A5001789877- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Heavy Metal Exposure and Toxicity
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Noise Effects and Management
- Global Health Care Issues
- Trace Elements in Health
- Autophagy in Disease and Therapy
- Urban Transport and Accessibility
- Cancer-related gene regulation
- Neuroscience and Neuropharmacology Research
- NF-κB Signaling Pathways
- Allergic Rhinitis and Sensitization
- Energy and Environment Impacts
- Skin Protection and Aging
- Inflammatory mediators and NSAID effects
- RNA Research and Splicing
- Health, Environment, Cognitive Aging
- Inflammasome and immune disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Response and Inflammation
Army Medical University
2016-2025
Jiangxi Science and Technology Normal University
2024-2025
Guiyang Medical University
2022-2025
Daping Hospital
2025
First Affiliated Hospital of Jiangxi Medical College
2025
Nanchang University
2024-2025
Chongqing Medical and Pharmaceutical College
2021
Army Medical College
2020
Yunnan Center for Disease Control And Prevention
2017-2018
Air Force Medical University
2007-2017
Central nervous system (CNS) inflammation and autophagy dysfunction are known to be involved in the pathology of neurodegenerative diseases. Manganese (Mn), a neurotoxic metal, has potential induce microglia-mediated neuroinflammation as well dysfunction. NLRP3 (NLR family, pyrin domain containing 3)- CASP1 (caspase 1) inflammasome-mediated microglia specific relevance neurological However, mechanism driving these phenomena remains poorly understood. We demonstrate that Mn activates...
Manganese is an essential trace element required for normal development and bodily functions. However, exposure of the brain to excessive amounts manganese results in neurotoxicity. Although previous studies examining neurotoxicity have focused on neuronal injury, especially direct injury dopaminergic neurons, effects manganese-induced glial cells not been reported. The current study was designed examine effect microglial activation, underlying mechanism vivo. We established animal model...
Lead (Pb) is a well-known heavy metal in nature.Pb can cause pathophysiological changes several organ systems including central nervous system.Especially, Pb affect intelligence development and the ability of learning memory children.However, toxic effects mechanisms on are still unclear.To clarify Pb-induced neurotoxicity hippocampus, its effect memory, we chose Sprague-Dawley rats (SD-rats) as experimental subjects.We used Morris water maze to verify after treatment.We...
The etiological role of dysregulated autophagy in neurodegenerative diseases has been a subject intense investigation. While manganese (Mn) is known to cause dopaminergic (DAergic) neurodegeneration, it yet be determined whether the dysregulation plays Mn-induced neuronal injury. In this study, we investigated effect Mn on rat model manganism, disease associated with excessive exposure Mn. After single intrastriatal injection Mn, short- (4-12 h) and long-term (1-28 days) DAergic neurons were...
Dysregulation of long noncoding RNA (lncRNA) is known to be involved in numerous human diseases, including lung cancer. However, the precise biological functions most lncRNA remain elucidated. Here, we identified a novel up-regulated lncRNA, LINC01436 (RefSeq: NR_110419.1), non-small cell cancer (NSCLC). High expression was significantly associated with poor overall survival. Notably, transcriptionally repressed by E2F6 under normoxia, and inhibitory effect relieved hypoxic microenvironment....
Manganese has long been known to induce neurological degenerative disorders. Emerging evidence indicates that hyperphosphorylated tau is associated with neurodegenerative diseases, but whether such hyperphosphorylation plays a role in manganese-induced neurotoxicity remains unclear. To fill this gap, we investigated the effects of manganese on phosphorylation PC12 cells. In our present research, treatment cells increased at Ser199, Ser202, Ser396, and Ser404 as detected by Western blot....
The data concerning the association between environmental pollution and epilepsy attacks are limited. aim of this study was to explore acute air exposure attack.A hospital record-based carried out in Xi'an, a heavily-polluted metropolis China. Daily baseline were obtained. Time-series Poisson regression models applied analyze epilepsy.A 10 μg/m3 increase NO2, SO2, O3 concentrations corresponded 3.17% (95%Cl: 1.41%, 4.93%), 3.55% 1.93%, 5.18%), -0.84% -1.58%, 0.09%) outpatient-visits for on...
The correlation between enteritis, a common digestive disease, and exposure to ambient air pollutants has not been examined in comprehensive manner. aim of this study was determine whether an association short-term pollution outpatient visits for enteritis Xi'an, China, occurred using time-series investigation. Daily baseline data from January 1, 2013, December 31, 2015, were obtained. overdispersed Poisson generalized additive model used analyze the pollutant levels frequency enteritis. A...
Cyclooxygenase-2 (COX-2) is a critical enzyme implicated in chronic inflammation-associated cancer development. Our studies have shown that the exposure of Beas-2B cells, human bronchial epithelial cell line, to lung carcinogenic nickel compounds results increased COX-2 expression. However, signaling pathways leading nickel-induced expression are not well understood. In current study, we found cells resulted activation both nuclear factor activated T (NFAT) and factor- κB (NF-κB). The...
Hexavalent chromium [Cr(VI)] is recognized as a human carcinogen via inhalation. However, the molecular mechanisms by which Cr(VI) causes cancers are not well understood.We evaluated cyclooxygenase-2 (COX-2) expression and signaling pathway leading to this induction due exposure in cultured cells.We used luciferase reporter assay Western blotting determine COX-2 Cr(VI). We dominant negative mutant, genetic knockout, gene knockdown, chromatin immunoprecipitation approaches elucidate...