A5086630025- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Medical Imaging and Analysis
- Nutrition and Health in Aging
- Cardiovascular Function and Risk Factors
- Head and Neck Cancer Studies
- Medical Image Segmentation Techniques
- Advanced X-ray and CT Imaging
- Urologic and reproductive health conditions
- Acute Myocardial Infarction Research
- Dental Radiography and Imaging
- Hip and Femur Fractures
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Hip disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Radiology practices and education
- Urological Disorders and Treatments
UNSW Sydney
2016-2025
Prince of Wales Hospital
2016-2025
The University of Sydney
2008-2023
McGill University
2016-2022
Royal Hospital for Women
2022
Liverpool Hospital
2008-2019
South Western Sydney Local Health District
2015-2019
Garvan Institute of Medical Research
2018
Campbell University
2016
Western Sydney University
2016
Multiparametric magnetic resonance imaging appears to improve prostate cancer detection but prospective studies are lacking. We determined the accuracy of multiparametric for detecting significant before diagnostic biopsy in men with abnormal specific antigen/digital rectal examination.In this single center, study older than 40 years examination and no previous underwent T2-weighted, diffusion-weighted dynamic contrast enhanced without an endorectal coil. Imaging was allocated alternately...
No AccessJournal of UrologyAdult Urology1 May 2016The Diagnostic Performance Multiparametric Magnetic Resonance Imaging to Detect Significant Prostate Cancer J.E. Thompson, P.J. van Leeuwen, D. Moses, R. Shnier, P. Brenner, W. Delprado, M. Pulbrook, Böhm, A.M. Haynes, A. Hayen, and P.D. Stricker ThompsonJ.E. Thompson St. Vincent’s Centre, Darlinghurst, New South Wales, Australia Garvan Institute Medical Research, Kinghorn School Medicine, University Kensington, More articles by this author ,...
Objective To develop and externally validate a predictive model for detection of significant prostate cancer. Patients Methods Development the was based on prospective cohort including 393 men who underwent multiparametric magnetic resonance imaging (mp MRI ) before biopsy. External validity then examined retrospectively in 198 from separate institution whom mp followed by biopsy abnormal prostate‐specific antigen ( PSA level or digital rectal examination DRE ). A developed with age, level,...
Background Radiomic analysis is defined as computationally extracting features from radiographic images for quantitatively characterizing disease patterns. There has been recent interest in examining the use of MRI identifying prostate cancer (PCa) aggressiveness patients on active surveillance (AS). Purpose To evaluate performance MRI‐based radiomic presence or absence clinically significant PCa AS patients. Study Type Retrospective. Subjects Model MRI/TRUS (transperineal grid ultrasound)...
Background: Prostate cancer (PCa) influences its surrounding habitat, which tends to manifest as different phenotypic appearances on magnetic resonance imaging (MRI). This region the PCa lesion, or peri-tumoral region, may encode useful information that can complement intra-tumoral enable better risk stratification. Purpose: To evaluate role of radiomic features bi-parametric MRI (T2-weighted and Diffusion-weighted) distinguish categories defined by D’Amico Risk Classification System....
Prospective studies are lacking in assessing the diagnostic utility of serial multiparametric magnetic resonance imaging to predict biopsy proven progression clinically significant prostate cancer men on active surveillance, as well oncologic safety baseline and saturation replacing early confirmatory during surveillance.A total 172 were enrolled this single arm prospective trial. Men with cT2 or lower histologically (Gleason 3+3=6 Gleason 3+4=7 10% less pattern 4 overall than 2 cores 4)...
By the time a patient first presents with symptoms of Parkinsons disease at clinic, significant proportion (50-70%) cells in substantia nigra (SN) has already been destroyed. This degeneration progresses until, within few years, most have died. Except for rare cases familial PD, initial trigger cell loss is unknown. However, we do some clues as to why damage, once initiated, unabated. It would represent major advance therapy arrest stage when clinic. Current therapies focus on relieving...
The aim is to report the results of Australia's first uterus transplantation (UTx).Following long-standing collaboration between Swedish and Australian teams, Human Research Ethics approval was obtained perform six UTx procedures in a collaborative multi-site research study (Western Sydney Local District Health 2019/ETH13038), including Royal Hospital for Women, Prince Wales Hospital, Westmead New Souh Wales. Surgeries were approved both live donor (LD) deceased models with inaugural...
Abstract Purpose To investigate whether the loss of corticomedullary differentiation (CMD) on T1‐weighted MR images due to renal insufficiency can be attributed changes in T1 values cortex, medulla, or both. Materials and Methods Study subjects included 10 patients (serum creatinine range 0.6–3.0 mg/dL) referred for suspected renovascular disease who underwent 99m Tc‐diethylene triamine pentaacetic acid (DTPA) renography determine single kidney glomerular filtration rate (SKGFR) same‐day...
Objective: Diffusion-weighted imaging (DWI) is an important technique for the localization of prostate cancer, and its response assessment during treatment with radiotherapy (RT). However, it has known limitations in terms distortions artefacts using standard acquisition techniques. This study evaluates two alternative methods that offer promise improved image quality potential more reliable consistent diffusion data. Methods: Three DWI techniques were investigated; single-shot echoplanar...
To test a free-breathing MRI protocol for anatomical and functional assessment during lung cancer radiotherapy by assessing two non-Cartesian acquisition schemes based on T1 weighted 3D gradient recall echo sequence: (i) stack-of stars (StarVIBE) (ii) spiral (SpiralVIBE) trajectories.MR images five healthy volunteers were acquired wide bore 3T scanner (MAGNETOM Skyra, Siemens Healthcare, Erlangen, Germany). Anatomical image quality was assessed on: (1) free breathing (StarVIBE), (2) the...
The bone age of a child indicates the skeletal and biological maturity an individual. most commonly applied clinical methods for Bone Age Assessment (BAA) are based on visual examination ossification individual bones in radiographs left hand wrist by comparing with standard atlas. This kind method is highly subjective performance extremely depends practitioners' experiences. paper investigates use Deep Convolutional Neural Networks (DCNNs) automatic assessment. As there exists no large-scale...
Left ventricular (LV) thrombus is a complication of acute ST-segment elevation myocardial infarction (STEMI). We determined the incidence and predictors LV formation using serial cardiac magnetic resonance (CMR) two-dimensional echocardiography studies. Two hundred ten patients underwent CMR (median 4 days [IQR 3-7]) transthoracic early after STEMI presentation with follow-up 55 46-64]) studies 54 45-64]) performed subsequently. The was 12.3% (26/210) by 6.2% (13/210) echocardiography....
Abstract Background Computed tomography (CT)‐defined sarcopenia is a prognostic indicator in head and neck cancer (HNC), with the gold standard for muscle evaluation using cross‐sectional area (CSA) at third lumbar vertebra (L3). We compared methods CSA cervical (C3). Methods Muscle was measured L3, C3 used to estimate L3 prediction model. Agreement diagnosis were evaluated. Results Good correlation found between estimated (101 scans; r = 0.86, p < 0.001). mean difference (bias) 9.99 cm 2...
Objective To evaluate the accuracy of combined multiparametric magnetic resonance imaging (mp MRI ) and transperineal template‐guided mapping biopsy ( TTMB for identifying lobes with significant prostate cancer PC a) application hemi‐ablative focal therapy FT ). Patients Methods From January 2012 to 2014, 89 consecutive patients, aged ≥40 years, a PSA level ≤15 ng/mL, underwent in sequential order: mpMRI, radical prostatectomy (RP) at single centre. Analysis was performed on 50 patients who...
Response to neoadjuvant chemoradiotherapy (CRT) of rectal cancer is variable. Accurate imaging for prediction and early assessment response would enable appropriate stratification management reduce treatment morbidity improve therapeutic outcomes. Use either diffusion weighted (DWI) or dynamic contrast enhanced (DCE) alone currently lacks sufficient sensitivity specificity clinical use guide individualized in cancer. Multi-parametric MRI analysis combining DWI DCE may have potential the...
Vertebral compression fractures often go clinically undetected and consequently untreated, resulting in severe secondary due to osteoporosis, potentially leading permanent disability or even death. Automated detection of vertebral (VCF) could assist routine screening followup incidentally scanned patients, thereby mitigating later. A novel fully automated method for the VCF 3D computed tomography (CT) chest abdomen is presented this work. It starts with localisation thoracic lumbar spine...
Abstract Objectives To test if tumour changes measured using combination of diffusion-weighted imaging (DWI) MRI and FDG-PET/CT performed serially during radiotherapy (RT) in mucosal head neck carcinoma can predict treatment response. Methods Fifty-five patients from two prospective biomarker studies were analysed. was at baseline, RT (week 3), post (3 months). DWI (weeks 2, 3, 5, 6), (1 3 The ADC mean FDG-PET parameters SUV max , metabolic volume (MTV), total lesion glycolysis (TLG)...
Abstract Background Microvascular scarring compromises the functionality of endometrium, and vascular flow at junctional zone (JZ) may be key to understanding poor reproductive outcomes in women with Asherman syndrome (AS). Aims To investigate whether perfusion uterus, measured by dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) is impaired intrauterine adhesions (IUA) AS. Materials Methods A prospective observational cohort pilot study 23 IUA treated hysteroscopic synecholysis...
Background: In Nigeria, it is estimated that about 1.9 million people were living with HIV in 2019, a national prevalence of 1.4% among adults aged 15-49 years. status disclosure and adherence to Highly Active Antiretroviral Therapy (HAART) medication important for the prevention control HIV/AIDS. Several factors have been identified as being associated increased HAART including disclosure. Disclosure pose great challenge our society due stigma other negative consequences. The aim this study...
Objective Giant cell arteritis (GCA) is characterized by cranial ischemia at diagnosis and late aortic structural disease. Repeated combined large‐vessel fluoro‐2‐deoxyglucose (FDG) positron emission tomography (PET)/computed (CT) scans were performed to assess the distribution of vasculitis activity over time relationship with clinical outcomes. Methods Patients eligible if they enrolled in a 64‐patient inception suspected GCA cohort 2016 2017 had positive temporal artery biopsy and/or...