A5103067018- Gut microbiota and health
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Apelin-related biomedical research
- Paraoxonase enzyme and polymorphisms
- Machine Learning and Data Classification
- Statistical Methods and Inference
- Heart Failure Treatment and Management
- Cynara cardunculus studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Health and Mental Health
- Cardiovascular Function and Risk Factors
- Gene expression and cancer classification
- Nutritional Studies and Diet
- Nitric Oxide and Endothelin Effects
- Dialysis and Renal Disease Management
- Cardiac Fibrosis and Remodeling
- Trace Elements in Health
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Blood properties and coagulation
- Data Analysis with R
- Pharmaceutical Economics and Policy
- Molecular Biology Techniques and Applications
- Acute Myocardial Infarction Research
Cleveland State University
2011-2025
Cleveland Clinic
2011-2013
Cleveland Clinic Lerner College of Medicine
2012
University of Southern California
2011-2012
University of Ottawa
2011-2012
Center for Human Genetics
2012
Massachusetts General Hospital
2012
Recent metabolomics and animal model studies show trimethylamine-N-oxide (TMAO), an intestinal microbiota-dependent metabolite formed from dietary trimethylamine-containing nutrients such as phosphatidylcholine (PC), choline, carnitine, is linked to coronary artery disease pathogenesis. Our aim was examine the prognostic value of systemic choline betaine levels in stable cardiac patients.We examined relationship between fasting plasma risk major adverse events (MACE = death, myocardial...
Background Trimethylamine‐ N ‐oxide ( TMAO ), a metabolite derived from gut microbes and dietary phosphatidylcholine, is linked to both coronary artery disease pathogenesis increased cardiovascular risks. The ability of plasma predict 5‐year mortality risk in patients with stable has not been reported. This study examined the clinical prognostic value who met eligibility criteria for patient cohort similar that Clinical Outcomes Utilizing Revascularization Aggressive Drug Evaluation...
Recent studies show a mechanistic link between intestinal microbial metabolism of dietary phosphatidylcholine and coronary artery disease pathogenesis. Concentrations proatherogenic gut microbe-generated metabolite, trimethylamine N-oxide (TMAO), predict increased incident cardiovascular risks in multiple cohorts. TMAO concentrations are patients with type 2 diabetes mellitus (T2DM), but their prognostic value relation to glycemic control unclear.We examined the relationship fasting its...
Objective— Diminished serum paraoxonase and arylesterase activities (measures of paraoxonase-1 [PON-1] function) in humans have been linked to heightened systemic oxidative stress atherosclerosis risk. The clinical prognostic use measuring distinct PON-1 has not established, the genetic determinants are known. Methods Results— We established analytically robust high-throughput assays for measured these 3668 stable subjects undergoing elective coronary angiography without acute syndrome were...
Production of the proatherogenic metabolite, trimethylamine N-oxide (TMAO), from dietary nutrients by intestinal microbiota enhances atherosclerosis development in animal models and is associated with atherosclerotic coronary artery disease humans. The utility studying plasma levels TMAO to risk stratify patients peripheral (PAD) has not been reported.We examined relationship between fasting all-cause mortality (5-year), stratified subtypes PAD presence 935 who underwent elective angiography...
Background--Decreased serum arylesterase activity, catalyzed by the high-density lipoprotein-associated paraoxonase (PON)-1, is associated with increased oxidant stress and atherosclerosis risk.We sought to determine prognostic value of PON-1 as monitored PON or activities, in subjects chronic kidney disease (CKD), particularly relation established cardiac biomarkers.Methods Results--Serum activities were measured sequential CKD (n=630; estimated glomerular filtration rate [eGFR] <60 mL/min...
Ceruloplasmin (Cp) is an acute-phase reactant that increased in inflammatory diseases and acute coronary syndromes. Cp has recently been shown to possess nitric oxide (NO) oxidase catalytic activity, but its impact on long-term cardiovascular outcomes stable cardiac patients not explored.We examined serum levels their relationship with incident major adverse events (MACE; death, myocardial infarction [MI], stroke) over 3-year follow-up 4177 undergoing elective angiography. We also carried...
Background Decreased serum arylesterase activity, catalyzed by the high‐density lipoprotein–associated paraoxonase ( PON )‐1, is associated with increased oxidant stress and atherosclerosis risk. We sought to determine prognostic value of ‐1 as monitored or activities, in subjects chronic kidney disease CKD ), particularly relation established cardiac biomarkers. Methods Results Serum activities were measured sequential (n=630; estimated glomerular filtration rate [ eGFR ] <60 mL/min per...
Background Few studies have investigated functional capacity self‐assessment tools in either prediction of future major adverse cardiac outcomes beyond all‐cause mortality or direct comparisons with clinically available biomarkers. Methods and Results We estimated using the Duke Activity Status Index ( DASI ) questionnaire 8987 sequential stable patients without acute coronary syndrome who were undergoing elective diagnostic angiography 3‐year follow‐up events (death, nonfatal myocardial...
Increased serum levels of the acute-phase reactant ceruloplasmin predict adverse clinical outcomes in setting acute coronary syndromes and heart failure, but their role patients with CKD is unclear. This study investigated relationship CKD, especially regard to traditional cardiac biomarkers.Serum consecutive participants (n=654; estimated GFR<60 ml/min per 1.73 m(2)) as well a control group non-CKD matched for age sex (n=250) were measured. Study enrolled during 2001-2006 from population...