A5018910891- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Ophthalmology and Visual Impairment Studies
- Photoacoustic and Ultrasonic Imaging
- Coronary Interventions and Diagnostics
- Urological Disorders and Treatments
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Pelvic floor disorders treatments
Calvary Mater Newcastle Hospital
2016-2024
Objectives To report feasibility, early toxicity and PSA kinetics following gantry-based, stereotactic radiotherapy (SBRT) boost within a prospective, phase 2, multicentre study (PROMETHEUS: ACTRN12615000223538) Methods Patients were treated with gantry-based SBRT, 19-20 Gy in 2 fractions delivered one week apart, followed by conventionally fractionated IMRT (46 23 fractions). The mandated MRI fusion for RT planning, rectal displacement intrafraction image guidance. Toxicity was...
Background and objectiveDespite the high efficacy of high-dose-rate brachytherapy boost (HDRB) in management prostate cancer (PC), use this approach is declining. Similar dosimetry can be achieved using stereotactic body radiotherapy or "virtual HDRB" (vHDRB). The aim multicentre, single-arm, phase 2 PROMETHEUS trial (ACTRN12615000223538) was to evaluate safety vHDRB patients with PC.MethodsPatients intermediate-risk PC selected high-risk were eligible for inclusion. given as 19–20 Gy two...
Kilovoltage Intrafraction Monitoring (KIM) is a method which determines the three-dimensional position of prostate from two-dimensional kilovoltage (kV) projections taken during linac based radiotherapy treatment with real-time feedback. Rectal displacement devices (RDDs) allow for improved rectal dosimetry cancer treatment. This study used KIM to perform preliminary investigation intrafraction motion observed in patients an RDD place.Ten intermediate high-risk were treated Rectafix place...
MOSFET dosimetry is a method that has been used to measure in-vivo doses during brachytherapy treatments and linac based radiotherapy treatment. Rectal displacement devices (RDDs) allow for safe dose escalation prostate cancer This study dual MOSkin detectors assess real-time in vivo rectal wall patients with an RDD place high stereotactic body radiation therapy (SBRT) boost trial.The PROMETHEUS commenced 2014 provides SBRT place. Twelve received two fractions of 9.5-10 Gy each delivered the...
PROMETHEUS (ACTRN12615000223538) is a multicentre clinical trial investigating the feasibility of 19 Gy in 2 fractions stereotactic body radiotherapy (SBRT) as boost technique for prostate cancer. The objective this substudy was to evaluate intrafraction motion using cine MRI and assess dosimetric impact rectal displacement device (RDD).
Abstract Introduction High rectal doses are associated with increased toxicity. A displacement device ( RDD ) reduces dose in prostate stereotactic body radiation therapy SBRT ). This study investigates any dosimetric difference between two methods of (Rectafix and Space OAR for . Methods Rectal dosimetry 45 men who received within the PROMETHEUS trial was retrospectively examined, across centres using 's. Men a total TD 19 or 20 Gy fractions followed by 46 23 fractions. Centre 1 contributed...
High Dose Rate Brachytherapy (HDRB) boost is a well-established treatment for prostate cancer (PC). We describe the PROstate Multicentre External beam radioTHErapy Using Stereotactic (PROMETHEUS) study. Non-surgical stereotactic techniques are used to deliver similar doses HDRB regimens with dose escalation sub-study. Eligible patients have intermediate or high risk PC. PROMETHEUS explores safety, efficacy and feasibility of multiple Australian centres cooperating in delivery Prostate Body...
Abstract Introduction The prostatic urethra is an organ at risk for prostate radiotherapy with genitourinary toxicities a common side effect. Many external beam radiation therapy protocols call urethral sparing, and modulated techniques, the dose distribution can be controlled so that maximum doses do not fall within volume. Whilst traditional diagnostic MRI sequences provide excellent delineation of prostate, uncertainty often remains as to true path gland. This study aims assess if...
Abstract Purpose The US National Institutes of Health state that Sharing clinical trial data has great potential to accelerate scientific progress and ultimately improve public health by generating better evidence on the safety effectiveness therapies for patients ( https://www.ncbi.nlm.nih.gov/books/NBK285999/ accessed 2024‐01‐24.). Aligned with this initiative, Trial Management Committee Trans‐Tasman Radiation Oncology Group (TROG) 15.01 Stereotactic Prostate Adaptive Radiotherapy...
Purpose or ObjectiveAfter external beam radiotherapy (EBRT) for prostate cancer, the most common site of recurrence is prostate.The aim was to assess efficacy and safety salvage stereotactic body (SBRT) local cancer after radiotherapy. Material MethodsWe retrospectively reviewed patients with biopsy proven EBRT brachytherapy in centers from French Genito-Urinary Group (GETUG) European Institute Oncology Milan.Disease extension assessed by pelvic multiparametric MRI choline PET 87% 94%...
Purpose: To determine prostate motion during SBRT boost treatments with a Rectafix rectal sparing device in place using kV imaging treatment. Methods: Patients each had three gold fiducial markers inserted into the and received two VMAT fractions of 9.5–10 Gy under PROMETHEUS clinical trial protocol retractor place. Two‐dimensional kilovoltage images were acquired continuously delivery. Three patients treated on Varian Clinac iX linear accelerator (6X, 600 MU/min), where at 5 Hz Seven...