A5076470455- Dental materials and restorations
- Dental Erosion and Treatment
- Endodontics and Root Canal Treatments
- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Bone and Dental Protein Studies
- Protease and Inhibitor Mechanisms
- Dental Radiography and Imaging
- Orthodontics and Dentofacial Orthopedics
- Dental Anxiety and Anesthesia Techniques
- Dental Trauma and Treatments
- Dental Research and COVID-19
- dental development and anomalies
- Salivary Gland Disorders and Functions
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Oral and gingival health research
- Oral Health Pathology and Treatment
- Laser Applications in Dentistry and Medicine
- Smoking Behavior and Cessation
- Temporomandibular Joint Disorders
- Nutritional Studies and Diet
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Oral and Maxillofacial Pathology
University of Helsinki
2015-2025
Oulu University Hospital
2014-2023
University of Oulu
2014-2023
Helsinki University Hospital
2009-2023
University of Gothenburg
2023
Norwegian University of Science and Technology
2023
University of Oslo
2023
Malmö University
2023
University of Bergen
2023
Karolinska Institutet
2020
Matrix metalloproteinases (MMPs) are a family of enzymes which, in concert, capable degrading collagen. We investigated whether human MMPs could participate the degradation dentin organic matrix after demineralization. performed Western blot analyses using MMP-specific antibodies to identify dental caries lesions. Enzymography and functional activity assays, with 125 I-labeled gelatin as substrate or quantitating type I collagen, were used determine purified salivary gelatinolytic (MMP-2...
The recent paradigm that endogenous collagenolytic and gelatinolytic activities derived from acid-etched dentin result in degradation of hybrid layers requires vivo validation. This study tested the null hypothesis there is no difference between bonded with an etch-and-rinse adhesive conjunction chlorhexidine, MMP inhibitor, applied after phosphoric-acid-etching. Contralateral pairs Class I restorations primary molars clinical subjects were retrieved a six-month period intra-oral functioning...
Host-derived proteases have been reported to degrade the collagen matrix of incompletely-resin-infiltrated dentin. This study tested hypothesis that interfacial degradation resin-dentin bonds may be prevented or delayed by application chlorhexidine (CHX), a metalloproteinase inhibitor, dentin after phosphoric acid-etching. Contralateral pairs resin-bonded Class I restorations in non-carious third molars were kept under intra-oral function for 14 months. Preservation was assessed microtensile...
Loss of hybrid layer integrity compromises resin-dentin bond stability. Matrix metalloproteinases (MMPs) may be partially responsible for degradation. Since chlorhexidine inhibits MMPs, we hypothesized that would decelerate the loss bonds. Class I preparations in extracted third molars were sectioned into two halves. One half was customarily restored (etch-and-rinse adhesive/resin composite), and other treated with 2% after being acid-etched before restoration. Specimens stored artificial...
Mild acids are known to activate dentin matrix metalloproteinase (MMPs). All self‐etching dental adhesives acidic (pH 1.5–2.7) and may MMPs. The purpose of this study was compare the ability several all‐in‐one gelatinolytic collagenolytic activities in powdered mineralized dentin. Powdered made from human teeth mixed with (Clearfil Tri‐S Bond, G‐Bond, Adper Prompt L‐Pop) or a primer SE Bond primer) for varying times then reaction stopped by extracting using acetone. Fresh untreated powder...
The co-expression of MMPs and cysteine cathepsins in the human dentin-pulp complex indicates that both classes enzymes can contribute to endogenous proteolytic activity dentin. Chlorhexidine (CHX) is an efficient inhibitor MMP activity. This study investigated whether CHX could also inhibit present inhibitory profile on dentin-extracted recombinant (B, K, L) was monitored fluorogenic substrates. rate substrate hydrolysis spectrofluorimetrically measured, constants were calculated. Molecular...