose Reductase and Taurine
- Inflammatory mediators and NSAID effects
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Chronic Kidney Disease and Diabetes
- Atherosclerosis and Cardiovascular Diseases
- Psoriasis: Treatment and Pathogenesis
- Nanocluster Synthesis and Applications
- Telomeres, Telomerase, and Senescence
- Nausea and vomiting management
Kunming Medical University
2011-2024
Xi'an Jiaotong University
2024
Nanjing University of Aeronautics and Astronautics
2023
Roche (Canada)
2022-2023
Second Affiliated Hospital of Nanchang University
2020-2021
Nanchang University
2020-2021
Hospital for Sick Children
2016-2021
Public Health Ontario
2021
University of Toronto
2007-2021
Xinqiao Hospital
2014-2016
Significance Statement Although studies show that diabetic kidney disease has a heritable component, searches for the genetic determinants of this complication diabetes have had limited success. In study, new international genomics consortium, JDRF funded Diabetic Nephropathy Collaborative Research Initiative, assembled nearly 20,000 samples from participants with type 1 diabetes, and without disease. The authors found 16 disease–associated loci at genome-wide significance. strongest signal...
Background: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality morbidity. We sought to identify genomic variants PAD overall in the contexts of diabetes smoking status. Methods: identified genetic then meta-analyzed published summary statistics from Million Veterans Program UK Biobank replicate their findings. Next, we ran stratified genome-wide association analysis ever smokers, never individuals diabetes, no history corresponding...
Abstract Recent familial segregation studies supported a multifactorial genetic model for the etiology of adolescent idiopathic scoliosis (AIS). However, extent quantitative effects, such as heritability, have not been fully evaluated. This epidemiology study examined sibling recurrent risk and heritability AIS in first‐degree relatives 415 Chinese female patients, which is up to now largest cohort. They were first diagnosed by community screening program compared 203 age‐matched normal...
Photocatalytic CO
Abstract Purpose: Targeting CD79B using antibody–drug conjugates (ADC) is an effective therapeutic strategy in B-cell non-Hodgkin lymphoma (B-NHL). We investigated DCDS0780A, anti-CD79B ADC with THIOMAB technology (TDC) that consistently two anti-neoplastic molecules per antibody, contrast ADCs heterogeneous loads. Patients and Methods: This phase 1 study enrolled 60 patients histologically confirmed B-NHL had relapsed/failed to respond following ≥1 prior treatment regimens; 41 (68%) diffuse...
// Li Bai 1,2,* , Zubin Yu 3,* Jiawei Zhang 4 Shuai Yuan 5 Chen Liao 1 Prince V.S. Jeyabal 2 Valentina Rubio Huarong 2,4 Yafei 5,** and Zheng-Zheng Shi 2,** Department of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, China Translational Imaging, Houston Methodist Research Institute, Houston, Texas, USA 3 Thoracic Surgery, Cancer The Second Affiliated School Medicine, Zhejiang Hangzhou, Epidemiology, College Preventive * These authors have contributed...
BACKGROUND CD4 + T helper 17 (Th17) cells play critical roles in inflammation and tumor development. The involvement of Th17 chronic obstructive pulmonary disease (COPD)‐type inflammation‐associated lung cancer has also been confirmed animal models. However, to the authors' knowledge, it is unknown whether role different patients with complicated COPD compared those without COPD. In current study, authors attempted determine association between circulating levels Th17‐related cytokines...
The aldose reductase inhibitor Fidarestat has been noted to have efficacy in treating a variety of tumors. To define its role hepatocellular carcinoma (HCC), we induced HCC xenograft model mice, which were treated with different doses Fidarestat. amounts natural killer (NK) cells and related inflammatory factors detected the serum mice. inhibited tumor growth lung metastasis vivo increased NK cell number as well levels cell-related mouse serum. then co-cultured line vitro detect effects on...
Although there have been reported benefits of health education interventions across various issues, the key to program effectiveness is participation and retention. Unfortunately, not everyone willing participate in upon invitation. In fact, are vulnerable low rates. The objective this study was identify design features that may increase evaluation surveys, maximize recruitment retention efforts a general ambulatory population.A cross-sectional questionnaire administered 175 individuals...
Analysis of gene expression in peripheral blood samples is increasingly being applied biomarker studies disease diagnosis and prognosis. Although knowledge interindividual interethnic variation required to set ethnicity-specific reference intervals select genes preferred markers from a list candidate genes, few have attempted characterize such biological on genomewide scale.The profiles 11 355 transcripts expressed among 210 multiethnic individuals the HapMap project were obtained analyzed;...
Diabetic kidney disease (DKD) is a heritable but poorly understood complication of diabetes. To identify genetic variants predisposing to DKD, we performed genome-wide association analyses in 19,406 individuals with type 1 diabetes (T1D) using spectrum DKD definitions basedon albuminuria and renal function. We identified 16 significant loci. The variant the strongest (rs55703767) common missense mutation collagen IV alpha 3 chain (COL4A3) gene, which encodes major structural component...
This study explores factors and attitudes that affect willingness to participate in health research an ambulatory population of 175 individuals. Respondents reported on their sociodemographic characteristics rated statements a questionnaire regarding likelihood toward research. Multivariate ordinal regression analysis revealed having more positive less negative research, access the Internet, previous participation experience, higher education, being Canadian-born contribute greater...
Supplementary Figure from Anti-CD79B Antibody–Drug Conjugate DCDS0780A in Patients with B-Cell Non-Hodgkin Lymphoma: Phase 1 Dose-Escalation Study
Abstract Background and aims Aspirin leads to substantial benefits for the secondary prevention of cardiovascular disease (CVD). We aimed cast more light on aspirin’s role primary CVD. Methods Databases were searched clinical trials comparing aspirin vs. no use in this meta-analysis. Efficacy safety profiles rigorously investigated. Trial sequential analysis (TSA) was used determine robustness results. Results Fourteen studies with 163 840 participants eligible (mean follow-up 6.2 y). intake...
Background: Although there have been reported benefits of health education interventions across various issues, the key to program effectiveness is participation and retention. Unfortunately, not everyone willing participate in upon invitation. In fact, are vulnerable low rates. The objective this study was identify design features that may increase evaluation surveys, maximize recruitment retention efforts a general ambulatory population.Methods: A cross-sectional questionnaire administered...