A5006770720- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Renal cell carcinoma treatment
- Advances in Oncology and Radiotherapy
- Health Systems, Economic Evaluations, Quality of Life
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Analysis
- Advanced MRI Techniques and Applications
- Management of metastatic bone disease
- Patient-Provider Communication in Healthcare
- Intraperitoneal and Appendiceal Malignancies
- Advanced X-ray and CT Imaging
- Patient Satisfaction in Healthcare
- Medical Malpractice and Liability Issues
- Colorectal Cancer Surgical Treatments
- Urological Disorders and Treatments
- Ethics in Clinical Research
- Statistical Methods in Clinical Trials
Liverpool Hospital
2015-2024
UNSW Sydney
2012-2024
Cancer Australia
2012-2024
South Western Sydney Local Health District
2017-2024
Basingstoke and North Hampshire Hospital
2023-2024
Northampton General Hospital
2023
Hampshire Hospitals NHS Foundation Trust
2023
National Health Service
2023
Kingston Hospital
2023
Ingham Institute
2015-2022
Objectives To test the hypothesis that observation with early salvage radiotherapy ( SRT ) is not inferior to ‘standard’ treatment adjuvant RT ART respect biochemical failure in patients pT3 disease and/or positive surgical margins SMs after radical prostatectomy RP ). compare following secondary endpoints between two arms: patient‐reported outcomes, adverse events, failure‐free survival, overall disease‐specific time distant failure, local cost utility analysis, quality adjusted life years...
Multidisciplinary meetings (MDMs) are increasingly being mandated as essential to oncology practice. However, there is a paucity of data on their effectiveness. The aim this study was assess whether MDM recommendations were concordant with guidelines in the treatment lung cancer.The Lung Cancer Meeting South West Sydney, Australia, prospectively collects all patients whose cases have been presented. New cancer who presented between December 1, 2005, and 31, 2007, reviewed. Patients assigned...
Bio-medical image segmentation models typically attempt to predict one that resembles a ground-truth structure as closely possible. However, medical images are not perfect representations of anatomy, obtaining this ground truth is A surrogate commonly used have multiple expert observers define the same for dataset. When on there can be significant differences depending structure, quality/modality and region being defined. It often desirable estimate type aleatoric uncertainty in model help...
Objective: Diffusion-weighted imaging (DWI) is an important technique for the localization of prostate cancer, and its response assessment during treatment with radiotherapy (RT). However, it has known limitations in terms distortions artefacts using standard acquisition techniques. This study evaluates two alternative methods that offer promise improved image quality potential more reliable consistent diffusion data. Methods: Three DWI techniques were investigated; single-shot echoplanar...
Objectives To report feasibility, early toxicity and PSA kinetics following gantry-based, stereotactic radiotherapy (SBRT) boost within a prospective, phase 2, multicentre study (PROMETHEUS: ACTRN12615000223538) Methods Patients were treated with gantry-based SBRT, 19-20 Gy in 2 fractions delivered one week apart, followed by conventionally fractionated IMRT (46 23 fractions). The mandated MRI fusion for RT planning, rectal displacement intrafraction image guidance. Toxicity was...
Purpose: This project investigates the feasibility of implementation MRI-only prostate planning in a prospective multi-center study. Method and /Materials: A two-phase model was utilized where centers performed retrospective analysis plans for 5 patients followed by subsequent patients. Feasibility assessed if at least 23/25 recruited to phase 2 received treatment workflow. Whole-pelvic MRI scans (T2 weighted, isotropic 1.6 mm voxel 3D sequence) were converted pseudo-CT using an established...
Background and objectiveDespite the high efficacy of high-dose-rate brachytherapy boost (HDRB) in management prostate cancer (PC), use this approach is declining. Similar dosimetry can be achieved using stereotactic body radiotherapy or "virtual HDRB" (vHDRB). The aim multicentre, single-arm, phase 2 PROMETHEUS trial (ACTRN12615000223538) was to evaluate safety vHDRB patients with PC.MethodsPatients intermediate-risk PC selected high-risk were eligible for inclusion. given as 19–20 Gy two...