A5075901202- Lipoproteins and Cardiovascular Health
- Cardiac Health and Mental Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Acute Myocardial Infarction Research
- Angiogenesis and VEGF in Cancer
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Risk Factors
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Dietary Effects on Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Congenital heart defects research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Disease Prevention
- Pharmacology and Obesity Treatment
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Cardiac pacing and defibrillation studies
- Health and Medical Research Impacts
- Protease and Inhibitor Mechanisms
- Restless Legs Syndrome Research
- Health Systems, Economic Evaluations, Quality of Life
- Lymphatic System and Diseases
Emory University
2016-2025
Emory Clinic
2017-2023
Cardiovascular Institute Hospital
2020-2021
Emory Healthcare
2020-2021
Clinical Research Institute
2019
Emory and Henry College
2019
George Washington University
2017
Previous studies have shown lower cardiovascular risk with higher high-density lipoprotein cholesterol (HDL-C) levels. However, recent data in the general population increased of adverse outcomes at very high HDL-C concentrations.To study association between levels (>80 mg/dL) and mortality patients coronary artery disease (CAD) to investigate known genotypes level outcomes.This prospective, multicenter, cohort study, conducted from 2006 present UK 2003 Atlanta, Georgia, recruited CAD...
Abstract High-density lipoprotein (HDL) contributes to reverse cholesterol transport, which is 1 of the main explanations for described inverse association between HDL-cholesterol (HDL-C) and atherosclerotic cardiovascular disease (ASCVD) risk. However, efforts therapeutically raise HDL-C levels with niacin, fibrates, or cholesteryl ester transfer protein inhibitors have not demonstrated a reduction in ASCVD events when compared placebo among individuals treated statins. Furthermore,...
Background Educational attainment is an indicator of socioeconomic status and inversely associated with coronary artery disease risk. Whether educational level ( EAL ) among patients influences outcomes remains understudied. Methods Results Patients undergoing cardiac catheterization had their highest assessed using options elementary/middle school, high college, or graduate education. Primary outcome was all‐cause mortality secondary were a composite cardiovascular death/non‐fatal...
Vitamin D deficiency (VDD) is associated with coronary heart disease (CHD) and poor outcomes, but supplementation does not improve prognosis. VDD has been implicated in may promote greater risk through inflammation impaired progenitor cell function.
Background Patients with ischemic cardiomyopathy (ICM) have worse outcomes than those coronary artery disease alone and non-ICM. N8-acetylspermidine (N8AS) is a polyamine that regulates cardiac apoptosis resultant dysfunction. We hypothesized N8AS mechanistic biomarker of adverse in patients ICM. Methods Results High-resolution plasma metabolomics profiling mass spectrometry were used to quantitate levels discovery cohort 474 (age: 68±11 years, 12% black, 26% women): 154 ICM, 320 without...
Patients with CAD have substantial residual risk of mortality, and whether hitherto unknown small-molecule metabolites metabolic pathways contribute to this is unclear. We sought determine the predictive value plasma metabolomic profiling in patients CAD.Untargeted high-resolution subjects undergoing coronary angiography was performed using liquid chromatography/mass spectrometry. Metabolic features associated mortality were identified 454 metabolome-wide association studies Mummichog,...
Many molecular factors required for later stages of neuronal differentiation have been identified; however, much less is known about the early events that regulate initial establishment neuroectoderm. We used an in vitro embryonic stem cell (ESC) model to investigate and define role mouse Foxd4, ortholog a forkhead-family transcription factor central Xenopus neural plate/neuroectodermal precursor development. found Foxd4 necessary regulator transition from pluripotent ESC neuroectodermal...
Background Women have higher circulating levels of soluble urokinase‐type plasminogen activator receptor (suPAR), and elevated suPAR is associated with cardiovascular risk. The independent association sex the impact on its risk are unknown. Methods Results Plasma was measured using ELISA in 2 cohorts 666 asymptomatic individuals (49 years, 65% women) 4184 patients coronary artery disease (63 37% women). Independent studied linear regression models adjusted for demographics, factors, visceral...
Despite guideline-based therapy, patients with coronary artery disease (CAD) are at widely variable risk for cardiovascular events. This variability demands a more individualized assessment. Herein, we evaluate the prognostic value of 6 biomarkers: high-sensitivity C-reactive protein, heat shock protein-70, fibrin degradation products, soluble urokinase plasminogen activator receptor, troponin I, and B-type natriuretic peptide. We then develop multi-biomarker-based event prediction model...