A5051208342- Gut microbiota and health
- Orthopedic Surgery and Rehabilitation
- Drug Transport and Resistance Mechanisms
- Bone fractures and treatments
- Ginseng Biological Effects and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Infections and Treatments
- Lipoproteins and Cardiovascular Health
- Diet and metabolism studies
- Total Knee Arthroplasty Outcomes
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Knee injuries and reconstruction techniques
- RNA modifications and cancer
- Advanced materials and composites
- Musculoskeletal pain and rehabilitation
- Cardiovascular Effects of Exercise
- Trauma Management and Diagnosis
- PARP inhibition in cancer therapy
- Physical Activity and Health
- Venous Thromboembolism Diagnosis and Management
- Metabolomics and Mass Spectrometry Studies
- Orthopaedic implants and arthroplasty
- Myofascial pain diagnosis and treatment
University of Rostock
2023
Charité - Universitätsmedizin Berlin
2018-2021
Abstract Aims Atherosclerotic cardiovascular disease (ACVD) is a major cause of mortality and morbidity worldwide, increased low-density lipoproteins (LDLs) play critical role in development progression atherosclerosis. Here, we examined for the first time gut immunomodulatory effects microbiota-derived metabolite propionic acid (PA) on intestinal cholesterol metabolism. Methods results Using both human animal model studies, demonstrate that treatment with PA reduces blood total LDL levels....
The immune system is considered a key driver of atherosclerosis, and beyond proteins microRNAs (miRs), long non-coding RNAs (lncRNAs) are implicated in control. We previously described that lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) involved cardiac innate immunity myocarditis model. Here, we investigated the impact MALAT1 deficiency upon atherosclerosis development. Heterozygous MALAT1-deficient ApoE−/− mice displayed massive dysregulation within 2 months even...
The mechanisms of interindividual variation lipid regulation by statins, such as the low-density lipoprotein cholesterol (LDL) lowering effects, are not fully understood yet. Here, we used a gut microbiota depleted mouse model to investigate relation between and regulatory property atorvastatin on blood lipids.Mice (C57BL/6) with intact or antibiotic induced abiotic mice (ABS) were put standard chow diet (SCD) high fat (HFD) for six weeks. Atorvastatin (10 mg/kg body weight/day) control...
This study aimed to evaluate both publication and authorship characteristics in Knee Surgery, Sports Traumatology, Arthroscopy journal (KSSTA) regarding knee arthroplasty over the past 15 years.PubMed was searched for articles published KSSTA between January 1, 2006, December 31st, 2020, utilising search term 'knee arthroplasty'. 1288 met inclusion criteria. The were evaluated using following criteria: type of article, study, main topic special topic, use patient-reported outcome scores,...
Abstract Background and aims The modulation of serum lipids, in particular the low-density lipoprotein cholesterol (LDL-C), by statins varies between individuals. mechanisms regulating this interindividual variation are only poorly understood. Here, we investigated relation gut microbiome regulatory properties atorvastatin on lipidome using mice with depleted microbiome. Methods Over a period 6 weeks, (C57BL/6) either an intact (conventional mice, CONV, n=24) or antibiotic-based (antibiotic...
The history of total hip arthroplasty dates back to the first half twentieth century. Data on endoprostheses implanted during 1960s and 1970s suggest widely varying survival rates prosthesis.A case a patient who underwent in 1972 using Sivash prosthesis, developed 1956 former Soviet Union, is presented this article. prosthesis has remained unrevised patient's body for 50 years he continues be free implant-related symptoms. Despite constrained metal-on-metal design implant, which can lead...
Abstract Background and aims Statins show interindividual differences in the extent of low-density lipoprotein cholesterol (LDL-C) reduction. The mechanisms this variation are not fully understood. Here, we examined potential role gut microbiome for LDL-C lowering property atorvastatin. Methods Mice (C57BL/6) with either intact (conventional mice, CONV, n=24) or antiobiotic depleted (gnotobiotic, n=16), were put on standard chow diet (SCD) (n=11) high fat (HFD) (n=29) 6 weeks. During last 4...