A5060479677- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Astrophysical Phenomena and Observations
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Vascular Procedures and Complications
- Gastroesophageal reflux and treatments
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- Urticaria and Related Conditions
- Bone and Dental Protein Studies
- ECG Monitoring and Analysis
- Vasculitis and related conditions
- Eosinophilic Disorders and Syndromes
- Coronary Artery Anomalies
- Cardiovascular Effects of Exercise
- Aortic Disease and Treatment Approaches
Istituto Nazionale di Fisica Nucleare, Sezione di Milano Bicocca
2023
Brera Astronomical Observatory
2023
University of Insubria
2023
University Hospital of Geneva
2009-2020
University of Genoa
2016-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2016
Ospedale Policlinico San Martino
2016
Geneva College
2013-2015
Hôpital de la Tour
2012-2014
Ospedale Regionale di Locarno
2011
Recurrences of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) are usually caused by pulmonary vein (PV) re-conduction, foci outside the PV or previous electrical remodelling. Substrate alterations with conduction delays may be detected signal-averaged P-wave analysis (SAPW). This study was conducted to assess value SAPW predict recurrences RFCA in patients paroxysmal persistent AF.One hundred and two (59 ± 10 years, 83 males) underwent a first procedure for (n = 61)...
Several chemotherapy molecules, monoclonal antibodies and tyrosine kinase inhibitors, have been linked to Takotsubo cardiomyopathy (TC). In this article, we describe the case of a 45-year-old woman who developed TC after receiving an intra-arterial intra-venous polychemotherapy for locally advanced epidermoid carcinoma anal canal. This is first described associated with chemotherapy. A review literature points 5-fluorouracil as most common molecule highlights potential risk rechallenging...
Objectives: Few reports address the relationship between hemodynamic variables and cardiogenic shock outcome in critically ill patients. The present study aimed to investigate association early mortality Design: Retrospective, single-center cohort study. Setting: Tertiary academic hospital's 36-bed multidisciplinary intensive care. Patients: Initial presentation with shock. Measurements Main Results: authors retrospectively analyzed medical information (recorded during first 24 hr following...
Aims: Our aim was to compare the safety and efficacy of a novel, ultrathin strut, biodegradable polymer sirolimus-eluting stent (BP-SES) with thin durable everolimus-eluting (DP-EES) in pre-specified subgroup patients acute ST-segment elevation myocardial infarction (STEMI) enrolled BIOSCIENCE trial. Methods results:The trial is an investigator-initiated, single-blind, multicentre, randomised non-inferiority (NCT01443104).Randomisation stratified according presence or absence STEMI.The...
Abstract Background Minimal lipoprotein(a) [Lp(a)] target values are advocated for high‐risk cardiovascular patients. We investigated the prognostic value of Lp(a) in acute setting patients with coronary syndromes (ACS). Materials and methods Plasma levels were collected at time angiography from 1711 hospitalized ACS a multicentre Swiss prospective cohort. Associations between elevated ≥30 mg/dL (cut‐off corresponding to 75th percentile assay) or tertiles baseline, major adverse events...
Abstract Aims We assessed morphological features of near-infrared spectroscopy (NIRS)-detected lipid-rich plaques (LRPs) by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS). Methods results IVUS-NIRS OCT were performed in the two non-infarct-related arteries (non-IRAs) patients undergoing percutaneous coronary intervention for treatment an acute syndrome. A lesion was defined as 4 mm segment with maximum amount lipid core burden index (maxLCBI4mm) each LRP...
Abstract Aims Outcomes after acute coronary syndromes (ACS) are determined by baseline risk profiles, including initial systolic blood pressure (sBP) levels. Herein, we aimed to characterize ACS patients stratified sBP levels and study their relation inflammation, myocardial injury post-ACS outcomes. Methods results We analysed 4724 prospectively recruited according invasively assessed (<100, 100–139, ≥140 mmHg) at admission. Biomarkers of systemic inflammation [high-sensitivity...
Controversy remains regarding the prevalence of hyperglycaemia in non-diabetic patients hospitalised with acute coronary syndrome and its prognostic value for long-term outcomes.We evaluated (defined as fasting glycaemia ⩾10 mmol/l) among no known diabetes at time enrolment prospective Special Program University Medicine-Acute Coronary Syndromes cohort, well impact on all-cause death, myocardial infarction, stroke incidence one year. Among 3858 enrolled between December 2009-December 2014,...
Background The choice of optimal drug-eluting stent therapy for patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention remains uncertain. We aimed to assess the long-term clinical outcomes after biodegradable polymer sirolimus-eluting stents (BP-SES) versus durable everolimus-eluting (DP-EES) in DM. Methods and Results In a prespecified subgroup analysis BIOSCIENCE (Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Stent Versus Durable Everolimus-Eluting...
Different cut-off values of serum lipoprotein (a) [Lp (a)] were recently identified to better stratify cardiovascular risk categories. Both pathophysiological and prognostic Lp remain unclear.Here, the value its correlation with intraplaque features assessed in patients severe carotid artery stenosis undergoing endarterectomy (n = 180). The 10 mg/dL for was selected predict 24-month follow-up acute coronary syndrome (ACS). In addition, association between lipids, collagen, inflammatory...
Accurate markers of atrial fibrillation (AF) recurrences after electrical cardioversion (ECV) are lacking. This study was conducted to assess the value P-wave signal averaging (SAPW) for predicting AF in a nonselected patients population submitted ECV.A total 133 (107 males, 26 females, mean age 66 ± 9 years) were included successful ECV persistent (mean duration 3.6 2.2 months). The ejection fraction (EF) 60 9%, and left (LA) diameter 44 6 mm. SAPW ECG obtained immediately prospectively...
We sought to assess the performance of drug-eluting stents combining an ultrathin cobalt-chromium platform with a biodegradable polymer across categories increasing SYNTAX score (SS).Patients included in BIOSCIENCE trial and randomly allocated treatment sirolimus-eluting (BP-SES) or durable everolimus-eluting (DP-EES) were categorised according SS tertiles (low <8, medium 8-15, high >15). The primary endpoint, target lesion failure (TLF), was defined as composite cardiac death, vessel...
Length of hospital stay (LHS) is an indicator clinical effectiveness. Early discharge (≤72 hours) recommended in patients with acute coronary syndromes (ACS) at low risk complications, but reasons for prolonged LHS poorly reported.We collected data ACS hospitalized the Geneva University Hospitals from 1st July 2013 to 30th June 2015 and used Zwolle index score identify (≤ 3 points). We assessed proportion eligible who were successfully discharged within 72 hours LHS. Outcomes defined as...
Churg-Strauss syndrome (CSS) is a rare multisystemic disorder of unknown origin and cardiac involvement one the most serious manifestations disease, accounting for approximately one-half deaths attributable to CSS. Cardiac manifestation can be acute mimic coronary (ACS). In this setting checking blood leucocyte count reveal hypereosinophilia lead diagnosis
Background There are no uniform workup and follow-up (FU) protocols for patients presenting with cryptogenic embolism (CE) who undergo percutaneous closure of a patent foramen ovale (PFO). Methods We prospectively performed systematic cardiac neurological FU protocol in all underwent PFO order to assess the incidence subsequent adverse events. All received dual antiplatelet therapy 6 months were systematically included 12-month standardised including: clinical evaluation—transthoracic...
Churg-Strauss syndrome (CSS) is a rare multisystemic disorder of unknown origin and cardiac involvement one the most serious manifestations disease, accounting for approximately one-half deaths attributable to CSS. Cardiac manifestation can be acute mimic coronary (ACS). In this setting checking blood leucocyte count reveal hypereosinophilia lead diagnosis
In 2015, Switzerland had a population of 8.3 million inhabitants. Since the first coronary angioplasty performed by Andreas Grüntzig in Zurich 1977, number percutaneous procedures has steadily increased. The aim this report is to summarise current state catheter-based cardiac interventions adults country and detail trends between 2010 2015. 1987, Working Group for Interventional Cardiology Swiss Society collected annually aggregate data from all facilities with catheterisation laboratories...
Extracorporeal life support (ECLS) is increasingly used worldwide in patients with life-threatening hemodynamic or respiratory conditions. The femoral venoarterial cannulation, whether percutaneous surgical, the simplest and quickest method; however, a number of vascular complications may occur. We present two cases which, despite well-placed reperfusion cannula superior artery, apparent limb ischemia cannulated developed rapidly after ECLS implantation was suspected to be caused by arterial...